Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0243 | 0.0737 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0757 | 0.5792 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0757 | 0.5792 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0243 | 0.0737 | 0.0737 |
Echinococcus granulosus | thymidylate synthase | 0.0243 | 0.0737 | 0.0737 |
Echinococcus granulosus | dihydrofolate reductase | 0.1186 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0757 | 0.5792 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0757 | 0.5792 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1186 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0168 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1186 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0757 | 0.5792 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0757 | 0.5792 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1186 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0243 | 0.0737 | 0.0737 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1186 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1186 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0243 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | thymidylate synthase | 0.0243 | 0.0737 | 0.0737 |
Brugia malayi | Dihydrofolate reductase | 0.1186 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1186 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1186 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 21 uM | Inhibitory activity against plasmodium falciparum cyclin dependent protein kinase, Pfmrk | ChEMBL. | 12930149 |
IC50 (binding) | > 21 uM | Inhibitory activity against plasmodium falciparum cyclin dependent protein kinase, Pfmrk | ChEMBL. | 12930149 |
IC50 (functional) | = 21 uM | Antimicrobial activity against Plasmodium falciparum | ChEMBL. | 20185316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.