Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase | 614 aa | 507 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0138 | 0.0434 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.027 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.027 | 0.0519 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.027 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.027 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0251 | 0.5213 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3181 | 0.3181 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Echinococcus granulosus | geminin | 0.0185 | 0.367 | 0.367 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.027 | 0.0519 |
Brugia malayi | beta-lactamase | 0.0039 | 0.027 | 0.085 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.027 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.027 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.027 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.027 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.027 | 0.027 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3181 | 0.3181 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.027 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.027 | 0.027 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.027 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0455 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.027 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3181 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.027 | 0.085 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.027 | 0.0519 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0501 | 0.1575 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0501 | 0.1575 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.027 | 0.0519 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0138 | 0.0376 |
Echinococcus multilocularis | geminin | 0.0185 | 0.367 | 0.367 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3181 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3181 | 0.3181 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0455 | 1 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.027 | 0.0519 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3181 | 0.3181 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.367 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.027 | 0.085 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.027 | 0.0519 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.027 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.027 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.027 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.027 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3181 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.027 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.027 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3181 | 0.8667 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.027 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.367 | 1 |
Onchocerca volvulus | 0.0039 | 0.027 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3181 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.027 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0501 | 0.1575 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.027 | 0.0519 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.027 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.027 | 0.085 |
Onchocerca volvulus | 0.0039 | 0.027 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.027 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0501 | 0.1575 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.027 | 0.0519 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3181 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3181 | 0.3181 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.027 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.027 | 1 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.027 | 0.0519 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.027 | 0.0737 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.027 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0455 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3181 | 0.3181 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0138 | 0.0434 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.027 | 0.0737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.716 | Inhibition against Acetylcholinesterase (AChE) | ChEMBL. | 8558505 |
IC50 (binding) | = 52 nM | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | ChEMBL. | 1469686 |
IC50 (binding) | = 52 nM | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | ChEMBL. | 1469686 |
IC50 (binding) | = 52 nM | Inhibition of AChE | ChEMBL. | 20053484 |
Log IC50 (binding) | = 1.716 | Inhibition against Acetylcholinesterase (AChE) | ChEMBL. | 8558505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.