Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.2755 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.0643 | 0.1966 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.0643 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.0643 | 0.1966 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0122 | 0.0195 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.0643 | 0.1966 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0123 | 0.4724 | 0.7581 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.0643 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0155 | 0.0155 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0123 | 0.4724 | 0.7581 |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.0643 | 0.1966 |
Leishmania major | trypanothione reductase | 0.0076 | 0.2755 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0277 | 0.0445 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0126 | 0.0202 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.2755 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.0346 | 0.0346 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.0643 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0643 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 0.2755 | 0.2755 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0122 | 0.0122 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.2755 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0126 | 0.0202 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.0643 | 0.1966 |
Echinococcus granulosus | cyclin dependent kinase 19 | 0.0158 | 0.6231 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.2755 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Echinococcus granulosus | cyclin | 0.0123 | 0.4724 | 0.7581 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.0643 | 0.5 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0014 | 0.0126 | 0.0126 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0277 | 0.0445 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.0643 | 0.1966 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.0643 | 0.1966 |
Brugia malayi | Sushi domain | 0.0014 | 0.0126 | 0.0126 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.2755 | 1 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0155 | 0.025 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.2755 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0123 | 0.4724 | 0.4724 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0123 | 0.4724 | 0.4724 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0022 | 0.0452 | 0.0452 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.0643 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.0643 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0277 | 0.0277 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0643 | 0.5 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0014 | 0.0126 | 0.0126 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0247 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0145 | 0.0233 |
Loa Loa (eye worm) | CMGC/CDK/CDK8 protein kinase | 0.0158 | 0.6231 | 0.6231 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0126 | 0.0202 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.0643 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.0643 | 0.0643 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0126 | 0.0202 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0155 | 0.0155 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.2755 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 0.2755 | 0.2755 |
Loa Loa (eye worm) | cyclin C | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.0643 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.2755 | 0.4421 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.0643 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.0643 | 0.0643 |
Brugia malayi | glutathione reductase | 0.0076 | 0.2755 | 0.2755 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.2755 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0155 | 0.0155 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.2755 | 0.4421 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0452 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0194 | 0.0194 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.0643 | 0.1032 |
Echinococcus multilocularis | cyclin | 0.0123 | 0.4724 | 0.7581 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.0643 | 0.1032 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0122 | 0.0195 |
Entamoeba histolytica | cyclin C, putative | 0.0124 | 0.4799 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.6231 | 0.6231 |
Loa Loa (eye worm) | gastrulation defective protein 1 | 0.0157 | 0.6207 | 0.6207 |
Echinococcus multilocularis | cyclin dependent kinase 19 | 0.0158 | 0.6231 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.6231 | 0.6231 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.0346 | 0.0346 |
Onchocerca volvulus | 0.0014 | 0.0126 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.0126 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0643 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.2755 | 0.2755 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 nM | Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay | ChEMBL. | 26985305 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.