TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 328.45 | Formula: C23H24N2
H donors: 0 H acceptors: 0 LogP: 4.38 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cn1c2CCN(Cc2c2c1cccc2)CC#CCCc1ccccc1
InChi: 1S/C23H24N2/c1-24-22-14-8-7-13-20(22)21-18-25(17-15-23(21)24)16-9-3-6-12-19-10-4-2-5-11-19/h2,4-5,7-8,10-11,13-14H,6,12,15-18H2,1H3
InChiKey: SUDXGXXSLCIRIO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	Starlite/ChEMBL	References
Mus musculus	5-hydroxytryptamine (serotonin) receptor 5A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0053	0.0068
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0029	0.0024
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0029	0.0033
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0052	0.0067
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0965	0.2358	0.2343
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0005	0.0005
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0053	0.0441
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0035	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0052	0.0047
Echinococcus granulosus	thymidylate synthase	0.0965	0.2358	0.2354
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0029	0.0024
Schistosoma mansoni	dihydrofolate reductase	0.4046	1	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0065	0.0084
Leishmania major	glucose transporter, lmgt2	0.0036	0.0053	0.0068
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0053	0.0441
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0006	0.0002
Plasmodium falciparum	protein kinase 6	0.0489	0.1178	0.1653
Trichomonas vaginalis	conserved hypothetical protein	0.0459	0.1103	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0052	0.0067
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0006	0.0001
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0006	0.0001
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0006	0.0002
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.2878	0.7103	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0053	0.0068
Loa Loa (eye worm)	sugar transporter	0.0016	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Schistosoma mansoni	protein kinase	0.0035	0.0052	0.0047
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0029	0.0024
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0053	0.0068
Brugia malayi	thymidylate synthase	0.0965	0.2358	0.2354
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0006	0.0002
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Echinococcus multilocularis	General substrate transporter	0.0099	0.0211	0.0206
Schistosoma mansoni	protein kinase	0.0035	0.0052	0.0047
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0052	0.0047
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0006	0.0002
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0065	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0034	0.0034
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Echinococcus multilocularis	geminin	0.018	0.041	0.0406
Trypanosoma brucei	glucose transporter 1E	0.0036	0.0053	0.0068
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.2878	0.7103	1
Echinococcus granulosus	dihydrofolate reductase	0.4046	1	1
Brugia malayi	Dihydrofolate reductase	0.4046	1	1
Entamoeba histolytica	protein kinase, putative	0.0035	0.0052	0.8441
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0006	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0052	0.0052
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.4046	1	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0029	0.0033
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0053	0.0068
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0006	0.0001
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0021	0.0143
Toxoplasma gondii	protein kinase, putative	0.0326	0.0773	0.1082
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0053	0.0068
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0052	0.0067
Entamoeba histolytica	protein kinase, putative	0.0035	0.0052	0.8441
Brugia malayi	beta-NAC-like protein	0.0037	0.0057	0.0052
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0029	0.001
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0186	0.0427	0.0594
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0065	0.0084
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0019	0.0014
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0052	0.0067
Plasmodium vivax	hexose transporter	0.0115	0.0251	0.0346
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0052	0.0067
Leishmania major	protein kinase, putative	0.0035	0.0052	0.0067
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.2878	0.7103	1
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0057	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.0251	0.2237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Giardia lamblia	Prolyl-tRNA synthetase	0.0035	0.0051	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0029	0.0024
Echinococcus multilocularis	dihydrofolate reductase	0.4046	1	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0029	0.0033
Mycobacterium ulcerans	thymidylate synthase	0.0965	0.2358	0.2354
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0057	0.0052
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0006	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.2878	0.7103	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0006	0.0001
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0035	0.0051	0.0415
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0047	0.0042
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0065	0.0084
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0115	0.0251	0.0246
Trypanosoma brucei	glucose transporter 2A	0.0036	0.0053	0.0068
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0057	0.0471
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0186	0.0427	0.0594
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0052	0.0067
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0057	0.0073
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0057	0.0471
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0006	0.0001
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0052	0.0047
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0052	0.0067
Echinococcus granulosus	General substrate transporter	0.0099	0.0211	0.0206
Entamoeba histolytica	hypothetical protein	0.0037	0.0057	1
Loa Loa (eye worm)	thymidylate synthase	0.0965	0.2358	0.2358
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0047	0.0042
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0019	0.0014
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0065	0.0084
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0053	0.0441
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0489	0.1178	0.1653
Loa Loa (eye worm)	sugar transporter	0.0115	0.0251	0.0251
Schistosoma mansoni	hypothetical protein	0.0115	0.0251	0.0246
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0052	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0053	0.0441
Loa Loa (eye worm)	dihydrofolate reductase	0.4046	1	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0035	0.0051	0.7811
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0029	0.0033
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0057	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0459	0.1103	0.1547
Brugia malayi	hypothetical protein	0.0459	0.1103	0.1099
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0029	0.0033
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0186	0.0427	0.0594
Brugia malayi	Cam kinase protein 1	0.0035	0.0052	0.0047
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0965	0.2358	0.2354
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0006	0.0001
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0029	0.0024
Schistosoma mansoni	glucose transport protein	0.0115	0.0251	0.0246
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0057	0.0073
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0052	0.0067
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0029	0.0215
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0057	0.0073
Onchocerca volvulus		0.0965	0.2358	1
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0053	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0005	0.0005
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0029	0.0024
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0052	0.0067
Schistosoma mansoni	hypothetical protein	0.018	0.041	0.0406
Schistosoma mansoni	glucose transport protein	0.0115	0.0251	0.0246
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0006	0.0002
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0051	0.0046
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0053	0.0068
Brugia malayi	Sugar transporter family protein	0.0115	0.0251	0.0246
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0035	0.0051	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0053	0.0441
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0053	0.0068
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Schistosoma mansoni	protein kinase	0.0035	0.0052	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.4046	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.2878	0.7103	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0006	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0052	0.0067
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0035	0.0051	0.0046
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0065	0.0084
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0029	0.5182
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0053	0.0441
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0006	0.0001
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0965	0.2358	0.2354
Leishmania major	glucose transporter, lmgt3	0.0036	0.0053	0.0068
Mycobacterium tuberculosis	Hypothetical protein	0.0459	0.1103	0.1099
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Leishmania major	glucose transporter, lmgt1	0.0036	0.0053	0.0068
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0065	0.0084
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0057	0.0073
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0052	0.0067
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0036	0.0053	0.0068
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0052	0.0067
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0052	0.0431
Schistosoma mansoni	glucose transport protein	0.0115	0.0251	0.0246
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0057	0.0073
Toxoplasma gondii	facilitative glucose transporter GT1	0.0115	0.0251	0.0346
Plasmodium falciparum	hexose transporter	0.0115	0.0251	0.0346
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0006	0.0001
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0065	0.0084
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0115	0.0251	0.0246
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0051	0.0046
Echinococcus granulosus	geminin	0.018	0.041	0.0406
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.2878	0.7103	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0006	0.0002
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0051	0.0051
Trypanosoma cruzi	hexose transporter	0.0036	0.0053	0.0068
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0029	0.0033
Echinococcus multilocularis	thymidylate synthase	0.0965	0.2358	0.2354
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0057	0.0471
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0029	0.0024
Plasmodium falciparum	protein kinase 7	0.0326	0.0773	0.1082
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0057	0.0073
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0006	0.0002
Schistosoma mansoni	hypothetical protein	0.018	0.041	0.0406
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0051	0.0046
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0006	0.0002
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0052	0.0067
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0006	0.0006
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0013	0.0012
Chlamydia trachomatis	dihydrofolate reductase	0.4046	1	1
Schistosoma mansoni	transcription factor btf3	0.0037	0.0057	0.0052
Echinococcus granulosus	transcription factor btf3	0.0037	0.0057	0.0052
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0052	0.0047
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.4046	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1710 nM	Binding affinity towards mouse 5-hydroxytryptamine 5A receptor using LSD as radioligand	ChEMBL.	12930153
Ki (binding)	= 1710 nM	Binding affinity towards mouse 5-hydroxytryptamine 5A receptor using LSD as radioligand	ChEMBL.	12930153
Ki (binding)	= 1775 nM	Binding affinity towards human 5-hydroxytryptamine 5A receptor using LSD as radioligand	ChEMBL.	12930153
Ki (binding)	= 1775 nM	Binding affinity towards human 5-hydroxytryptamine 5A receptor using LSD as radioligand	ChEMBL.	12930153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL129774

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 221061