Animals (functional)
|
= 0 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 0 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 12 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 12 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 25 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 25 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 38 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 38 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 43 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 43 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 23 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 50 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 50 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 57 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 57 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 30 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 1 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 62 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 0.25 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 71 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 71 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 44 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 86 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
Animals (functional)
|
= 86 %
|
Incidence of disease (mouse type II collagen) was scored as the percentage of animals within each experimental group that exhibited joint or limb inflammation on day 37 at intraperitoneal dose of 0.50 mg/kg (deaths observed at 1.5 mg/kg)
|
ChEMBL.
|
9022805
|
IC50 (functional)
|
= 1.9 nM
|
Concentration required to inhibit the growth of L1210 cells.
|
ChEMBL.
|
9022805
|
IC50 (functional)
|
= 1.9 nM
|
Concentration required to inhibit the growth of L1210 cells.
|
ChEMBL.
|
9022805
|
IC50 (functional)
|
= 126 nM
|
Concentration required to inhibit the growth of chang liver cells.
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.19 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.19 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.19 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.19 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.22 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.22 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.25 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.25 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.29 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.29 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.31 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.31 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 23 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.32 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.32 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 1 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.33 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.33 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.34 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.34 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 0.25 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.38 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.38 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 30 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.42 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.42 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 37 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.43 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|
Paw swelling (functional)
|
= 2.43 mM
|
Tested for antiinflammatory activity on mouse type II collagen arthritis as Paw swelling of all animals in each group on day 44 at intraperitoneal dose of 0.50 mg/kg
|
ChEMBL.
|
9022805
|