Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0724 | 0.3441 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1294 | 0.852 | 0.5 |
Treponema pallidum | flavodoxin | 0.0558 | 0.196 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0339 | 0 | 0.5 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0558 | 0.196 | 0.196 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.146 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.146 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.146 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.146 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.1294 | 0.852 | 0.8159 |
Leishmania major | p450 reductase, putative | 0.146 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.146 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.146 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0724 | 0.3441 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0901 | 0.502 | 0.3828 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1294 | 0.852 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.146 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0735 | 0.354 | 0.0151 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1294 | 0.852 | 0.8159 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0901 | 0.502 | 0.502 |
Brugia malayi | FAD binding domain containing protein | 0.0901 | 0.502 | 0.488 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0558 | 0.196 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0369 | 0.0272 | 0.0272 |
Brugia malayi | FAD binding domain containing protein | 0.146 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.146 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.146 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.146 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.146 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0558 | 0.196 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.146 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0558 | 0.196 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.146 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0558 | 0.196 | 0.1735 |
Loa Loa (eye worm) | hypothetical protein | 0.146 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0558 | 0.196 | 0.5 |
Echinococcus granulosus | methionine synthase reductase | 0.0901 | 0.502 | 0.3828 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0558 | 0.196 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0339 | 0 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.146 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0901 | 0.502 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.146 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.146 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.1294 | 0.852 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.146 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.146 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.146 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0901 | 0.502 | 0.2407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.