Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.1262 | 0.9497 | 0.9007 |
Brugia malayi | RNA, U transporter 1 | 0.0072 | 0.0039 | 0.0039 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Echinococcus granulosus | hexokinase type 2 | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Leishmania major | hexokinase, putative | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Leishmania major | hexokinase, putative | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | casein kinase II | 0.0201 | 0.1062 | 0.1062 |
Echinococcus multilocularis | snurportin 1 | 0.0271 | 0.1618 | 0.1527 |
Echinococcus granulosus | geminin | 0.0149 | 0.065 | 0.0549 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Onchocerca volvulus | Hexokinase homolog | 0.0831 | 0.6075 | 0.6032 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Entamoeba histolytica | hexokinase 1 | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.1262 | 0.9497 | 0.9497 |
Loa Loa (eye worm) | hexokinase | 0.0831 | 0.6075 | 0.6075 |
Loa Loa (eye worm) | hexokinase | 0.041 | 0.2725 | 0.2725 |
Onchocerca volvulus | 0.0129 | 0.0491 | 0.0388 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1618 | 0.1618 |
Giardia lamblia | Kinase, CMGC CK2 | 0.1262 | 0.9497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0271 | 0.1618 | 0.1618 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Echinococcus multilocularis | hexokinase type 2 | 0.1325 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.065 | 0.065 |
Plasmodium vivax | hexokinase, putative | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0687 | 0.493 | 0.4876 |
Leishmania major | casein kinase II, putative | 0.1262 | 0.9497 | 0.9007 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Plasmodium falciparum | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.1262 | 0.9497 | 0.9491 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.1262 | 0.9497 | 0.9497 |
Trypanosoma brucei | Casein kinase II | 0.1262 | 0.9497 | 0.9007 |
Brugia malayi | Hexokinase family protein | 0.1325 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.065 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Brugia malayi | Peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.1262 | 0.9497 | 0.9007 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Brugia malayi | Blistered cuticle protein 3 | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2815 | 0.2815 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1262 | 0.9497 | 0.9437 |
Plasmodium vivax | unspecified product | 0.1262 | 0.9497 | 0.9007 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0247 | 0.0247 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0247 | 0.0247 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.1262 | 0.9497 | 0.9007 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Schistosoma mansoni | peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Entamoeba histolytica | casein kinase, putative | 0.1262 | 0.9497 | 0.9437 |
Trypanosoma cruzi | hexokinase, putative | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | Csnk2b protein | 0.0687 | 0.493 | 0.493 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.1325 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.1325 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Echinococcus multilocularis | geminin | 0.0149 | 0.065 | 0.0549 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Schistosoma mansoni | peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Treponema pallidum | hexokinase (hxk) | 0.1325 | 1 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0247 | 0.0247 |
Brugia malayi | Csnk2b protein | 0.0687 | 0.493 | 0.493 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0687 | 0.493 | 0.4876 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Echinococcus granulosus | snurportin 1 | 0.0271 | 0.1618 | 0.1527 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trypanosoma cruzi | casein kinase II, putative | 0.1262 | 0.9497 | 0.9007 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0687 | 0.493 | 0.4876 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Brugia malayi | hexokinase type II | 0.0421 | 0.2815 | 0.2815 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trypanosoma brucei | hexokinase | 0.1325 | 1 | 1 |
Giardia lamblia | Casein kinase II beta chain | 0.0687 | 0.493 | 0.4586 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0687 | 0.493 | 0.4876 |
Schistosoma mansoni | protein kinase | 0.1262 | 0.9497 | 0.9497 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0687 | 0.493 | 0.493 |
Brugia malayi | casein kinase II, putaitve | 0.0201 | 0.1062 | 0.1062 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.1262 | 0.9497 | 0.9491 |
Brugia malayi | Hexokinase family protein | 0.0831 | 0.6075 | 0.6075 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Onchocerca volvulus | 0.0831 | 0.6075 | 0.6032 | |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 0.6651 | 0.6651 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2815 | 0.2815 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Schistosoma mansoni | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.041 | 0.2725 | 0.2725 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1325 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trypanosoma brucei | hexokinase, putative | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trypanosoma cruzi | hexokinase, putative | 0.1325 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 200 uM | Cytotoxic concentration required to inhibit HEL cell growth by 50 % | ChEMBL. | 11212118 |
clogP | = 2 | Calculated partition coefficient (clogP) | ChEMBL. | 11212118 |
EC50 (functional) | = 0.06 uM | Effective concentration required for reduction of plaque formation of Varicella-Zoster Virus, (YS strain) | ChEMBL. | 11212118 |
EC50 (functional) | = 0.27 uM | Effective concentration required for reduction of plaque formation of Varicella-Zoster Virus (OKA strain) | ChEMBL. | 11212118 |
EC50 (functional) | > 50 uM | Effective concentration required for reduction of plaque formation of thymidine kinase deficient Varicella-Zoster Virus (YSR strain) | ChEMBL. | 11212118 |
EC50 (functional) | > 200 uM | Effective concentration required for reduction of plaque formation of thymidine kinase deficient Varicella-Zoster Virus (071 strain) | ChEMBL. | 11212118 |
MCC (functional) | > 200 uM | Minimum cytotoxic concentration required to alter microscopically detectable HEL cell morphology | ChEMBL. | 11212118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.