Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Salmonella enterica subsp. enterica serovar Typhi | Dihydrofolate reductase | Starlite/ChEMBL | References |
Gallus gallus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 6.45 | Inhibitory activity against dihydrofolate reductase | ChEMBL. | 11495588 |
Activity (binding) | = 6.45 | Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 | ChEMBL. | 1507206 |
Ki (binding) | = 4.83 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 6.19 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 6.45 | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Ki (binding) | = 6.45 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Log (binding) | = 6.45 1/Ki | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Log 1/C (binding) | = 4.05 | The concentration of the compound required to inhibit dihydrofolate reductase in rat liver | ChEMBL. | 6737433 |
Log 1/C (binding) | = 4.83 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver dihydrofolate reductase. | ChEMBL. | 6345782 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver dehydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver Dihydrofolate reductase. | ChEMBL. | 7277386 |
Log 1/C (binding) | = 4.05 | The concentration of the compound required to inhibit dihydrofolate reductase in rat liver | ChEMBL. | 6737433 |
Log 1/C (functional) | = 4.56 | Inhibitory activity against murine tumor cells (L5178Y/R) | ChEMBL. | 7086836 |
Log 1/C (binding) | = 4.83 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver dihydrofolate reductase. | ChEMBL. | 6345782 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver Dihydrofolate reductase. | ChEMBL. | 7277386 |
Log 1/C (binding) | = 5.1 | Inhibition of bovine liver dehydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/C (functional) | = 5.37 | Inhibitory activity against murine tumor cells (L5178Y/S) | ChEMBL. | 7086836 |
Log 1/C (binding) | = 6.45 | Inhibition of dihydrofolate reductase (DHFR) from E. coli. | ChEMBL. | 3882967 |
Log 1/C (binding) | = 6.45 | In vitro inhibition of E. Coli dihydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/Ki (binding) | = 4.83 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki (binding) | = 6.19 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki app (binding) | = 4.83 | Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 5.1 | Inhibition of dihydrofolate reductase from bovine liver | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 5.6 | Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 6.19 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 4.83 | Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 5.1 | Inhibition of dihydrofolate reductase from bovine liver | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 5.6 | Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 6.19 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 6.45 | Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 6.45 | Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase | ChEMBL. | 3276891 |
Log 1/Ki app (binding) | = 6.45 | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log Ki (binding) | = 6.45 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
log(1/I50) (binding) | = 5.1 | Inhibition of bovine liver dihydrofolate reductase using dihydrofolic acid as substrate | ChEMBL. | 458817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
16 literature references were collected for this gene.