Detailed information for compound 219910

Basic information

Technical information
  • TDR Targets ID: 219910
  • Name: (7S,9S)-N,N-dimethyl-9-phenyl-6,7,8,9-tetrahy dro-5H-benzo[7]annulen-7-amine
  • MW: 265.393 | Formula: C19H23N
  • H donors: 0 H acceptors: 0 LogP: 4.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN([C@H]1CCc2c([C@@H](C1)c1ccccc1)cccc2)C
  • InChi: 1S/C19H23N/c1-20(2)17-13-12-16-10-6-7-11-18(16)19(14-17)15-8-4-3-5-9-15/h3-11,17,19H,12-14H2,1-2H3/t17-,19-/m0/s1
  • InChiKey: WUBABGHLEBDGMP-HKUYNNGSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dimethyl-[(7S,9S)-9-phenyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl]amine
  • dimethyl-[(7S,9S)-9-phenyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0315 0.0313 0.0301
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0746 0.0854 0.1255
Schistosoma mansoni amine GPCR 0.0315 0.0313 0.0301
Brugia malayi Serotonin receptor 0.0315 0.0313 0.0301
Brugia malayi G-protein coupled receptor 0.0315 0.0313 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0445 0.0477 0.0477
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.5416 0.6713 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.5416 0.6713 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0315 0.0313 0.0301
Schistosoma mansoni dihydrofolate reductase 0.8036 1 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0315 0.0313 0.0301
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0315 0.0313 0.0301
Brugia malayi ORL1-like opioid receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi GnHR receptor homolog 0.0315 0.0313 0.0301
Echinococcus multilocularis g protein coupled receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0315 0.0313 0.0301
Echinococcus multilocularis glutathione s transferase mu 0.0077 0.0016 0.0003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0315 0.0313 0.0301
Brugia malayi putative neuropeptide receptor NPR1 0.0315 0.0313 0.0301
Schistosoma mansoni amine GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0315 0.0313 0.0313
Echinococcus granulosus neuropeptide s receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0315 0.0313 0.0301
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus glutathione s transferase mu 0.0077 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni GST class-mu 0.0077 0.0016 0.0003
Echinococcus granulosus glutathione S transferase 0.0077 0.0016 0.0003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus neuropeptide receptor A26 0.0315 0.0313 0.0301
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.0477 0.0692
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Entamoeba histolytica cell division protein kinase 2, putative 0.0075 0.0013 0.5
Schistosoma mansoni amine GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0315 0.0313 0.0301
Schistosoma mansoni hypothetical protein 0.0315 0.0313 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni neuropeptide f receptor 76f 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) dihydrofolate reductase 0.8036 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0315 0.0313 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Brugia malayi Melatonin receptor type 1A 0.0315 0.0313 0.0301
Brugia malayi putative neuropeptide receptor 0.0315 0.0313 0.0301
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0315 0.0313 0.0301
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.0477 0.0692
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Echinococcus multilocularis sex peptide receptor 0.0315 0.0313 0.0301
Schistosoma mansoni amine GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni biogenic amine receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis dro:myosuppressin receptor 0.0315 0.0313 0.0301
Echinococcus granulosus alpha 1A adrenergic receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0315 0.0313 0.0313
Echinococcus multilocularis orexin receptor type 2 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0402 0.0424 0.0424
Onchocerca volvulus 0.1567 0.1885 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0315 0.0313 0.0301
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.0313 0.0301
Schistosoma mansoni biogenic amine receptor 0.0315 0.0313 0.0301
Echinococcus granulosus prostaglandin H2 D isomerase 0.0077 0.0016 0.0003
Echinococcus multilocularis neuropeptide Y receptor 0.0315 0.0313 0.0301
Brugia malayi neuropeptide F receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0075 0.0013 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0315 0.0313 0.0301
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0315 0.0313 0.0301
Echinococcus granulosus g protein coupled receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis g protein coupled receptor 0.0315 0.0313 0.0301
Brugia malayi Dopamine receptor 0.0315 0.0313 0.0301
Chlamydia trachomatis dihydrofolate reductase 0.8036 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Loa Loa (eye worm) thymidylate synthase 0.1567 0.1885 0.1885
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0227 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1567 0.1885 0.1874
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.8036 1 1
Brugia malayi larval opioid receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni neuropeptide receptor 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Giardia lamblia Kinase, CMGC CDK 0.0075 0.0013 0.5
Echinococcus multilocularis fmrfamide receptor 0.0315 0.0313 0.0301
Echinococcus granulosus orexin receptor type 2 0.0315 0.0313 0.0301
Leishmania major dihydrofolate reductase-thymidylate synthase 0.5416 0.6713 1
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0315 0.0313 0.0301
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.0313 0.0301
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0315 0.0313 0.0301
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0315 0.0313 0.0301
Echinococcus multilocularis G-protein coupled receptor, putative 0.0315 0.0313 0.0301
Echinococcus multilocularis glutathione S transferase 0.0077 0.0016 0.0003
Schistosoma mansoni neuropeptide receptor 0.0315 0.0313 0.0301
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.0477 0.0692
Schistosoma mansoni glutathione-S-transferase 0.0077 0.0016 0.0003
Echinococcus granulosus neuropeptide receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni histamine h1 receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis neuropeptides capa receptor 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Loa Loa (eye worm) melatonin receptor type 1A 0.0315 0.0313 0.0313
Schistosoma mansoni opsin-like receptor 0.0315 0.0313 0.0301
Schistosoma mansoni opsin-like receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi sulfakinin receptor protein 0.0315 0.0313 0.0301
Brugia malayi RE15519p 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.8036 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni opsin-like receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Brugia malayi Dihydrofolate reductase 0.8036 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.0313 0.0301
Echinococcus multilocularis g protein coupled receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0315 0.0313 0.0313
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.0477 0.0464
Plasmodium falciparum glutathione S-transferase 0.0077 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus neuropeptide FF receptor 2 0.0315 0.0313 0.0301
Schistosoma mansoni myosin xvIII 0.0315 0.0313 0.0301
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.0313 0.0301
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0315 0.0313 0.0301
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0077 0.0016 0.0003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0315 0.0313 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni neuropeptide F-like receptor 0.0315 0.0313 0.0301
Echinococcus granulosus dro:myosuppressin receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis serotonin receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis G protein coupled receptor 139 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus sex peptide receptor 0.0315 0.0313 0.0301
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Brugia malayi G protein-coupled receptor 0.0315 0.0313 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Brugia malayi follicle stimulating hormone receptor 0.0315 0.0313 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0746 0.0854 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0315 0.0313 0.0301
Echinococcus granulosus tachykinin peptides receptor 99D 0.0315 0.0313 0.0301
Schistosoma mansoni neuropeptide receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni neuropeptide receptor 0.0315 0.0313 0.0301
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0315 0.0313 0.0301
Echinococcus granulosus allatostatin A receptor 0.0315 0.0313 0.0301
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0315 0.0313 0.0301
Brugia malayi G-protein coupled receptor 0.0315 0.0313 0.0301
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0315 0.0313 0.0301
Brugia malayi glutathione transferase 0.0402 0.0424 0.0411
Echinococcus granulosus dihydrofolate reductase 0.8036 1 1
Echinococcus granulosus thymidylate synthase 0.1567 0.1885 0.1874
Brugia malayi G protein-coupled receptor F59B2.13 0.0315 0.0313 0.0301
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.5416 0.6713 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi Serotonin receptor 0.0315 0.0313 0.0301
Brugia malayi Dopamine receptor protein 2 0.0315 0.0313 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus g protein coupled receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus glutathione S transferase Mu 1 0.0077 0.0016 0.0003
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1567 0.1885 0.1127
Schistosoma mansoni hypothetical protein 0.0315 0.0313 0.0301
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0077 0.0016 0.0003
Echinococcus multilocularis neuropeptide receptor A26 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni hypothetical protein 0.0315 0.0313 0.0301
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0315 0.0313 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.0313 0.0301
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0315 0.0313 0.0301
Echinococcus granulosus serotonin receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0075 0.0013 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Echinococcus multilocularis neuropeptides capa receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) neuropeptide F receptor 0.0315 0.0313 0.0313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Echinococcus granulosus neuropeptide Y receptor 0.0315 0.0313 0.0301
Echinococcus granulosus neuropeptides capa receptor 0.0315 0.0313 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi AKH receptor 0.0315 0.0313 0.0301
Schistosoma mansoni adenoreceptor 0.0315 0.0313 0.0301
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.0313 0.0301
Echinococcus granulosus neuropeptide receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis neuropeptide receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus g protein coupled receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus 7tm_1 domain containing protein 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis dihydrofolate reductase 0.8036 1 1
Brugia malayi neuropeptide F receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0315 0.0313 0.0301
Echinococcus granulosus neuropeptides capa receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0315 0.0313 0.0301
Echinococcus granulosus fmrfamide receptor 0.0315 0.0313 0.0301
Brugia malayi thymidylate synthase 0.1567 0.1885 0.1874
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0746 0.0854 0.0842
Schistosoma mansoni biogenic amine (5HT) receptor 0.0315 0.0313 0.0301
Schistosoma mansoni growth hormone secretagogue receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis glutathione S transferase 0.0077 0.0016 0.0003
Echinococcus granulosus biogenic amine 5HT receptor 0.0315 0.0313 0.0301
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0315 0.0313 0.0301
Echinococcus multilocularis thymidylate synthase 0.1567 0.1885 0.1874
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Entamoeba histolytica cell division protein kinase 2, putative 0.0075 0.0013 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Brugia malayi Dopamine receptor protein 1 0.0315 0.0313 0.0301
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.5416 0.6713 1
Echinococcus multilocularis neuropeptide Y receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus hypothetical protein 0.0315 0.0313 0.0301
Echinococcus granulosus g-protein coupled receptor 0.0315 0.0313 0.0301
Loa Loa (eye worm) G-protein coupled receptor 0.0315 0.0313 0.0313
Echinococcus granulosus G protein coupled receptor 139 0.0315 0.0313 0.0301
Schistosoma mansoni amine GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.0313 0.0301
Echinococcus granulosus somatostatin receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis glutathione S transferase 0.0077 0.0016 0.0003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.5416 0.6713 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Echinococcus multilocularis neuropeptide s receptor 0.0315 0.0313 0.0301
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.8036 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.0313 0.0301
Schistosoma mansoni neuropeptide F-like receptor 0.0315 0.0313 0.0301
Brugia malayi Tachykinin-like peptides receptor 99D 0.0315 0.0313 0.0301
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0075 0.0013 0.0013
Echinococcus multilocularis allatostatin A receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis glutathione S-transferase 0.0077 0.0016 0.0003
Brugia malayi hypothetical protein 0.0315 0.0313 0.0301
Echinococcus multilocularis somatostatin receptor 0.0315 0.0313 0.0301
Schistosoma mansoni alpha-1 adrenergic receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis neuropeptide receptor 0.0315 0.0313 0.0301
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0315 0.0313 0.0301
Echinococcus multilocularis serotonin receptor 0.0315 0.0313 0.0301
Echinococcus granulosus 7TM GPCR rhodopsin 0.0315 0.0313 0.0301
Echinococcus multilocularis g-protein coupled receptor 0.0315 0.0313 0.0301
Schistosoma mansoni hypothetical protein 0.0315 0.0313 0.0301
Plasmodium vivax glutathione S-transferase, putative 0.0077 0.0016 0.0004
Loa Loa (eye worm) TYRA-2 protein 0.0315 0.0313 0.0313
Loa Loa (eye worm) G-protein coupled receptor 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Giardia lamblia Kinase, CMGC CDK 0.0075 0.0013 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0315 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0315 0.0313 0.0313
Schistosoma mansoni biogenic amine receptor 0.0315 0.0313 0.0301

Activities

Activity type Activity value Assay description Source Reference
Ki 0.5 (binding) = 120 nM Binding affinity against Sigma receptor type 3 by using [3H]-DTG as radioligand ChEMBL. 7562917
Ki 0.5 (binding) = 120 nM Binding affinity against Sigma receptor type 3 by using [3H]-DTG as radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 1000 nM Binding affinity against Dopamine receptor D3 by using [3H]- radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 1000 nM Binding affinity against Dopamine receptor D3 by using [3H]- radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 5000 nM Binding affinity against Dopamine receptor D1 by using [3H]-SCH-23,390 as radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 5000 nM Binding affinity against Dopamine receptor D2 by using [3H]- radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 5000 nM Binding affinity against Dopamine receptor D1 by using [3H]-SCH-23,390 as radioligand ChEMBL. 7562917
Ki 0.5 (binding) > 5000 nM Binding affinity against Dopamine receptor D2 by using [3H]- radioligand ChEMBL. 7562917
Ratio (binding) = 970 Binding affinity and ratio for sigma-1/sigma-2 receptor with [3H]-DTG ChEMBL. 7562917

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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