Detailed information for compound 220927

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 260.245 | Formula: C13H12N2O4
  • H donors: 2 H acceptors: 3 LogP: 1.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1O)N=C[C@H]1N(C2=O)C(=CC1)O
  • InChi: 1S/C13H12N2O4/c1-19-11-4-8-9(5-10(11)16)14-6-7-2-3-12(17)15(7)13(8)18/h3-7,16-17H,2H2,1H3/t7-/m0/s1
  • InChiKey: YXQYOCBDDCSQEM-ZETCQYMHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.5115 0.5115
Brugia malayi ecdysteroid receptor 0.0039 0.5115 0.5115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.1274 0.0501
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0813 0.0813
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0813 0.159
Schistosoma mansoni nuclear receptor 0.0019 0.0813 0.0813
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Onchocerca volvulus Cathepsin L homolog 0.0022 0.1495 0.2923
Loa Loa (eye worm) fibroinase 0.0022 0.1495 0.1495
Brugia malayi nuclear receptor RXR 0.0021 0.1274 0.1274
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.5115 1
Brugia malayi steroid hormone receptor 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Schistosoma mansoni inositol monophosphatase 0.0037 0.4568 0.4568
Schistosoma mansoni thyroid hormone receptor 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.5115 0.5115
Entamoeba histolytica hypothetical protein 0.0036 0.4371 0.9569
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.5115 0.5115
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.1274 0.1274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0813 0.0813
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.1495 0.0742
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.1495 0.5
Echinococcus granulosus FTZ F1 alpha 0.0039 0.5115 0.5115
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.1495 0.1495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.5115 0.5115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0813 0.0813
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0813 0.0813
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0813 0.0813
Echinococcus multilocularis cysteine protease 0.0022 0.1495 0.0742
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.5115 0.5115
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.4568 1
Onchocerca volvulus 0.0022 0.1495 0.2923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0813 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.5115 0.5115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Onchocerca volvulus 0.0022 0.1495 0.2923
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.1495 0.3273
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.5115 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.4568 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.5115 0.5115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.5115 0.5115
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0813 0.0813
Brugia malayi conserved hypotetical protein 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.1495 0.1495
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0813 0.0813
Schistosoma mansoni hypothetical protein 0.0036 0.4371 0.4371
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.5115 0.5115
Brugia malayi nuclear receptor RXR 0.0019 0.0813 0.0813
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.1274 0.1274
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Onchocerca volvulus 0.0022 0.1495 0.2923
Brugia malayi nuclear receptor NHR-67 0.0019 0.0813 0.0813
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.5115 0.5115
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.1495 0.0742
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0813 0.0813
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.1274 0.1274
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.4568 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.5115 0.5115
Echinococcus granulosus cathepsin l1 0.0022 0.1495 0.1495
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.5115 0.4682
Brugia malayi Inositol-1 0.0037 0.4568 0.4568
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.4568 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.1495 0.1495
Loa Loa (eye worm) RNA binding protein 0.0063 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.1495 0.3273
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.4568 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.1495 0.3273
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.4568 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1495 0.3273
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.5115 0.5115
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.1495 0.5
Brugia malayi tailless protein 0.0019 0.0813 0.0813
Brugia malayi hypothetical protein 0.0036 0.4371 0.4371
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0813 0.0813
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.4568 0.5
Onchocerca volvulus 0.0022 0.1495 0.2923
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1495 0.3273
Schistosoma mansoni nuclear hormone receptor 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0021 0.1274 0.1274
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.4568 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.4371 0.4371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.5115 0.5115
Brugia malayi RNA recognition motif domain containing protein 0.0063 1 1
Loa Loa (eye worm) DR-78 0.0019 0.0813 0.0813
Schistosoma mansoni thyroid hormone receptor 0.0039 0.5115 0.5115
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0021 0.1274 0.1274
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.5115 0.4682
Onchocerca volvulus 0.0022 0.1495 0.2923
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0813 0.0813
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.4371 0.3873
Echinococcus granulosus tar DNA binding protein 0.0063 1 1
Brugia malayi nuclear hormone receptor 0.0019 0.0813 0.0813
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0813 0.0813
Onchocerca volvulus 0.0019 0.0813 0.159
Onchocerca volvulus 0.0019 0.0813 0.159
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Schistosoma mansoni nuclear receptor 0.0019 0.0813 0.0813
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0813 0.0813
Onchocerca volvulus 0.0039 0.5115 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.1495 0.0742
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Brugia malayi nuclear receptor NHR-88 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Onchocerca volvulus 0.0022 0.1495 0.2923
Brugia malayi hypothetical protein 0.0021 0.1274 0.1274
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.1495 0.1495
Brugia malayi TAR-binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Entamoeba histolytica cysteine protease, putative 0.0022 0.1495 0.3273
Loa Loa (eye worm) inositol-1 0.0037 0.4568 0.4568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Loa Loa (eye worm) ctsf protein 0.0022 0.1495 0.1495
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0021 0.1274 0.1274
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.1274 0.1274
Onchocerca volvulus Cathepsin F homolog 0.0022 0.1495 0.2923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Plasmodium vivax vivapain-2 0.0022 0.1495 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1495 0.3273
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Brugia malayi hypothetical protein 0.0021 0.1274 0.1274
Onchocerca volvulus 0.0022 0.1495 0.2923
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.5115 0.5115
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0813 0.0813
Schistosoma mansoni coup transcription factor 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0021 0.1274 0.1274
Plasmodium vivax vivapain-2 0.0022 0.1495 0.5
Brugia malayi hypothetical protein 0.0019 0.0813 0.0813
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.5115 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.4568 0.4568
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1495 0.3273
Loa Loa (eye worm) hypothetical protein 0.0039 0.5115 0.5115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0021 0.1274 0.1274
Entamoeba histolytica hypothetical protein 0.0036 0.4371 0.9569
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.1495 0.5
Brugia malayi nuclear hormone receptor 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.1495 0.3273
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.5115 0.5115
Entamoeba histolytica hypothetical protein 0.0036 0.4371 0.9569
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.4568 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.5115 0.4682
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0813 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.5115 0.5115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.5115 0.5115
Loa Loa (eye worm) cysteine protease 0.0022 0.1495 0.1495
Brugia malayi hypothetical protein 0.0019 0.0813 0.0813
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0813 0.159
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.4568 0.4568
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0813 0.0813
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.5115 0.4682
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.1495 0.3273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.5115 0.4682
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.1495 0.1495
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.3772 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.5115 0.4682
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.3772 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.4568 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.4568 0.4088
Onchocerca volvulus Cathepsin L homolog 0.0022 0.1495 0.2923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0813 0.0813
Schistosoma mansoni zinc finger protein 0.0019 0.0813 0.0813
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Echinococcus multilocularis tar DNA binding protein 0.0063 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0813 0.0813
Entamoeba histolytica hypothetical protein 0.0036 0.4371 0.9569
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.5115 0.5115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.5115 0.4682
Brugia malayi ecdysone receptor 0.0019 0.0813 0.0813
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.4568 1
Loa Loa (eye worm) TAR-binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1495 0.1495
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.5115 0.4682
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.5115 0.4682
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.5115 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1495 0.3273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.5115 0.5115
Brugia malayi Cathepsin L-like precursor 0.0022 0.1495 0.1495
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.5115 0.5115
Echinococcus multilocularis cysteine protease 0.0022 0.1495 0.0742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.5115 0.5115
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.1274 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.5115 0.5115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.5115 0.5115
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.1495 0.0742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1495 0.3273
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.5115 0.5115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0019 0.0813 0.0813
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.4371 0.4371
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.5115 0.5115

Activities

Activity type Activity value Assay description Source Reference
Max T/C (functional) = 111 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
Max T/C (functional) = 122 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
Max T/C (functional) = 128 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
Max T/C (functional) = 133 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
Max T/C (functional) = 138 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
Max T/C (functional) = 150 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 2 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 2 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 3 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 3 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 4 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 4 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 8 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 8 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 16 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905
OD (functional) = 16 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia at a dose schedule of qd1-5 ChEMBL. 3973905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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