Detailed information for compound 220093

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.49 | Formula: C20H17N2O4S2-
  • H donors: 1 H acceptors: 5 LogP: 4.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@@H]1C(=O)C2[C@H]1[C@H](C)C(=C2C(=O)[O-])Sc1csc2n1c1ccccc1n2)O
  • InChi: 1S/C20H18N2O4S2/c1-8-13-14(9(2)23)17(24)15(13)16(19(25)26)18(8)28-12-7-27-20-21-10-5-3-4-6-11(10)22(12)20/h3-9,13-15,23H,1-2H3,(H,25,26)/p-1/t8-,9+,13-,14-,15?/m1/s1
  • InChiKey: CJACMBWFDMGQOZ-NNLCFRSYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0387 0.0567
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0171 0.6829 1
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0171 0.6829 0.6829
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.5076 0.7247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0333 0.0487
Onchocerca volvulus AMP deaminase 2 homolog 0.0056 0.1752 0.2119
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.1704 0.237
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0056 0.1752 0.2566
Trypanosoma brucei AMP deaminase, putative 0.0056 0.1752 0.334
Schistosoma mansoni hypothetical protein 0.0131 0.5076 0.7433
Toxoplasma gondii AMP deaminase 0.0056 0.1752 0.2566
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0387 0.0567
Onchocerca volvulus 0.0055 0.1704 0.2044
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0112 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.5076 0.7247
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0387 0.0567
Plasmodium vivax adenosine/AMP deaminase, putative 0.0056 0.1752 0.2566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0824 0.1206
Onchocerca volvulus 0.0038 0.0974 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0056 0.1752 0.334
Treponema pallidum adenosine deaminase 0.0171 0.6829 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0974 0.1427
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.1216 0.1187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0135 0.5246 0.7683
Loa Loa (eye worm) hypothetical protein 0.0026 0.046 0.0518
Schistosoma mansoni adenosylhomocysteinase 0.0084 0.298 0.4363
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.1216 0.1286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0974 0.0974
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0068
Plasmodium vivax GMP synthetase, putative 0.0059 0.1882 0.2755
Trypanosoma brucei AMP deaminase, putative 0.0056 0.1752 0.334
Brugia malayi beta-lactamase family protein 0.0038 0.0974 0.0911
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.1216 0.2317
Mycobacterium leprae Probable lipase LipE 0.0038 0.0974 0.1427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0387 0.0387
Loa Loa (eye worm) intermediate filament protein 0.0055 0.1704 0.237
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0974 0.0974
Onchocerca volvulus 0.0038 0.0974 0.0911
Trypanosoma cruzi AMP deaminase 2, putative 0.0056 0.1752 0.334
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0387 0.0567
Echinococcus granulosus lamin 0.0055 0.1704 0.1953
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Echinococcus multilocularis lamin 0.0055 0.1704 0.1953
Trypanosoma cruzi AMP deaminase, putative 0.0056 0.1752 0.334
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0587 0.0311
Schistosoma mansoni adenosylhomocysteinase 0.0084 0.298 0.4363
Mycobacterium ulcerans GMP synthase 0.0059 0.1882 0.2755
Brugia malayi beta-lactamase 0.0038 0.0974 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1216 0.178
Plasmodium falciparum adenosylhomocysteinase 0.0135 0.5246 0.7683
Loa Loa (eye worm) beta-lactamase 0.0038 0.0974 0.1283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0068
Leishmania major AMP deaminase, putative 0.0056 0.1752 0.2566
Onchocerca volvulus 0.0055 0.1704 0.2044
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0135 0.5246 0.7683
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0387 0.0567
Trichomonas vaginalis adenosine deaminase, putative 0.0171 0.6829 1
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0059 0.1882 0.2755
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0387 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0433 0.0634
Loa Loa (eye worm) hypothetical protein 0.0115 0.4376 0.6348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0444 0.0651
Plasmodium falciparum AMP deaminase, putative 0.0056 0.1752 0.2566
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0974 0.0911
Loa Loa (eye worm) hypothetical protein 0.0059 0.1882 0.2634
Schistosoma mansoni thyroid hormone receptor 0.0142 0.5539 0.8112
Plasmodium vivax adenosine deaminase, putative 0.0171 0.6829 1
Mycobacterium tuberculosis Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase) 0.0022 0.025 0.025
Entamoeba histolytica adenosine deaminase, putative 0.0171 0.6829 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0974 0.1427
Loa Loa (eye worm) hypothetical protein 0.0025 0.0387 0.0409
Echinococcus multilocularis AMP deaminase 2 0.0056 0.1752 0.2029
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0056 0.1752 0.2566
Loa Loa (eye worm) hypothetical protein 0.0115 0.4376 0.6348
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Echinococcus granulosus AMP deaminase 2 0.0056 0.1752 0.2029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0824 0.1206
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0206 0.0392
Mycobacterium ulcerans hypothetical protein 0.0038 0.0974 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0444 0.0651
Echinococcus granulosus lamin dm0 0.0055 0.1704 0.1953
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0825 0.1573
Schistosoma mansoni adenosine deaminase 0.0171 0.6829 1
Trichomonas vaginalis esterase, putative 0.0038 0.0974 0.1427
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0025 0.0416 0.0452
Loa Loa (eye worm) hypothetical protein 0.0025 0.0416 0.0452
Schistosoma mansoni adenosylhomocysteinase 0.0084 0.298 0.4363
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0387 0.0387
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.1216 0.178
Loa Loa (eye worm) hypothetical protein 0.0115 0.4376 0.6348
Mycobacterium ulcerans hypothetical protein 0.0025 0.0387 0.0567
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0974 0.1857
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0135 0.5246 0.7683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0334 0.0489
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0135 0.5246 0.7683
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0135 0.5246 0.5246
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0059 0.1882 0.3586
Entamoeba histolytica AMP deaminase, putative 0.0056 0.1752 0.2566
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0387 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0824 0.1206
Trypanosoma cruzi AMP deaminase, putative 0.0056 0.1752 0.334
Mycobacterium ulcerans adenosine deaminase 0.0171 0.6829 1
Schistosoma mansoni thyroid hormone receptor 0.0142 0.5539 0.8112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1216 0.178
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0056 0.1752 0.334
Schistosoma mansoni lamin 0.0055 0.1704 0.2495
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0112 0.0112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0587 0.0708
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0171 0.6829 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0974 0.1427
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0974 0.0808
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.1216 0.2317
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0135 0.5246 0.7683
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0974 0.0974
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0387 0.0567
Loa Loa (eye worm) hypothetical protein 0.0056 0.1752 0.2442
Onchocerca volvulus 0.0056 0.1752 0.2119
Echinococcus multilocularis musashi 0.0055 0.1704 0.1953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0334 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0974 0.1857
Toxoplasma gondii adenosylhomocysteinase, putative 0.0135 0.5246 0.7683
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0825 0.1208
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0974 0.1427
Mycobacterium tuberculosis Conserved protein 0.0038 0.0974 0.0974
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0095 0.0182
Mycobacterium ulcerans lipase LipD 0.0038 0.0974 0.1427
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0387 0.0567
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0059 0.1882 0.2232
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0059 0.1882 0.2755
Schistosoma mansoni AMP deaminase 0.0056 0.1752 0.2566
Schistosoma mansoni lamin 0.0055 0.1704 0.2495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0334 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.1216 0.1643
Toxoplasma gondii ABC1 family protein 0.0038 0.0974 0.1427
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0974 0.0974
Mycobacterium leprae Probable GMP synthase [glutamine-hydrolyzing] GuaA (Glutamine amidotransferase) (GMP synthetase) 0.0022 0.025 0.0367
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0387 0.0567
Loa Loa (eye worm) hypothetical protein 0.0025 0.0387 0.0409
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.1216 0.178
Brugia malayi intermediate filament protein 0.0055 0.1704 0.2044
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0042 0.1166 0.1708
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0974 0.1427
Echinococcus multilocularis adenosylhomocysteinase 0.0135 0.5246 0.7515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0936 0.137
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0135 0.5246 0.7683
Entamoeba histolytica adenosine deaminase, putative 0.0171 0.6829 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Trypanosoma cruzi GMP synthase, putative 0.0019 0.0153 0.0291
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.1216 0.178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0444 0.0651
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.1216 0.178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0068
Brugia malayi Adenosine/AMP deaminase family protein 0.0171 0.6829 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0334 0.0489
Leishmania major adenine aminohydrolase 0.0171 0.6829 1
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0135 0.5246 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0112 0.0164
Loa Loa (eye worm) hypothetical protein 0.0115 0.4376 0.6348
Schistosoma mansoni intermediate filament proteins 0.0055 0.1704 0.2495
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0387 0.0567
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0825 0.1573
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.1216 0.2317
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0974 0.1283
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0974 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1216 0.178
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0112 0.0164
Plasmodium falciparum adenosine deaminase 0.0171 0.6829 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0824 0.1206
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0171 0.6829 1
Trypanosoma cruzi AMP deaminase, putative 0.0056 0.1752 0.334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0387 0.0567
Entamoeba histolytica AMP deaminase, putative 0.0056 0.1752 0.2566
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0725 0.1061
Onchocerca volvulus 0.0038 0.0974 0.0911
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0387 0.0567
Schistosoma mansoni adenosylhomocysteinase 0.0084 0.298 0.4363
Brugia malayi GMP synthase 0.0059 0.1882 0.232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0543 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0974 0.1427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.5539 0.7975
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0387 0.0567
Leishmania major S-adenosylhomocysteine hydrolase 0.0135 0.5246 0.7683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0333 0.0487
Echinococcus multilocularis lamin dm0 0.0055 0.1704 0.1953
Mycobacterium tuberculosis Conserved protein 0.0038 0.0974 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0056 0.1752 0.2566
Entamoeba histolytica adenosylhomocysteinase, putative 0.0135 0.5246 0.7683
Onchocerca volvulus Adenosine deaminase homolog 0.0171 0.6829 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0974 0.1427
Loa Loa (eye worm) hypothetical protein 0.0038 0.0974 0.1283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0725 0.1061
Schistosoma mansoni adenosylhomocysteinase 0.0135 0.5246 0.7683
Echinococcus granulosus intermediate filament protein 0.0055 0.1704 0.1953
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0056 0.1752 0.334
Loa Loa (eye worm) hypothetical protein 0.0054 0.166 0.2304
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0974 0.1427
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.1216 0.178
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0059 0.1882 0.2232
Trypanosoma cruzi AMP deaminase, putative 0.0056 0.1752 0.334
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0059 0.1882 0.2755
Leishmania major hypothetical protein, conserved 0.0056 0.1752 0.2566
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0135 0.5246 1
Wolbachia endosymbiont of Brugia malayi GMP synthase 0.0043 0.1181 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0974 0.1427
Giardia lamblia GTOR 0.0044 0.1216 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.1216 0.2317
Loa Loa (eye worm) hypothetical protein 0.0171 0.6829 1
Echinococcus multilocularis adenosine deaminase 0.0171 0.6829 1
Brugia malayi Adenosylhomocysteinase 0.0135 0.5246 0.7543
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0135 0.5246 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0974 0.1427
Echinococcus granulosus adenosine deaminase 0.0171 0.6829 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0585 0.0856
Loa Loa (eye worm) adenosylhomocysteinase 0.0135 0.5246 0.7644
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.1216 0.1187
Loa Loa (eye worm) hypothetical protein 0.0055 0.1704 0.237
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0387 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0433 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0333 0.0487
Trypanosoma cruzi AMP deaminase, putative 0.0056 0.1752 0.334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0387 0.0409
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.1704 0.2044
Trypanosoma brucei AMP deaminase, putative 0.0056 0.1752 0.334
Schistosoma mansoni GMP synthetase 0.0059 0.1882 0.2755
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0974 0.0974
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0974 0.1857
Brugia malayi adenosine monophosphate deaminase 0.0056 0.1752 0.2119
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0112 0.0164
Leishmania major hypothetical protein, conserved 0.0038 0.0974 0.1427
Loa Loa (eye worm) AMP deaminase 0.0056 0.1752 0.2442
Trypanosoma cruzi GMP synthase [glutamine-hydrolysing] 0.0043 0.1181 0.2251
Schistosoma mansoni adenosine deaminase-related 0.0171 0.6829 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0974 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0824 0.1206
Echinococcus granulosus adenosylhomocysteinase 0.0135 0.5246 0.7515
Mycobacterium tuberculosis Conserved protein 0.0038 0.0974 0.0974
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0974 0.1427
Trichomonas vaginalis adenosine deaminase, putative 0.0171 0.6829 1
Brugia malayi beta-lactamase family protein 0.0038 0.0974 0.0911
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0974 0.1427

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antibacterial activity of the compound against MRSA was determined; Active ChEMBL. 8831751

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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