Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0222 | 0.0401 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0065 | 0.1166 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0222 | 0.0401 |
Toxoplasma gondii | AMP deaminase | 0.0065 | 0.1166 | 0.2107 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3361 | 0.6071 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0065 | 0.1166 | 0.1778 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0663 | 0.1198 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.02 | 0.5535 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.02 | 0.5535 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0065 | 0.1166 | 0.1778 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.2148 | 0.3881 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.02 | 0.5535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0658 | 0.1188 |
Echinococcus granulosus | adenosine deaminase | 0.02 | 0.5535 | 0.5535 |
Schistosoma mansoni | adenosine deaminase-related | 0.02 | 0.5535 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0663 | 0.1198 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0663 | 0.0663 |
Plasmodium falciparum | AMP deaminase, putative | 0.0065 | 0.1166 | 0.2107 |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Onchocerca volvulus | 0.0162 | 0.432 | 0.7805 | |
Loa Loa (eye worm) | AMP deaminase | 0.0065 | 0.1166 | 0.2107 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0199 | 0.0359 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.3361 | 0.6071 |
Schistosoma mansoni | adenosine deaminase | 0.02 | 0.5535 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.02 | 0.5535 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.2148 | 0.2148 |
Mycobacterium ulcerans | adenosine deaminase | 0.02 | 0.5535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3425 | 0.6187 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0162 | 0.432 | 0.432 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0162 | 0.432 | 0.7805 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0663 | 0.1198 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.02 | 0.5535 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3425 | 0.6187 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0222 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1166 | 0.2107 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0199 | 0.0359 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0065 | 0.1166 | 1 |
Onchocerca volvulus | 0.0036 | 0.0222 | 0.0401 | |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0222 | 0.0401 |
Plasmodium falciparum | adenosine deaminase | 0.02 | 0.5535 | 1 |
Treponema pallidum | adenosine deaminase | 0.02 | 0.5535 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0065 | 0.1166 | 0.1778 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.6506 | 1 |
Leishmania major | AMP deaminase, putative | 0.0065 | 0.1166 | 0.1778 |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.02 | 0.5535 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.037 | 0.037 |
Echinococcus granulosus | AMP deaminase 2 | 0.0065 | 0.1166 | 0.1166 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0663 | 0.1198 |
Onchocerca volvulus | 0.0036 | 0.0222 | 0.0401 | |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0162 | 0.432 | 0.7805 |
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0162 | 0.432 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.432 | 0.7805 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.02 | 0.5535 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0222 | 0.0401 |
Echinococcus multilocularis | adenosine deaminase | 0.02 | 0.5535 | 0.5535 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.02 | 0.5535 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0658 | 0.1188 |
Echinococcus multilocularis | tumor protein p63 | 0.0337 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0065 | 0.1166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3361 | 0.6071 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0065 | 0.1166 | 0.2107 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.02 | 0.5535 | 0.8455 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0065 | 0.1166 | 0.1166 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.2148 | 0.2148 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0199 | 0.0199 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.3361 | 0.6071 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0222 | 0.0401 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0199 | 0.0359 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.037 | 0.037 |
Leishmania major | hypothetical protein, conserved | 0.0065 | 0.1166 | 0.1778 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3425 | 0.6187 |
Brugia malayi | hypothetical protein | 0.0133 | 0.3361 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0222 | 0.0401 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0663 | 0.1198 |
Leishmania major | adenine aminohydrolase | 0.02 | 0.5535 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0222 | 0.0222 |
Brugia malayi | adenosine monophosphate deaminase | 0.0065 | 0.1166 | 0.2107 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.1005 | 0.1816 |
Schistosoma mansoni | AMP deaminase | 0.0065 | 0.1166 | 0.2107 |
Brugia malayi | Pip kinase protein 2 | 0.0162 | 0.432 | 0.7805 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.5535 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0199 | 0.0359 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0065 | 0.1166 | 0.2107 | |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3425 | 0.6187 |
Onchocerca volvulus | 0.0036 | 0.0222 | 0.0401 | |
Trichomonas vaginalis | adenosine deaminase, putative | 0.02 | 0.5535 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.02 | 0.5535 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0065 | 0.1166 | 0.2107 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0065 | 0.1166 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0222 | 0.0401 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0222 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0675 | 0.1219 |
Onchocerca volvulus | 0.0049 | 0.0658 | 0.1188 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.1513 | 0.2733 |
Loa Loa (eye worm) | pip kinase 2 | 0.0162 | 0.432 | 0.7805 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1166 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0222 | 0.0401 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0222 | 0.0401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.3 mM | Ability to inhibit E. coli adenylate kinase II, activity expressed as Inhibition constant | ChEMBL. | 6279845 |
Vmax (ADMET) | = 0 % | Ability to inhibit E. coli adenylate kinase II, activity expressed as Maximum velocity | ChEMBL. | 6279845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.