TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.463 | Formula: C20H30N2O5
H donors: 3 H acceptors: 4 LogP: 3.82 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC(C(=O)N[C@@H](C(=O)O)CC(C)C)NC(=O)OCc1ccccc1)C
InChi: 1S/C20H30N2O5/c1-13(2)10-16(18(23)21-17(19(24)25)11-14(3)4)22-20(26)27-12-15-8-6-5-7-9-15/h5-9,13-14,16-17H,10-12H2,1-4H3,(H,21,23)(H,22,26)(H,24,25)/t16?,17-/m1/s1
InChiKey: XGJGWYRHLPSMLW-ZYMOGRSISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cysteine protease	0.0363	1	1
Giardia lamblia	Hypothetical protein	0.0067	0.1436	0.5
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Loa Loa (eye worm)	hypothetical protein	0.0243	0.6528	0.6528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Brugia malayi	Cathepsin L-like precursor	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Loa Loa (eye worm)	cathepsin B	0.0067	0.1436	0.1436
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0363	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0067	0.1436	0.1326
Plasmodium vivax	vivapain-2	0.0363	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0187	0.4908	0.4908
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1402	0.1213
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Echinococcus multilocularis	calpain A	0.0073	0.1612	0.1427
Trypanosoma cruzi	cysteine protease, putative	0.0187	0.4908	0.4908
Echinococcus multilocularis	cathepsin L cysteine protease	0.0363	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0067	0.1436	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.012	0.2969	0.2969
Plasmodium vivax	serine-repeat antigen (SERA)	0.0067	0.1436	0.1326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0073	0.1604	0.1418
Brugia malayi	Papain family cysteine protease containing protein	0.0187	0.4908	0.4908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Schistosoma mansoni	cathepsin F (C01 family)	0.0243	0.6528	0.6451
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0067	0.1436	0.1246
Echinococcus granulosus	cathepsin l1	0.0363	1	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0121	0.3013	0.2859
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Brugia malayi	cathepsin L-like precursor	0.0243	0.6528	0.6528
Schistosoma mansoni	cathepsin C	0.0067	0.1436	0.1246
Trypanosoma cruzi	major cysteine proteinase, putative	0.0067	0.1436	0.1436
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Leishmania major	cysteine peptidase A (CPA)	0.0363	1	1
Brugia malayi	Cathepsin L-like precursor	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Schistosoma mansoni	protein kinase	0.0121	0.3013	0.2859
Loa Loa (eye worm)	cysteine protease	0.0363	1	1
Brugia malayi	calpain family protein 1	0.0066	0.1402	0.1402
Plasmodium vivax	unspecified product	0.012	0.2969	0.2879
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0187	0.4908	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0067	0.1436	0.1246
Giardia lamblia	Cathepsin L-like protease	0.0067	0.1436	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.6528	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Plasmodium vivax	vivapain-3	0.0187	0.4908	0.4842
Schistosoma mansoni	copper/topaquinone oxidase	0.0087	0.2014	0.1837
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0067	0.1436	0.1436
Giardia lamblia	Cysteine protease	0.0067	0.1436	0.5
Echinococcus multilocularis	cysteine protease	0.0363	1	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0107	0.2585	0.2585
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0067	0.1436	0.5
Plasmodium vivax	vivapain-2	0.0363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Echinococcus multilocularis	cathepsin b	0.0067	0.1436	0.1246
Plasmodium vivax	unspecified product	0.0187	0.4908	0.4842
Toxoplasma gondii	cathepsin CPL	0.0363	1	1
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0363	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0067	0.1436	0.1246
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.012	0.2969	0.2969
Onchocerca volvulus	Cathepsin L homolog	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0067	0.1436	0.1326
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Trypanosoma brucei	antigen, putative	0.0025	0.0216	0.0216
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0067	0.1436	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0067	0.1436	0.1436
Toxoplasma gondii	cathepsin CPC1	0.0067	0.1436	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Giardia lamblia	Cysteine protease	0.0067	0.1436	0.5
Echinococcus granulosus	cathepsin L cysteine protease	0.0187	0.4908	0.4795
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0073	0.1604	0.1418
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0363	1	1
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Echinococcus granulosus	calpain A	0.0073	0.1612	0.1427
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Onchocerca volvulus		0.0363	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Echinococcus multilocularis	cathepsin L	0.0187	0.4908	0.4795
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0363	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0216	0.0216
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0067	0.1436	0.1326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0067	0.1436	0.1246
Giardia lamblia	Cysteine protease	0.0067	0.1436	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0067	0.1436	0.1436
Trypanosoma cruzi	cysteine proteinase, putative	0.0187	0.4908	0.4908
Loa Loa (eye worm)	calpain	0.0025	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1186	0.1186
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.4908	0.4908
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.4908	0.4908
Echinococcus granulosus	cathepsin L	0.0067	0.1436	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0684	0.0684
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Echinococcus granulosus	cysteine protease	0.0187	0.4908	0.4795
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0363	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0067	0.1436	0.1436
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Trypanosoma cruzi	cysteine peptidase, putative	0.0363	1	1
Echinococcus granulosus	cathepsin b	0.0067	0.1436	0.1246
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0067	0.1436	0.1326
Brugia malayi	Cathepsin L-like precursor	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2969	0.2969
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0363	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.1436	0.1436
Brugia malayi	cathepsin F-like cysteine proteinase	0.012	0.2969	0.2969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0363	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0363	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Brugia malayi	cathepsin L precursor	0.0067	0.1436	0.1436
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0187	0.4908	0.4795
Brugia malayi	cathepsin L-like cysteine proteinase	0.0067	0.1436	0.1436
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0067	0.1436	0.1436
Onchocerca volvulus		0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Echinococcus multilocularis	cathepsin b	0.0067	0.1436	0.1246
Leishmania major	cathepsin L-like protease	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.4908	0.4054
Onchocerca volvulus		0.0363	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0243	0.6528	0.6528
Brugia malayi	calpain family protein 1	0.0066	0.1402	0.1402
Giardia lamblia	Cathepsin L-like protease	0.0067	0.1436	0.5
Schistosoma mansoni	cathepsin s	0.012	0.2969	0.2814
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0121	0.3013	0.2859
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0363	1	1
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Entamoeba histolytica	hypothetical protein	0.0067	0.1436	0.1436
Onchocerca volvulus	Cathepsin L homolog	0.0067	0.1436	0.0807
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Loa Loa (eye worm)	ctsf protein	0.0363	1	1
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Plasmodium vivax	serine-repeat antigen (SERA)	0.0067	0.1436	0.1326
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Loa Loa (eye worm)	fibroinase	0.0363	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0363	1	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.4908	0.4054
Toxoplasma gondii	cathepsin CPC2	0.0067	0.1436	0.0723
Brugia malayi	cathepsin F-like cysteine proteinase	0.0067	0.1436	0.1436
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0107	0.2585	0.2585
Loa Loa (eye worm)	calpain family protein 1	0.0066	0.1402	0.1402
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0243	0.6528	0.6528
Schistosoma mansoni	hypothetical protein	0.0087	0.2014	0.1837
Onchocerca volvulus	Cathepsin L homolog	0.0363	1	1
Brugia malayi	fibroinase precursor	0.0067	0.1436	0.1436
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0073	0.1604	0.1418
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.6528	0.6528
Echinococcus multilocularis	cathepsin L cysteine protease	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Echinococcus granulosus	cathepsin b	0.0067	0.1436	0.1246
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Echinococcus granulosus	cathepsin l1	0.0243	0.6528	0.6451
Schistosoma mansoni	protein kinase	0.0121	0.3013	0.2859
Trypanosoma cruzi	cysteine peptidase, putative	0.012	0.2969	0.2969
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0067	0.1436	0.1436
Brugia malayi	calpain 7	0.0025	0.0216	0.0216
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0067	0.1436	0.1326
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0048	0.09	0.09
Giardia lamblia	Hypothetical protein	0.0067	0.1436	0.5
Brugia malayi	cathepsin B-like cysteine proteinase	0.0067	0.1436	0.1436
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Brugia malayi	Cathepsin L-like precursor	0.0243	0.6528	0.6528
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0067	0.1436	0.1436
Trypanosoma cruzi	cysteine proteinase, putative	0.0187	0.4908	0.4908
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0243	0.6528	0.6528
Echinococcus granulosus	cathepsin L	0.0187	0.4908	0.4795
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0067	0.1436	0.1436
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0067	0.1436	0.1326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.4908	0.4908
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1402	0.1402
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0363	1	1
Onchocerca volvulus		0.0363	1	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0073	0.1604	0.1418
Leishmania major	cathepsin L-like protease	0.0363	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Leishmania major	cathepsin L-like protease	0.0363	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0067	0.1436	0.1436
Onchocerca volvulus	Cathepsin F homolog	0.0363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0187	0.4908	0.4795
Onchocerca volvulus		0.0067	0.1436	0.0807
Toxoplasma gondii	cathepsin B	0.0067	0.1436	0.0723
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Trypanosoma cruzi	cruzipain precursor, putative	0.0363	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0363	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0067	0.1436	0.1326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0363	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0067	0.1436	0.1246
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Loa Loa (eye worm)	hypothetical protein	0.012	0.2969	0.2969
Giardia lamblia	Encystation-specific protease	0.0067	0.1436	0.5
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0067	0.1436	0.1436
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0025	0.0216	0.0216
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.09	0.09
Entamoeba histolytica	cysteine proteinase 2	0.0187	0.4908	0.4908
Brugia malayi	Cathepsin L-like precursor	0.0363	1	1
Brugia malayi	Cathepsin L-like precursor	0.0243	0.6528	0.6528
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.4908	0.4908
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0363	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0216	0.0216
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Onchocerca volvulus		0.0363	1	1
Onchocerca volvulus		0.0363	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0067	0.1436	0.1326
Onchocerca volvulus		0.0243	0.6528	0.6273
Echinococcus multilocularis	calpain family protein 1, d	0.0048	0.09	0.0699
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Entamoeba histolytica	protein kinase, putative	0.0018	0.0009	0.0009
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0067	0.1436	0.1326
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0187	0.4908	0.4908
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Plasmodium vivax	unspecified product	0.0067	0.1436	0.1326
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.4908	0.4908
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Leishmania major	cathepsin L-like protease	0.0363	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0067	0.1436	0.1246
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.1436	0.1436
Brugia malayi	Papain family cysteine protease containing protein	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2969	0.2969
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0216	0.0216
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Schistosoma mansoni	cathepsin F (C01 family)	0.0363	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0187	0.4908	0.4795
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.4908	0.4908
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0216	0.0216
Entamoeba histolytica	cysteine protease, putative	0.0067	0.1436	0.1436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Brugia malayi	Cathepsin L-like precursor	0.0363	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0067	0.1436	0.1436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.6528	0.5946
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0067	0.1436	0.1326
Schistosoma mansoni	protein kinase	0.0121	0.3013	0.2859
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0216	0.0216
Leishmania major	cathepsin L-like protease	0.0363	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1436	0.1246
Leishmania major	cathepsin L-like protease	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0067	0.1436	0.1246
Echinococcus multilocularis	amiloride sensitive amine oxidase	0.0087	0.2014	0.1837
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Giardia lamblia	Cathepsin L precursor	0.0067	0.1436	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0067	0.1436	0.1436
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.1436	0.1436
Entamoeba histolytica	cysteine proteinase, putative	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0363	1	1
Brugia malayi	Cathepsin L-like precursor	0.012	0.2969	0.2969
Echinococcus multilocularis	cathepsin L	0.0067	0.1436	0.1246
Trypanosoma cruzi	cysteine peptidase, putative	0.0363	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0363	1	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0067	0.1436	0.1436
Plasmodium vivax	calpain, putative	0.0025	0.0216	0.009
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1436	0.1436
Giardia lamblia	Cathepsin B precursor	0.0067	0.1436	0.5
Leishmania major	cathepsin L-like protease	0.0363	1	1
Plasmodium vivax	vivapain-1	0.0187	0.4908	0.4842
Entamoeba histolytica	cysteine protease, putative	0.0187	0.4908	0.4908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0363	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0067	0.1436	0.5
Echinococcus granulosus	amiloride sensitive amine oxidase	0.0087	0.2014	0.1837
Giardia lamblia	Cysteine protease	0.0067	0.1436	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0363	1	1
Leishmania major	cathepsin L-like protease	0.0363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.6528	0.6528
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0216	0.0216
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0067	0.1436	0.0723
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.012	0.2969	0.2969
Onchocerca volvulus		0.0363	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.007 uM	inhibitory activity measured against recombinant human Calpain-I receptor	ChEMBL.	9748367
IC50 (binding)	= 0.007 uM	inhibitory activity measured against recombinant human Calpain-I receptor	ChEMBL.	9748367

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 219675