Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0024 | 0.2616 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0014 | 0.0021 | 0.0021 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.4705 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0024 | 0.2616 | 0.2616 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0033 | 0.4705 | 0.4705 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.4705 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0033 | 0.4705 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4265 | 0.4265 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2616 | 0.2616 |
Plasmodium vivax | JmjC domain containing protein | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0053 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0053 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.4705 | 0.4705 |
Schistosoma mansoni | intermediate filament proteins | 0.0024 | 0.2616 | 0.2616 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0014 | 0.0021 | 0.0021 |
Echinococcus multilocularis | GPCR, family 2 | 0.0014 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0045 | 0.7922 | 0.7922 |
Echinococcus multilocularis | lamin dm0 | 0.0024 | 0.2616 | 0.2616 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0021 | 0.0021 |
Echinococcus granulosus | lamin dm0 | 0.0024 | 0.2616 | 0.2616 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0024 | 0.2616 | 0.2616 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.4705 | 0.4705 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0014 | 0.0021 | 0.0021 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.4265 | 0.4265 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.4705 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.2616 | 0.5 | |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | intermediate filament protein | 0.0024 | 0.2616 | 0.2616 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.4265 | 0.4265 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0045 | 0.7922 | 0.7922 |
Echinococcus multilocularis | musashi | 0.0024 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0024 | 0.2616 | 0.2616 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0024 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0014 | 0.0021 | 0.0021 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0014 | 0.0021 | 0.0021 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0053 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0014 | 0.0021 | 0.0021 |
Echinococcus granulosus | lamin | 0.0024 | 0.2616 | 0.2616 |
Schistosoma mansoni | lamin | 0.0024 | 0.2616 | 0.2616 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0053 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0014 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0021 | 0.0021 |
Echinococcus multilocularis | lamin | 0.0024 | 0.2616 | 0.2616 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0014 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2502 | 0.2502 |
Brugia malayi | jmjC domain containing protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.7922 | 0.7922 |
Echinococcus granulosus | intermediate filament protein | 0.0024 | 0.2616 | 0.2616 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0033 | 0.4705 | 0.4705 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0045 | 0.7922 | 0.7922 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.4705 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dissociation constant | = 7.44 | Dissociation constant (pKa) | ChEMBL. | 6991693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.