Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0086 | 0.2783 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0086 | 0.2783 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0086 | 0.2783 | 0.2589 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.2783 | 0.2589 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0086 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0046 | 0.0262 | 0.0262 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0086 | 0.2783 | 0.2783 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0086 | 0.2783 | 0.2589 |
Onchocerca volvulus | 0.0086 | 0.2783 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0086 | 0.2783 | 0.2783 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0086 | 0.2783 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.2783 | 0.2783 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0086 | 0.2783 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0262 | 0.0262 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.2783 | 0.2589 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.2783 | 0.2589 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | nuclear hormone receptor | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | steroid hormone receptor | 0.0086 | 0.2783 | 0.2783 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0086 | 0.2783 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0203 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.2783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | ecdysteroid receptor | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | nuclear receptor NHR-88 | 0.0086 | 0.2783 | 0.2783 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.2783 | 0.2589 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.2783 | 0.2783 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0086 | 0.2783 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0086 | 0.2783 | 0.2783 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0086 | 0.2783 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0046 | 0.0262 | 0.0262 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0262 | 0.0262 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.2783 | 0.2589 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0086 | 0.2783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0086 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0086 | 0.2783 | 0.2589 |
Echinococcus granulosus | FTZ F1 alpha | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0086 | 0.2783 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0086 | 0.2783 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0086 | 0.2783 | 0.2783 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0046 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0086 | 0.2783 | 0.2589 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0086 | 0.2783 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2783 | 0.2589 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0086 | 0.2783 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.2783 | 0.2783 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0086 | 0.2783 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.2783 | 0.2589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0046 | 0.0262 | 0.0941 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0086 | 0.2783 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.2783 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0086 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0086 | 0.2783 | 0.2589 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.2783 | 0.2783 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.2783 | 0.2589 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0046 | 0.0262 | 0.0941 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | 0 % | In vitro efficacy tested on human D4.4 receptor were coexpressed with GRqo5 in HEK293 cells using FLIPR assay (Efficacy relative to 10 microM dopamine) | ChEMBL. | 15239663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.