Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.8603 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0038 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2654 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.2654 | 0.2654 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0679 | 0.0679 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0679 | 0.0679 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0038 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0038 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0679 | 0.0789 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2654 | 0.2654 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.2654 | 0.2654 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0679 | 0.0679 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0679 | 0.0679 |
Onchocerca volvulus | 0.0149 | 0.8603 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0149 | 0.8603 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.2654 | 0.2654 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0679 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2654 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.2654 | 0.3084 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0038 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2654 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2654 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0679 | 0.0789 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 2 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 10 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 24 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.