TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.158 | Formula: C14H29Cl3N8
H donors: 4 H acceptors: 3 LogP: 1.52 Rotable bonds: 11
Rule of 5 violations (Lipinski): 0
SMILES: NCCCNCCCNCCCn1cnc2c1ncnc2N.Cl.Cl.Cl
InChi: InChI=1S/C14H26N8.3ClH/c15-4-1-5-17-6-2-7-18-8-3-9-22-11-21-12-13(16)19-10-20-14(12)22;;;/h10-11,17-18H,1-9,15H2,(H2,16,19,20);3*1H
InChiKey: SFZAKKIFIBTFLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Giardia lamblia	Reductase, putative	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0004	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0004	0.5	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0004	0.5	0.5
Echinococcus multilocularis	oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0004	0.5	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0004	0.5	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0004	0.5	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0004	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0004	0.5	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0004	0.5	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0004	0.5	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus granulosus	steroid dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0004	0.5	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Giardia lamblia	Hypothetical protein	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase	0.0004	0.5	0.5
Brugia malayi	hypothetical protein	0.0004	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0004	0.5	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0004	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.5	0.5
Leishmania major	dehydrogenase-like protein	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0004	0.5	0.5
Echinococcus granulosus	oxidoreductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0004	0.5	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.5	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.5	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0004	0.5	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.5	0.5
Leishmania major	pteridine reductase 1	0.0004	0.5	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.5	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0004	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0004	0.5	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.5	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	oxidoreductase-like protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 13	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0004	0.5	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0004	0.5	0.5
Brugia malayi	hypothetical protein	0.0004	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0004	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3754416

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2194267