Detailed information for compound 219838

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.345 | Formula: C15H21N3O4
  • H donors: 2 H acceptors: 4 LogP: 0 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/N=C/N1CC[C@H](C1)C1=C(C(=O)O)N2[C@H](C1)[C@H](C2=O)[C@H](O)C
  • InChi: 1S/C15H21N3O4/c1-8(19)12-11-5-10(9-3-4-17(6-9)7-16-2)13(15(21)22)18(11)14(12)20/h7-9,11-12,19H,3-6H2,1-2H3,(H,21,22)/b16-7+/t8-,9-,11-,12-/m1/s1
  • InChiKey: XNYYVUZDUJBMMK-SWOAKXMWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0002 0.0002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0001 0.0001
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0002 0.0002
Leishmania major oxidoreductase-like protein 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.4135 0.2442 0.2441
Echinococcus granulosus p2X purinoceptor 4 0.0197 0.011 0.011
Mycobacterium ulcerans endonuclease IV 0.0075 0.0038 0.0037
Loa Loa (eye worm) Smad1 0.0016 0.0003 0.0003
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 1.2412 0.7344 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0013
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.4135 0.2442 0.2442
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.0138
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0028 0.0028
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0003 0.0003
Schistosoma mansoni chromobox protein 0.0068 0.0034 0.0034
Chlamydia trachomatis dihydrofolate reductase 1.6898 1 1
Schistosoma mansoni netrin receptor unc5 0.0014 0.0002 0.0002
Entamoeba histolytica NAD synthetase, putative 0.008 0.0041 1
Onchocerca volvulus 0.0069 0.0034 0.0141
Brugia malayi Protein kinase domain containing protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) thymidylate synthase 0.4135 0.2442 0.2442
Echinococcus multilocularis p2X purinoceptor 4 0.0197 0.011 0.011
Mycobacterium ulcerans NAD synthetase 0.008 0.0041 0.004
Schistosoma mansoni smad 0.0016 0.0003 0.0003
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0032 0.0012 0.0017
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0003
Echinococcus granulosus chromobox protein 1 0.0068 0.0034 0.0034
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0048 0.0022 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0032 0.0012 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0002 0.0002
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0028 0.0028
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0016 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0165 0.0091 0.0091
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.008 0.0041 0.0056
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0006 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0014 0.0014
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0036 0.0036
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 1.2412 0.7344 1
Echinococcus multilocularis p2X purinoceptor 4 0.0197 0.011 0.011
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000019175 0.0000000019175
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0002 0.0002
Echinococcus multilocularis Ankyrin 0.0014 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0028 0.0028
Toxoplasma gondii endonuclease IV APN 0.0075 0.0038 0.0051
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.008 0.0041 0.0039
Schistosoma mansoni P2X receptor subunit 0.0197 0.011 0.011
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0014 0.0002 0.0002
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0032 0.0012 0.0016
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0028
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.6898 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0009 0.0009
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0032 0.0012 0.0016
Entamoeba histolytica hypothetical protein 0.0035 0.0014 0.3423
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000019175 0.0000000019175
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.008 0.0041 0.0353
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Mycobacterium ulcerans thymidylate synthase 0.4135 0.2442 0.2442
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.6898 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 1.2412 0.7344 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0003 0.0003
Echinococcus granulosus p2X purinoceptor 4 0.0197 0.011 0.011
Echinococcus granulosus intermediate filament protein 0.0026 0.0009 0.0009
Echinococcus granulosus smad 0.0016 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0026 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0038 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0028 0.0038
Trypanosoma cruzi NAD+ synthase, putative 0.008 0.0041 0.0055
Brugia malayi thymidylate synthase 0.4135 0.2442 0.2442
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0006 0.0006
Echinococcus granulosus p2X purinoceptor 4 0.0197 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Echinococcus multilocularis chromobox protein 1 0.0068 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.008 0.0041 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0009 0.0081
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0002 0.0001
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0028 0.0037
Mycobacterium tuberculosis Hypothetical protein 0.1967 0.1158 0.1157
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0404 0.0233 0.0233
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0003
Brugia malayi intermediate filament protein 0.0026 0.0009 0.0009
Brugia malayi hypothetical protein 0.0011 0.0000070632 0.0000070632
Brugia malayi Cytochrome P450 family protein 0.0012 0.0001 0.0001
Brugia malayi SET domain containing protein 0.0013 0.0001 0.0001
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0002 0.0007
Onchocerca volvulus 0.0026 0.0009 0.0036
Schistosoma mansoni P2X receptor subunit 0.0197 0.011 0.011
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0231 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.0138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0022 0.0022
Leishmania major pteridine reductase 1 0.0196 0.0109 0.0148
Trypanosoma brucei oxidoreductase-like protein 0.0014 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0018 0.0153
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0028 0.0028
Echinococcus granulosus death domain containing protein 0.0014 0.0002 0.0002
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0038 0.0051
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0034 0.0034
Echinococcus multilocularis GPCR, family 2 0.0015 0.0002 0.0002
Giardia lamblia NH3-dependent NAD+ synthetase 0.008 0.0041 0.5
Schistosoma mansoni GMP synthetase 0.0032 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0033 0.0013 0.0013
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0014 0.0002 0.0003
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0011
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0001 0.0001
Echinococcus multilocularis p2X purinoceptor 4 0.0197 0.011 0.011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0018 0.0072
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0165 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Brugia malayi hypothetical protein 0.1967 0.1158 0.1158
Echinococcus multilocularis musashi 0.0026 0.0009 0.0009
Echinococcus multilocularis smad 0.0016 0.0003 0.0003
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0038 0.0036
Schistosoma mansoni dihydrofolate reductase 1.6898 1 1
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.008 0.0041 0.0041
Echinococcus granulosus GPCR family 2 0.0015 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0009 0.0009
Echinococcus granulosus chromobox protein 1 0.0068 0.0034 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0002 0.0001
Trypanosoma brucei pteridine reductase 1 0.019 0.0106 0.0143
Onchocerca volvulus 0.003 0.0011 0.0045
Echinococcus granulosus lamin dm0 0.0026 0.0009 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0002 0.0002
Echinococcus granulosus thymidylate synthase 0.4135 0.2442 0.2442
Brugia malayi Dihydrofolate reductase 1.6898 1 1
Treponema pallidum NAD synthetase 0.008 0.0041 0.5
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0029 0.0029
Echinococcus multilocularis lamin 0.0026 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0002 0.0002
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 1.2412 0.7344 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0028 0.0028
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0004 0.0006
Brugia malayi GMP synthase 0.0032 0.0012 0.0012
Mycobacterium ulcerans GMP synthase 0.0032 0.0012 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0002 0.0002
Trypanosoma cruzi NAD+ synthase, putative 0.008 0.0041 0.0055
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0006 0.0006
Echinococcus granulosus lamin 0.0026 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0032 0.0012 0.0017
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0036 0.0036
Mycobacterium ulcerans epimerase 0.002 0.0005 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0003 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0028 0.0028
Brugia malayi Heterochromatin protein 1 0.0068 0.0034 0.0034
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0028 0.0028
Brugia malayi MH2 domain containing protein 0.0234 0.0132 0.0132
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0002 0.0002
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0032 0.0012 0.0012
Schistosoma mansoni P2X receptor subunit 0.0197 0.011 0.011
Brugia malayi Uncoordinated protein 44 0.0014 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0002 0.0002
Echinococcus granulosus dihydrofolate reductase 1.6898 1 1
Echinococcus granulosus Ankyrin 0.0014 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0034 0.0291
Plasmodium vivax SET domain protein, putative 0.0058 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni P2X receptor subunit 0.0197 0.011 0.011
Trypanosoma brucei NAD+ synthase, putative 0.008 0.0041 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0001 0.0001
Schistosoma mansoni chromobox protein 0.0068 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Echinococcus multilocularis geminin 0.0165 0.0091 0.0091
Brugia malayi hypothetical protein 0.0035 0.0014 0.0014
Onchocerca volvulus 0.046 0.0266 0.1089
Trichomonas vaginalis set domain proteins, putative 0.046 0.0266 0.2295
Entamoeba histolytica hypothetical protein 0.0035 0.0014 0.3423
Loa Loa (eye worm) hypothetical protein 0.0038 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0035 0.0014 0.3423
Echinococcus multilocularis chromobox protein 1 0.0068 0.0034 0.0034
Leishmania major NAD synthase, putative 0.008 0.0041 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0034 0.0291
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0034 0.0034
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.013 0.013
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0058 0.0028 0.0028
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0002 0.0002
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.008 0.0041 0.0056
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0005 0.0021
Loa Loa (eye worm) RecQ helicase 0.0021 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0035 0.0014 0.3423
Loa Loa (eye worm) dihydrofolate reductase 1.6898 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0006 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0028 0.0028
Onchocerca volvulus 0.0026 0.0009 0.0036
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0005 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0005 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0038 0.0051
Echinococcus multilocularis dihydrofolate reductase 1.6898 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0012
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0003 0.0003
Echinococcus granulosus geminin 0.0165 0.0091 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0003 0.0003
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 1.2412 0.7344 1
Schistosoma mansoni Smad4 0.0016 0.0003 0.0003
Echinococcus multilocularis lamin dm0 0.0026 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0075 0.0038 0.0038
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1967 0.1158 0.1577
Leishmania major dihydrofolate reductase-thymidylate synthase 1.2412 0.7344 1
Onchocerca volvulus 0.4135 0.2442 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Onchocerca volvulus 0.0014 0.0002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0009 0.0081
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Brugia malayi Cytochrome P450 family protein 0.0012 0.0001 0.0001
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0028 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0022 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0028 0.0026
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0014 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Echinococcus granulosus Smad4 0.0016 0.0003 0.0003
Echinococcus multilocularis thymidylate synthase 0.4135 0.2442 0.2442
Brugia malayi chromobox protein homolog 3 0.0038 0.0016 0.0016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0028 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0014 0.0014
Brugia malayi Pre-SET motif family protein 0.0404 0.0233 0.0233
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.4135 0.2442 0.2438
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0002 0.0002
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0002 0.0002
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.6898 1 1
Echinococcus multilocularis Smad4 0.0016 0.0003 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0018 0.0153
Plasmodium vivax GMP synthetase, putative 0.0032 0.0012 0.0017
Brugia malayi Death domain containing protein 0.0014 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0028 0.0028
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0003 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0014 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0132 0.0132
Mycobacterium ulcerans hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Brugia malayi Smad1 0.0016 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.1967 0.1158 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0001 0.0001
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0000070632 0.0000070632
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.008 0.0041 0.0036
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0038 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0013 0.0013
Echinococcus granulosus bloom syndrome protein 0.0021 0.0006 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0026 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Antibacterial activity (functional) = 0.2 In vitro antibacterial activity against Escherichia coli NIHJ JC-2. ChEMBL. 11814802
Antibacterial activity (functional) < 0.025 In vitro antibacterial activity against Staphylococcus aureus 209P JC-1. ChEMBL. 11814802
Antibacterial activity (functional) = 0.2 In vitro antibacterial activity against Escherichia coli NIHJ JC-2. ChEMBL. 11814802
Antibacterial activity (functional) = 0.39 In vitro antibacterial activity against Ps. auruginosa 26. ChEMBL. 11814802
Antibacterial activity (functional) = 0.78 In vitro antibacterial activity against Proteus vulgaris IAM 1025. ChEMBL. 11814802
Antibacterial activity (functional) = 3.13 In vitro antibacterial activity against Staphylococcus aureus 3004 Methicillin-resistant S. aureus. ChEMBL. 11814802
Recovery (ADMET) = 48 % Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg ChEMBL. 11814802
Recovery (ADMET) = 48 % Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg ChEMBL. 11814802
Stability (functional) = 0.078 Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) ChEMBL. 11814802
Stability (functional) = 0.91 Compound stability against human renal DHP-1 relative to imipenem (IMP) ChEMBL. 11814802
Stability (functional) = 0.078 Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) ChEMBL. 11814802
Stability (functional) = 0.91 Compound stability against human renal DHP-1 relative to imipenem (IMP) ChEMBL. 11814802

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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