Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.012 | 0.1999 | 0.1994 |
Treponema pallidum | catabolite gene activator | 0.0005 | 0.0006 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0452 | 0.7737 | 0.7736 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0047 | 0.0041 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0007 | 0.0047 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2448 | 0.2443 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0007 | 0.0047 | 0.0041 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0005 | 0.0006 | 0.0006 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.0285 | 0.065 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0547 | 0.0541 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0073 | 0.0067 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0005 | 0.0006 | 0.001 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0075 | 0.1219 | 0.1213 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0047 | 0.0047 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0005 | 0.0006 | 0.001 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0428 | 0.0663 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0605 | 0.0605 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0605 | 0.0605 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.012 | 0.1999 | 0.1999 |
Entamoeba histolytica | recQ family helicase, putative | 0.0011 | 0.0117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0465 | 0.0459 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0373 | 0.6374 | 1 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0075 | 0.1219 | 0.1213 |
Schistosoma mansoni | camp-dependent protein kinase regulatory chain | 0.0005 | 0.0006 | 0.0006 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.3926 | 0.9156 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2941 | 0.6855 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1219 | 0.1213 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0428 | 0.0428 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0583 | 1 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0428 | 0.0422 |
Onchocerca volvulus | 0.0231 | 0.3926 | 1 | |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0452 | 0.7737 | 0.7736 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0373 | 0.6374 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0105 | 0.0098 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0105 | 0.0098 |
Echinococcus granulosus | neuropeptide s receptor | 0.0452 | 0.7737 | 0.7736 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0047 | 0.0047 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0373 | 0.6374 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0073 | 0.0067 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0911 | 0.0905 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0007 | 0.0047 | 0.0041 |
Onchocerca volvulus | 0.012 | 0.1999 | 0.5083 | |
Echinococcus multilocularis | thymidylate synthase | 0.012 | 0.1999 | 0.1994 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0105 | 0.0098 |
Echinococcus granulosus | thymidylate synthase | 0.012 | 0.1999 | 0.1994 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0583 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0016 | 0.0209 | 0.0209 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0428 | 0.0422 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0005 | 0.0006 | 0.0006 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0073 | 0.0067 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0006 | 0.0022 | 0.0022 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.344 | 0.3436 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0057 | 0.0911 | 0.1421 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0005 | 0.0006 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0105 | 0.0098 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.4287 | 0.4284 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0105 | 0.0098 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0075 | 0.1219 | 0.1905 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0011 | 0.0117 | 0.0173 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0047 | 0.0047 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0007 | 0.0047 | 0.0096 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Toxoplasma gondii | endonuclease IV APN | 0.0075 | 0.1219 | 0.1913 |
Schistosoma mansoni | hypothetical protein | 0.0005 | 0.0006 | 0.0006 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0007 | 0.0047 | 0.0096 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0452 | 0.7737 | 0.7736 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0547 | 0.0541 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0506 | 0.1168 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0265 | 0.0258 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0005 | 0.0006 | 0.001 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0428 | 0.0422 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.041 | 0.0404 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0583 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0583 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0583 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0583 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0073 | 0.0073 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0009 | 0.0073 | 0.0067 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0005 | 0.0006 | 0.001 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0014 | 0.0168 | 0.0254 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0014 | 0.0165 | 0.0259 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0547 | 0.0541 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.0285 | 0.0278 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.4287 | 0.4284 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0007 | 0.0047 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0006 | 0.0022 | 0.0022 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0009 | 0.0073 | 0.0067 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.344 | 0.3436 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0007 | 0.0047 | 0.0047 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.012 | 0.1999 | 0.1994 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0005 | 0.0006 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0009 | 0.0073 | 0.0067 |
Mycobacterium ulcerans | endonuclease IV | 0.0075 | 0.1219 | 0.1213 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0009 | 0.0073 | 0.0067 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0007 | 0.0047 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0105 | 0.0098 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0009 | 0.0073 | 0.0104 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0428 | 0.0428 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0373 | 0.6374 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0105 | 0.0105 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.0285 | 0.0278 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.2787 | 0.7094 |
Loa Loa (eye worm) | thymidylate synthase | 0.012 | 0.1999 | 0.1994 |
Chlamydia trachomatis | endonuclease IV | 0.0075 | 0.1219 | 0.1213 |
Brugia malayi | Hypothetical 29.7 kDa protein C05D11.5 in chromosome III | 0.002 | 0.0265 | 0.0258 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.2448 | 0.2443 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.2448 | 0.2443 |
Mycobacterium ulcerans | epimerase | 0.002 | 0.0265 | 0.0258 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.4287 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0506 | 0.1168 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0073 | 0.0114 |
Onchocerca volvulus | 0.0029 | 0.0428 | 0.1077 | |
Schistosoma mansoni | camp-dependent protein kinase type II-alpha regulatory subunit | 0.0005 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2448 | 0.2443 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0075 | 0.1219 | 0.1905 |
Mycobacterium ulcerans | sugar phosphate isomerases/epimerases | 0.002 | 0.0265 | 0.0258 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0009 | 0.0073 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.0285 | 0.0278 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0005 | 0.0006 | 0.0006 |
Echinococcus granulosus | dihydrofolate reductase | 0.0583 | 1 | 1 |
Toxoplasma gondii | cAMP-dependent protein kinase regulatory subunit | 0.0005 | 0.0006 | 0.001 |
Schistosoma mansoni | cyclic nucleotide-gated ion channel | 0.0005 | 0.0006 | 0.0006 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0005 | 0.0006 | 0.0006 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0018 | 0.0241 | 0.0368 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0911 | 0.2113 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0428 | 0.0428 |
Schistosoma mansoni | camp-dependent protein kinase type II regulatory subunit | 0.0005 | 0.0006 | 0.0006 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.0285 | 0.065 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.0285 | 0.0278 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0428 | 0.0428 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0011 | 0.0117 | 0.0258 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0011 | 0.0117 | 0.0173 |
Mycobacterium leprae | conserved hypothetical protein | 0.002 | 0.0265 | 0.0258 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0005 | 0.0006 | 0.001 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0.0265 | 0.0258 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Onchocerca volvulus | Putative hydroxypyruvate isomerase | 0.002 | 0.0265 | 0.0659 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0007 | 0.0047 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0073 | 0.0073 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.2448 | 0.2443 |
Brugia malayi | Dihydrofolate reductase | 0.0583 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0428 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0073 | 0.0067 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0547 | 0.0541 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0005 | 0.0006 | 0.0006 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0373 | 0.6374 | 1 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0005 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0057 | 0.0911 | 0.0905 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0373 | 0.6374 | 1 |
Mycobacterium leprae | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) | 0.0075 | 0.1219 | 0.1213 |
Mycobacterium ulcerans | thymidylate synthase | 0.012 | 0.1999 | 0.1994 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0047 | 0.0047 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.2448 | 0.2443 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0265 | 0.0258 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0428 | 0.0672 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2941 | 0.6855 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0428 | 0.0422 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0011 | 0.0117 | 0.0173 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0007 | 0.0047 | 0.0041 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0007 | 0.0047 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0212 | 0.0205 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0005 | 0.0006 | 0.0006 |
Brugia malayi | thymidylate synthase | 0.012 | 0.1999 | 0.1994 |
Schistosoma mansoni | similar to Protein C20orf152 homolog | 0.0005 | 0.0006 | 0.0006 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0073 | 0.0114 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0583 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0105 | 0.0105 |
Treponema pallidum | catabolite gene activator (Crp) | 0.0005 | 0.0006 | 1 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0005 | 0.0006 | 0.0006 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0007 | 0.0047 | 0.0041 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0005 | 0.0006 | 0.0006 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2787 | 0.6495 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0005 | 0.0006 | 0.0006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | In vitro inhibitory activity against human erythrocyte Calpain 1 at a concentration of 50 uM | ChEMBL. | No reference |
Inhibition (binding) | < 10 % | In vitro inhibitory activity against human erythrocyte Calpain 1 at a concentration of 50 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.