Detailed information for compound 22095

Basic information

Technical information
  • TDR Targets ID: 22095
  • Name: 5-(2-chloroethyl)-1-[3,4-dihydroxy-5-(hydroxy methyl)oxolan-2-yl]pyrimidine-2,4-dione
  • MW: 306.7 | Formula: C11H15ClN2O6
  • H donors: 4 H acceptors: 5 LogP: -1.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCc1cn(c(=O)[nH]c1=O)C1OC(C(C1O)O)CO
  • InChi: 1S/C11H15ClN2O6/c12-2-1-5-3-14(11(19)13-9(5)18)10-8(17)7(16)6(4-15)20-10/h3,6-8,10,15-17H,1-2,4H2,(H,13,18,19)
  • InChiKey: VSWBKXJDWJNKJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2-chloroethyl)-1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 5-(2-chloroethyl)-1-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 5-(2-chloroethyl)-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0083 0.0746 0.0847
Echinococcus granulosus programmed cell death protein 4 0.006 0.0449 0.0392
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.01 0.005
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0083 0.0746 0.0746
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0645 0.0589
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.01 0.01
Leishmania major adenosine kinase, putative 0.0261 0.3063 0.3063
Plasmodium vivax FACT complex subunit SPT16, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.01 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.01 0.01
Giardia lamblia Xaa-Pro dipeptidase 0.0083 0.0746 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0795 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0654 0.8166 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.018 0.2072
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Giardia lamblia Xaa-Pro dipeptidase 0.0083 0.0746 1
Echinococcus granulosus xaa Pro dipeptidase 0.0083 0.0746 0.0691
Mycobacterium ulcerans dipeptidase 0.0083 0.0746 0.0847
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.01 0.005
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0083 0.0746 0.0847
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Schistosoma mansoni hypothetical protein 0.0352 0.425 0.5169
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0083 0.0746 0.0746
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0083 0.0746 0.0691
Leishmania major hypothetical protein, conserved 0.0083 0.0746 0.0746
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0059 0.0059
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Schistosoma mansoni chromobox protein 0.007 0.0577 0.0638
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.2618 0.2618
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.018
Echinococcus granulosus xaa pro aminopeptidase 0.0083 0.0746 0.0691
Echinococcus granulosus adenosine kinase 0.0261 0.3063 0.3022
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0099 0.0959 0.3438
Trichomonas vaginalis chromobox protein, putative 0.007 0.0577 0.7634
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis xaa Pro dipeptidase 0.0083 0.0746 0.0691
Entamoeba histolytica hypothetical protein, conserved 0.0083 0.0746 0.7628
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Entamoeba histolytica aminopeptidase, putative 0.0083 0.0746 0.7628
Schistosoma mansoni hypothetical protein 0.0352 0.425 0.5169
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0218 0.0607
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.01 0.01
Toxoplasma gondii methionine aminopeptidase 0.0795 1 1
Echinococcus multilocularis methionine aminopeptidase, type I 0.0083 0.0746 0.0691
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Brugia malayi initiation factor 2-associated protein. 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0083 0.0746 0.0746
Trypanosoma brucei ribokinase, putative 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0099 0.0959 0.0959
Brugia malayi photoreceptor-specific nuclear receptor 0.0276 0.3259 0.3259
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.032 0.032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.032 0.032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Toxoplasma gondii peptidase D, putative 0.0083 0.0746 0.0746
Giardia lamblia Methionine aminopeptidase 0.0083 0.0746 1
Plasmodium vivax peptidase, putative 0.0083 0.0746 0.0746
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0654 0.8166 0.8166
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0795 1 1
Chlamydia trachomatis methionine aminopeptidase 0.0654 0.8166 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Trypanosoma brucei adenosine kinase, putative 0.0261 0.3063 0.3063
Onchocerca volvulus 0.0031 0.007 0.0042
Brugia malayi chromobox protein homolog 3 0.0039 0.018 0.018
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Trypanosoma cruzi ribokinase, putative 0.003 0.0059 0.0059
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.006 0.0449 0.0449
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.018 0.2072
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Onchocerca volvulus 0.0231 0.2677 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Trypanosoma brucei ribokinase, putative 0.003 0.0059 0.0059
Echinococcus granulosus xaa Pro dipeptidase 0.0083 0.0746 0.0691
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0577 0.0577
Echinococcus multilocularis adenosine kinase 0.0261 0.3063 0.3022
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0083 0.0746 0.2623
Echinococcus multilocularis programmed cell death protein 4 0.006 0.0449 0.0392
Schistosoma mansoni peptidase 0.0083 0.0746 0.0847
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0059 0.0059
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.01 0.01
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0795 1 1
Trypanosoma brucei adenosine kinase, putative 0.0261 0.3063 0.3063
Echinococcus multilocularis Proliferation associated protein 2G4 0.0083 0.0746 0.0691
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0795 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Mycobacterium ulcerans methionine aminopeptidase 0.0654 0.8166 1
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Trypanosoma cruzi aminopeptidase P, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0083 0.0746 0.0691
Toxoplasma gondii kinase, pfkB family protein 0.0261 0.3063 0.3063
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0083 0.0746 0.0847
Echinococcus granulosus Proliferation associated protein 2G4 0.0083 0.0746 0.0691
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Treponema pallidum methionine aminopeptidase (map) 0.0654 0.8166 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus granulosus chromobox protein 1 0.007 0.0577 0.0521
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Toxoplasma gondii MA3 domain-containing protein 0.006 0.0449 0.0449
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0083 0.0746 0.0847
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Schistosoma mansoni hypothetical protein 0.0034 0.0115 0.0069
Mycobacterium tuberculosis Dipeptidase PepE 0.0083 0.0746 0.0847
Plasmodium vivax hypothetical protein, conserved 0.006 0.0449 0.0449
Echinococcus granulosus methionine aminopeptidase type I 0.0083 0.0746 0.0691
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0654 0.8166 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0795 1 1
Schistosoma mansoni chromobox protein 0.007 0.0577 0.0638
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.01 0.01
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0083 0.0746 0.0847
Brugia malayi hypothetical protein 0.003 0.0059 0.0059
Echinococcus granulosus methionyl aminopeptidase 2 0.0083 0.0746 0.0691
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Schistosoma mansoni hypothetical protein 0.0075 0.0645 0.0722
Loa Loa (eye worm) hypothetical protein 0.0034 0.0115 0.0115
Brugia malayi Isocitrate dehydrogenase 0.0033 0.01 0.01
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0795 1 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0654 0.8166 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.01 0.01
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.01 0.0041
Toxoplasma gondii creatinase domain-containing protein 0.0083 0.0746 0.0746
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0645 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0059 0.0386
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0115 0.0115
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Echinococcus multilocularis xaa Pro dipeptidase 0.0083 0.0746 0.0691
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Plasmodium falciparum aminopeptidase P 0.0083 0.0746 0.0746
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0083 0.0746 0.0746
Brugia malayi Ribokinase 0.003 0.0059 0.0059
Leishmania major putative PfkB family sugar kinase 0.003 0.0059 0.0059
Plasmodium vivax methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis FACT complex subunit SPT16 0.0083 0.0746 0.0691
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Echinococcus granulosus geminin 0.0352 0.425 0.4215
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.018 0.046
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Onchocerca volvulus Dipeptidase C homolog 0.0083 0.0746 0.2623
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Toxoplasma gondii kinase, pfkB family protein 0.003 0.0059 0.0059
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.005 0.032 0.032
Brugia malayi isocitrate dehydrogenase 0.0033 0.01 0.01
Leishmania major transcription factor-like protein 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus multilocularis xaa pro aminopeptidase 0.0083 0.0746 0.0691
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0654 0.8166 0.8166
Brugia malayi Heterochromatin protein 1 0.007 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0261 0.3063 0.3063
Loa Loa (eye worm) DNA-binding protein 0.0083 0.0746 0.0746
Echinococcus multilocularis chromobox protein 1 0.007 0.0577 0.0521
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.2897 0.2897
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0654 0.8166 1
Leishmania major methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.032 0.032
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0083 0.0746 0.0847
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.2897 0.2897
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Leishmania major ribokinase, putative 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0645 0.0589
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Trypanosoma cruzi aminopeptidase P1, putative 0.0083 0.0746 0.0746
Schistosoma mansoni adenosine kinase 0.0261 0.3063 0.3705
Brugia malayi follicle stimulating hormone receptor 0.0227 0.2618 0.2618
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0059 0.0059
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Schistosoma mansoni programmed cell death protein 0.006 0.0449 0.0481
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0083 0.0746 0.0847
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.0141 0.1507 0.1507
Trichomonas vaginalis chromobox protein, putative 0.007 0.0577 0.7634
Schistosoma mansoni programmed cell death protein 0.006 0.0449 0.0481
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.1507 0.1507
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0083 0.0746 0.7628
Leishmania major adenosine kinase-like protein 0.003 0.0059 0.0059
Mycobacterium ulcerans dipeptidase PepE 0.0083 0.0746 0.0847
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Brugia malayi hypothetical protein 0.0075 0.0645 0.0645
Trypanosoma brucei Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Plasmodium falciparum methionine aminopeptidase 2 0.0083 0.0746 0.0746
Brugia malayi MH2 domain containing protein 0.0248 0.2897 0.2897
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.3259 0.3259
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0083 0.0746 0.0746
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 0.8155
Trypanosoma brucei hypothetical protein, conserved 0.0141 0.1507 0.1507
Loa Loa (eye worm) methionine aminopeptidase type I 0.0795 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0083 0.0746 0.0746
Mycobacterium ulcerans aminopeptidase 0.0083 0.0746 0.0847
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0083 0.0746 0.0691
Toxoplasma gondii methionine aminopeptidase 0.0654 0.8166 0.8166
Toxoplasma gondii transcriptional elongation factor FACT140 0.0083 0.0746 0.0746
Echinococcus granulosus chromobox protein 1 0.007 0.0577 0.0521
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0059
Echinococcus multilocularis chromobox protein 1 0.007 0.0577 0.0521
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.3063 0.3063
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.01 0.01
Toxoplasma gondii hypothetical protein 0.0141 0.1507 0.1507
Echinococcus granulosus FACT complex subunit SPT16 0.0083 0.0746 0.0691
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Leishmania major adenosine kinase-like protein 0.003 0.0059 0.0059
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0218 0.261
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0218 0.261
Entamoeba histolytica methionine aminopeptidase, putative 0.0083 0.0746 0.7628
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0083 0.0746 0.0746
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0083 0.0746 0.0746
Plasmodium falciparum HP12 protein homolog, putative 0.0141 0.1507 0.1507
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0654 0.8166 1
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0083 0.0746 0.2623
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Loa Loa (eye worm) initiation factor 2-associated protein 0.0083 0.0746 0.0746
Brugia malayi HSF-type DNA-binding domain containing protein 0.0099 0.0959 0.0959
Entamoeba histolytica peptidase, putative 0.0083 0.0746 0.7628
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.1507 0.1507
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0795 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0654 0.8166 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0654 0.8166 0.8166
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 1
Onchocerca volvulus 0.0083 0.0746 0.2623
Plasmodium vivax hypothetical protein, conserved 0.0141 0.1507 0.1507
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Brugia malayi Adenosine kinase-like 0.0261 0.3063 0.3063
Echinococcus multilocularis geminin 0.0352 0.425 0.4215
Schistosoma mansoni adenosine kinase 0.0261 0.3063 0.3705
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 1
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.3063 0.3063
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0059 0.0059

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 30 ug ml-1 Antiviral activity against HSV-1 (Brand) in Vero cells ChEMBL. 3037079
MIC (functional) = 30 ug ml-1 Antiviral activity against HSV-1 (Brand) in human epithelial (Hep-2) cells ChEMBL. 3037079
MIC (functional) = 100 ug ml-1 Antiviral activity against HSV-2 (K979) in Vero cells ChEMBL. 3037079
MIC (functional) = 100 ug ml-1 Antiviral activity against HSV-2 (K979) in human epithelial (Hep-2) cells ChEMBL. 3037079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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