Detailed information for compound 2191963

Basic information

Technical information
  • TDR Targets ID: 2191963
  • Name: 2-[(E)-2-(2-hydroxyphenyl)ethenyl]phenol
  • MW: 212.084 | Formula: C14H12O2
  • H donors: 2 H acceptors: 2 LogP: 3.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 0
  • SMILES: Oc1ccccc1/C=C/c1ccccc1O
  • InChi: InChI=1S/C14H12O2/c15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)16/h1-10,15-16H/b10-9+
  • InChiKey: YINYVRLKOAKPLN-MDZDMXLPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(E)-2-(2-hydroxyphenyl)vinyl]phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0527 0.4169 0.4169
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1214 0.9828 0.9828
Mycobacterium leprae probable isochorismate synthase EntC 0.0021 0 0.5
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1214 0.9828 0.9828
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0021 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0729 0.5831 1
Schistosoma mansoni 6-phosphofructokinase 0.1235 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1235 1 1
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0021 0 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0021 0 0.5
Brugia malayi UBASH3A protein homolog 0.0021 0 0.5
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0021 0 0.5
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0021 0 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0021 0 0.5
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0527 0.4169 0.4169
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1235 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0196 0.1444 0.1444
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0021 0 0.5
Onchocerca volvulus 0.1235 1 1
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1235 1 1
Mycobacterium leprae conserved hypothetical protein 0.0021 0 0.5
Brugia malayi phosphoglycerate mutase family protein 0.0021 0 0.5
Plasmodium falciparum phosphoglucomutase-2 0.0021 0 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0729 0.5831 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0021 0 0.5
Mycobacterium leprae conserved hypothetical protein 0.0021 0 0.5
Giardia lamblia Hypothetical protein 0.0729 0.5831 0.5
Echinococcus multilocularis ankyrin repeat protein 0.0192 0.141 0.141
Toxoplasma gondii phosphoglycerate mutase family protein 0.0021 0 0.5
Toxoplasma gondii phosphoglycerate mutase 0.0021 0 0.5
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0021 0 0.5
Brugia malayi phosphoglycerate mutase family protein 0.0021 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1235 1 1
Mycobacterium leprae Possible phosphoglycerate mutase 0.0021 0 0.5
Plasmodium vivax phosphoglycerate mutase, putative 0.0021 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0527 0.4169 0.4169
Treponema pallidum phosphoglyceromutase 0.0021 0 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0192 0.141 0.141
Giardia lamblia Hypothetical protein 0.0729 0.5831 0.5
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0021 0 0.5
Plasmodium falciparum phosphoglycerate mutase, putative 0.0021 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0 0.5
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0729 0.5831 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0021 0 0.5
Plasmodium vivax phosphoglucomutase-2, putative 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1235 1 1
Mycobacterium tuberculosis Conserved protein 0.0021 0 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0708 0.566 0.566
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0 0.5
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0021 0 0.5
Toxoplasma gondii phosphoglycerate mutase family protein 0.0021 0 0.5
Mycobacterium leprae conserved hypothetical protein 0.0021 0 0.5
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0021 0 0.5
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1235 1 1
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0021 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0527 0.4169 0.4169
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0021 0 0.5
Mycobacterium tuberculosis Conserved protein 0.0021 0 0.5
Echinococcus granulosus ankyrin repeat protein 0.0192 0.141 0.141
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1214 0.9828 0.9828
Echinococcus granulosus transient receptor potential cation channel 0.0196 0.1442 0.1442
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1214 0.9828 0.9828
Toxoplasma gondii phosphoglycerate mutase family protein 0.0021 0 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0021 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1214 0.9828 0.9828

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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