Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0791 | 0.9641 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0791 | 0.9641 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0165 | 0.0359 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0141 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0165 | 0.0359 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 nM | Displacement of [3H]-TTNPB from RARgamma/RXRalpha (unknown origin) expressed in baculovirus expression system by scintillation proximity assay | ChEMBL. | 27261179 |
Ki (ADMET) | = 87 nM | Displacement of [3H]-TTNPB from RARalpha/RXRalpha (unknown origin) expressed in baculovirus expression system by scintillation proximity assay | ChEMBL. | 27261179 |
Ki (binding) | = 131 nM | Displacement of [3H]-TTNPB from RARbeta/RXRalpha (unknown origin) expressed in baculovirus expression system by scintillation proximity assay | ChEMBL. | 27261179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.