Detailed information for compound 220377

Basic information

Technical information
  • TDR Targets ID: 220377
  • Name: 2-[1-(benzenesulfonyl)-5-methoxy-2-methylindo l-3-yl]-N,N-dimethylethanamine
  • MW: 372.481 | Formula: C20H24N2O3S
  • H donors: 0 H acceptors: 2 LogP: 3.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(CCN(C)C)c(n2S(=O)(=O)c1ccccc1)C
  • InChi: 1S/C20H24N2O3S/c1-15-18(12-13-21(2)3)19-14-16(25-4)10-11-20(19)22(15)26(23,24)17-8-6-5-7-9-17/h5-11,14H,12-13H2,1-4H3
  • InChiKey: DNOJEKLHKJAPCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[1-(benzenesulfonyl)-5-methoxy-2-methyl-indol-3-yl]-N,N-dimethyl-ethanamine
  • 2-[1-(benzenesulfonyl)-5-methoxy-2-methyl-3-indolyl]-N,N-dimethylethanamine
  • 2-[5-methoxy-2-methyl-1-(phenylsulfonyl)indol-3-yl]-N,N-dimethyl-ethanamine
  • 2-(1-besyl-5-methoxy-2-methyl-indol-3-yl)ethyl-dimethyl-amine
  • 2-(5-methoxy-2-methyl-1-phenylsulfonylindol-3-yl)-N,N-dimethylethanamine
  • 2-(5-methoxy-2-methyl-1-phenylsulfonyl-indol-3-yl)-N,N-dimethyl-ethanamine
  • 2-(5-methoxy-2-methyl-1-phenylsulfonyl-3-indolyl)-N,N-dimethylethanamine
  • 2-(5-methoxy-2-methyl-1-phenylsulfonyl-indol-3-yl)ethyl-dimethyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0231 0.1889 0.1797
Echinococcus granulosus cathepsin b 0.102 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0312 0.2722 0.4869
Giardia lamblia Cathepsin B precursor 0.0405 0.3677 1
Schistosoma mansoni cathepsin s 0.0182 0.1392 0.1392
Onchocerca volvulus Cathepsin L homolog 0.0129 0.0846 0.1546
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0058 0.0112 0.0112
Onchocerca volvulus Cathepsin F homolog 0.0579 0.5473 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Echinococcus granulosus cathepsin L cysteine proteinase 0.0579 0.5473 0.5422
Brugia malayi cathepsin L precursor 0.0129 0.0846 0.0846
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0846 0.0846
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0229 0.1876 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0129 0.0846 0.0846
Trypanosoma cruzi cruzipain precursor, putative 0.0579 0.5473 0.5422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0846 0.137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0182 0.1392 0.1295
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0846 0.0846
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0312 0.2722 0.264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0846 0.137
Entamoeba histolytica cysteine proteinase, putative 0.0312 0.2722 0.4869
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0846 0.0846
Giardia lamblia Cathepsin B precursor 0.0405 0.3677 1
Toxoplasma gondii cathepsin B 0.0405 0.3677 0.6651
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0405 0.3677 0.3677
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0312 0.2722 0.2722
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0229 0.1876 0.3291
Schistosoma mansoni cathepsin F (C01 family) 0.0397 0.3597 0.3597
Echinococcus granulosus cathepsin b 0.102 1 1
Plasmodium falciparum serine repeat antigen 6 0.0129 0.0846 0.137
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0846 0.137
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Schistosoma mansoni hypothetical protein 0.0177 0.1334 0.1334
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0229 0.1876 0.3291
Loa Loa (eye worm) cysteine protease 0.0579 0.5473 0.5422
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Plasmodium vivax unspecified product 0.0182 0.1392 0.2388
Loa Loa (eye worm) hypothetical protein 0.0182 0.1392 0.1295
Plasmodium falciparum serine repeat antigen 2 0.0129 0.0846 0.137
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1005 0.9852 0.985
Loa Loa (eye worm) hypothetical protein 0.0182 0.1392 0.1295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0579 0.5473 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.102 1 1
Brugia malayi hypothetical protein 0.0231 0.1889 0.1889
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0846 0.137
Brugia malayi fibroinase precursor 0.0129 0.0846 0.0846
Echinococcus granulosus geminin 0.0177 0.1334 0.1236
Echinococcus multilocularis cathepsin L 0.0312 0.2722 0.264
Schistosoma mansoni hypothetical protein 0.0177 0.1334 0.1334
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0579 0.5473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Loa Loa (eye worm) hypothetical protein 0.0397 0.3597 0.3525
Brugia malayi Cathepsin L-like precursor 0.0182 0.1392 0.1392
Onchocerca volvulus 0.0579 0.5473 1
Entamoeba histolytica cysteine proteinase, putative 0.0397 0.3597 0.6501
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.102 1 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Echinococcus granulosus microtubule associated protein 2 0.072 0.6919 0.6885
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.102 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.3597 0.3525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0058 0.0112 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0579 0.5473 0.5422
Brugia malayi Cathepsin L-like cysteine proteinase 0.0397 0.3597 0.3597
Onchocerca volvulus 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Entamoeba histolytica cysteine proteinase, putative 0.0579 0.5473 1
Echinococcus multilocularis cysteine protease 0.0579 0.5473 0.5422
Brugia malayi Cathepsin L-like precursor 0.0397 0.3597 0.3597
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Toxoplasma gondii cathepsin CPL 0.0579 0.5473 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0154 0.0154
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.0182 0.1392 0.1295
Entamoeba histolytica cysteine proteinase, putative 0.0312 0.2722 0.4869
Schistosoma mansoni cathepsin S (C01 family) 0.0129 0.0846 0.0846
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0129 0.0846 0.137
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.102 1 1
Echinococcus granulosus cysteine protease 0.0312 0.2722 0.264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0229 0.1876 0.1784
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Entamoeba histolytica cysteine proteinase, putative 0.0312 0.2722 0.4869
Loa Loa (eye worm) polyprenyl synthetase 0.0229 0.1876 0.1784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Treponema pallidum octaprenyl-diphosphate synthase 0.0058 0.0112 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0397 0.3597 0.3525
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0397 0.3597 0.3525
Echinococcus granulosus tm gpcr rhodopsin 0.1005 0.9852 0.985
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0229 0.1876 0.1876
Entamoeba histolytica cysteine proteinase 1, putative 0.0312 0.2722 0.4869
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0129 0.0846 0.0743
Trypanosoma cruzi cysteine peptidase, putative 0.0312 0.2722 0.264
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0579 0.5473 0.5422
Brugia malayi cathepsin F-like cysteine proteinase 0.0182 0.1392 0.1392
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0579 0.5473 0.5422
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Onchocerca volvulus 0.0579 0.5473 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0229 0.1876 0.3291
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0405 0.3677 0.6651
Entamoeba histolytica cysteine proteinase, putative 0.0312 0.2722 0.4869
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0846 0.0846
Trypanosoma cruzi cysteine proteinase, putative 0.0312 0.2722 0.264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Brugia malayi cathepsin L-like precursor 0.0397 0.3597 0.3597
Plasmodium vivax vivapain-3 0.0312 0.2722 0.4869
Leishmania major cysteine peptidase A (CPA) 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0397 0.3597 0.5946
Echinococcus granulosus cathepsin l1 0.0579 0.5473 0.5422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Plasmodium falciparum serine repeat antigen 8 0.0129 0.0846 0.137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0129 0.0846 0.137
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0129 0.0846 0.137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0405 0.3677 0.3606
Onchocerca volvulus 0.0397 0.3597 0.6573
Loa Loa (eye worm) cathepsin B 0.0405 0.3677 0.3606
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0229 0.1876 1
Entamoeba histolytica cysteine proteinase, putative 0.0579 0.5473 1
Brugia malayi Papain family cysteine protease containing protein 0.0312 0.2722 0.2722
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Loa Loa (eye worm) ctsf protein 0.0579 0.5473 0.5422
Plasmodium falciparum serine repeat antigen 3 0.0129 0.0846 0.137
Plasmodium falciparum serine repeat antigen 4 0.0129 0.0846 0.137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0846 0.0743
Brugia malayi TAR-binding protein 0.0062 0.0154 0.0154
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0129 0.0846 0.137
Toxoplasma gondii preprocathepsin c precursor, putative 0.0129 0.0846 0.137
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0579 0.5473 1
Schistosoma mansoni microtubule-associated protein tau 0.072 0.6919 0.6919
Trypanosoma brucei cysteine peptidase C (CPC) 0.0405 0.3677 0.6651
Plasmodium falciparum serine repeat antigen 1 0.0129 0.0846 0.137
Brugia malayi Cathepsin L-like precursor 0.0397 0.3597 0.3597
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0154 0.0043
Echinococcus granulosus cathepsin l cysteine peptidase 0.0579 0.5473 0.5422
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0154 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Plasmodium vivax vivapain-1 0.0312 0.2722 0.4869
Onchocerca volvulus 0.0579 0.5473 1
Entamoeba histolytica cysteine proteinase 2 0.0312 0.2722 0.4869
Loa Loa (eye worm) RNA binding protein 0.0062 0.0154 0.0043
Giardia lamblia Farnesyl diphosphate synthase 0.0229 0.1876 0.3637
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0229 0.1876 0.1784
Brugia malayi Papain family cysteine protease containing protein 0.0579 0.5473 0.5473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0154 0.0154
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0229 0.1876 0.2225
Onchocerca volvulus 0.0579 0.5473 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0846 0.0846
Onchocerca volvulus Cathepsin L homolog 0.0579 0.5473 1
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0579 0.5473 1
Trypanosoma cruzi cysteine peptidase, putative 0.0579 0.5473 0.5422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0129 0.0846 0.137
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0154 0.0154
Plasmodium vivax vivapain-2 0.0579 0.5473 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0129 0.0846 0.0846
Brugia malayi Papain family cysteine protease containing protein 0.0312 0.2722 0.2722
Trypanosoma cruzi major cysteine proteinase, putative 0.0129 0.0846 0.0743
Echinococcus multilocularis cysteine protease 0.0579 0.5473 0.5422
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0058 0.0112 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0182 0.1392 0.1392
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0229 0.1876 0.1784
Schistosoma mansoni cathepsin F (C01 family) 0.0579 0.5473 0.5473
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0154 0.0043
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0129 0.0846 0.0846
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0229 0.1876 1
Onchocerca volvulus Cathepsin L homolog 0.0579 0.5473 1
Toxoplasma gondii cathepsin CPC1 0.0129 0.0846 0.137
Onchocerca volvulus 0.0579 0.5473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0312 0.2722 0.4869
Loa Loa (eye worm) hypothetical protein 0.0579 0.5473 0.5422
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0579 0.5473 1
Trypanosoma cruzi cysteine proteinase, putative 0.0312 0.2722 0.264
Loa Loa (eye worm) hypothetical protein 0.0129 0.0846 0.0743
Leishmania major farnesyl pyrophosphate synthase 0.0229 0.1876 0.3291
Plasmodium falciparum serine repeat antigen 9 0.0129 0.0846 0.137
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0405 0.3677 0.6119
Plasmodium vivax unspecified product 0.0129 0.0846 0.137
Brugia malayi Polyprenyl synthetase family protein 0.0058 0.0112 0.0112
Echinococcus multilocularis cathepsin b 0.102 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0129 0.0846 0.137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0154 0.0154
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Trypanosoma cruzi major cysteine proteinase, putative 0.0129 0.0846 0.0743
Schistosoma mansoni glutathione synthetase 0.0058 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0129 0.0846 0.137
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0129 0.0846 0.137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0312 0.2722 0.2722
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0229 0.1876 0.2225
Echinococcus multilocularis cathepsin L 0.0129 0.0846 0.0743
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0312 0.2722 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0182 0.1392 0.1295
Echinococcus granulosus cathepsin l1 0.0397 0.3597 0.3525
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0229 0.1876 0.2225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0129 0.0846 0.0846
Echinococcus granulosus cathepsin L 0.0312 0.2722 0.264
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0129 0.0846 0.137
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Entamoeba histolytica hypothetical protein 0.0129 0.0846 0.137
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Onchocerca volvulus 0.0579 0.5473 1
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0579 0.5473 0.5422
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0579 0.5473 0.5422
Schistosoma mansoni cathepsin B (C01 family) 0.0129 0.0846 0.0846
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0846 0.0846
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0229 0.1876 0.1784
Trypanosoma cruzi cysteine peptidase, putative 0.0579 0.5473 0.5422
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1889 0.1797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Giardia lamblia Cathepsin B precursor 0.0405 0.3677 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Schistosoma mansoni trans-prenyltransferase 0.0058 0.0112 0.0112
Plasmodium falciparum serine repeat antigen 5 0.0129 0.0846 0.137
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0846 0.0846
Echinococcus multilocularis microtubule associated protein 2 0.072 0.6919 0.6885
Echinococcus multilocularis cathepsin L cysteine protease 0.0579 0.5473 0.5422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.102 1 1
Brugia malayi Polyprenyl synthetase family protein 0.0229 0.1876 0.1876
Entamoeba histolytica cysteine protease, putative 0.0312 0.2722 0.4869
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0229 0.1876 0.3291
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Plasmodium vivax unspecified product 0.0312 0.2722 0.4869
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Trypanosoma cruzi cysteine protease, putative 0.0312 0.2722 0.264
Echinococcus multilocularis cathepsin L cysteine protease 0.0579 0.5473 0.5422
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0846 0.0846
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0846 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0058 0.0112 0.0112
Echinococcus granulosus cathepsin L 0.0129 0.0846 0.0743
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0129 0.0846 0.137
Schistosoma mansoni cathepsin F (C01 family) 0.0579 0.5473 0.5473
Plasmodium falciparum serine repeat antigen 7 0.0129 0.0846 0.137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0312 0.2722 0.2722
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0846 0.137
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0129 0.0846 0.0846
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0058 0.0112 0.5
Toxoplasma gondii cathepsin CPC2 0.0129 0.0846 0.137
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1889 0.1797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0579 0.5473 1
Brugia malayi Cathepsin L-like precursor 0.0579 0.5473 0.5473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0579 0.5473 1
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0846 0.0846
Echinococcus multilocularis cathepsin b 0.102 1 1
Leishmania major cathepsin L-like protease 0.0579 0.5473 1
Onchocerca volvulus 0.0129 0.0846 0.1546
Loa Loa (eye worm) fibroinase 0.0579 0.5473 0.5422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0579 0.5473 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.102 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0846 0.0846
Entamoeba histolytica cysteine protease, putative 0.0129 0.0846 0.137
Echinococcus multilocularis geminin 0.0177 0.1334 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0312 0.2722 0.4054
Echinococcus granulosus tar DNA binding protein 0.0062 0.0154 0.0043
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0846 0.137
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0129 0.0846 0.137
Schistosoma mansoni cathepsin C 0.0129 0.0846 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0312 0.2722 0.4869
Trypanosoma cruzi cysteine peptidase, putative 0.0579 0.5473 0.5422
Echinococcus granulosus cathepsin L cysteine protease 0.0312 0.2722 0.264
Brugia malayi RNA binding protein 0.0062 0.0154 0.0154
Entamoeba histolytica cysteine protease, putative 0.0579 0.5473 1
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0058 0.0112 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0397 0.3597 0.5946
Plasmodium vivax vivapain-2 0.0579 0.5473 1
Trypanosoma cruzi cruzipain precursor, putative 0.0182 0.1392 0.1295

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 12 nM Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells. ChEMBL. 11689074
Ki (binding) = 12 nM Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells. ChEMBL. 11689074

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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