Detailed information for compound 2211449

Basic information

Technical information
  • TDR Targets ID: 2211449
  • Name: [(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1R, 2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3- diamino-3-oxopropyl]amino]-3-oxopropyl]-5-met hylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S )-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-oxo-1-[2- [4-[4-[3-[[(1S)-1-phenylethyl]amino]propylcar bamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]et hylamino]butan-2-yl]amino]-4-methyl-5-oxopent an-2-yl]amino]-1-(3H-imidazol-4-yl)-3-oxoprop oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl ]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl ] carbamate
  • MW: 1472.58 | Formula: C61H88N18O21S2
  • H donors: 21 H acceptors: 21 LogP: -6.68 Rotable bonds: 43
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H]1O[C@@H](O[C@H]([C@@H](C(=O)N[C@@H]([C@H]([C@@H](C(=O)N[C@H](C(=O)NCCc2scc(n2)c2scc(n2)C(=O)NCCCN[C@H](c2ccccc2)C)[C@H](O)C)C)O)C)NC(=O)c2nc(nc(c2C)N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)c2nc[nH]c2)[C@H]([C@H]([C@@H]1O)O)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@@H]1O)OC(=O)N)O
  • InChi: InChI=1S/C61H88N18O21S2/c1-24-39(76-52(79-50(24)64)31(16-37(63)83)71-17-30(62)51(65)89)56(93)78-41(47(32-18-67-23-72-32)98-60-49(45(87)43(85)35(19-80)97-60)99-59-46(88)48(100-61(66)95)44(86)36(20-81)96-59)57(94)73-27(4)42(84)25(2)53(90)77-40(28(5)82)55(92)70-15-12-38-74-34(22-101-38)58-75-33(21-102-58)54(91)69-14-9-13-68-26(3)29-10-7-6-8-11-29/h6-8,10-11,18,21-23,25-28,30-31,35-36,40-49,59-60,68,71,80-82,84-88H,9,12-17,19-20,62H2,1-5H3,(H2,63,83)(H2,65,89)(H2,66,95)(H,67,72)(H,69,91)(H,70,92)(H,73,94)(H,77,90)(H,78,93)(H2,64,76,79)/t25-,26-,27+,28+,30-,31-,35-,36+,40-,41-,42-,43+,44+,45-,46-,47-,48-,49-,59+,60-/m0/s1
  • InChiKey: QIMGFXOHTOXMQP-GFAGFCTOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxo-propyl]amino]-3-oxo-propyl]-5-methyl-pyrimidin-4-yl]carbonylamino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-oxo-1-[2-[4-[4-[3-[[(1S)-1-phenylethyl]amino]propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]butan-2-yl]amino]-4-methyl-5-oxo-pentan-2-yl]amino]-1-(3H-imidazol-4-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate
  • NK-631

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0042 0.005
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.1026 0.1064
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0264 0.1197 0.3238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0358 0.097
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0136 0.0141
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0059 0.0059
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0743 0.3696 0.3696
Onchocerca volvulus 0.0147 0.0583 0.4011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0136 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.0404
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0068 0.0174 0.0183
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0264 0.1197 0.3238
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0847 0.0847
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0147 0.0583 0.1579
Echinococcus multilocularis GPCR, family 2 0.0063 0.0145 0.0145
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0136 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0068 0.0174 0.0174
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0068 0.0174 0.018
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0743 0.3696 0.4436
Brugia malayi thymidylate synthase 0.0314 0.1454 0.1508
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0136 0.0136
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0068 0.0174 0.0242
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0032 0.0032
Mycobacterium ulcerans thymidylate synthase 0.0314 0.1454 0.3935
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.039 0.1054
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0068 0.0174 0.0174
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0264 0.1197 0.3238
Echinococcus granulosus carbonic anhydrase 0.0769 0.3834 0.3834
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.0404
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0136 0.0136
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0136 0.0136
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0043 0.0042 0.0114
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0264 0.1197 0.3238
Schistosoma mansoni carbonic anhydrase 0.0769 0.3834 0.3834
Plasmodium falciparum acyl-CoA synthetase 0.011 0.039 0.0524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.1252 0.1252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0136 0.0141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0145 0.015
Toxoplasma gondii hypothetical protein 0.0057 0.0116 0.0116
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0068 0.0174 0.0183
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Schistosoma mansoni aspartate carbamoyltransferase 0.0168 0.0694 0.0694
Schistosoma mansoni carbonic anhydrase-related 0.0769 0.3834 0.3834
Echinococcus granulosus geminin 0.0165 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.0404
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0068 0.0174 0.0174
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0149 0.0596 0.0715
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0583 0.1579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0136 0.0141
Schistosoma mansoni carbonic anhydrase-related 0.0769 0.3834 0.3834
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0136 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0356 0.0427
Schistosoma mansoni patched 1 0.0085 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0166 0.0684 0.0684
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0042 0.0114
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0068 0.0174 0.0174
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0136 0.0136
Echinococcus granulosus expressed conserved protein 0.0185 0.0784 0.0784
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0583 0.0605
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0744 0.3701 0.3701
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0333 0.1554 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0136 0.0934
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0356 0.0476
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0147 0.0583 0.0605
Echinococcus multilocularis muscleblind protein 0.1543 0.7873 0.7873
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0108 0.0131
Onchocerca volvulus 0.0061 0.0136 0.0934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.1252 0.1252
Echinococcus granulosus peptidase Clp S14 family 0.0109 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0063 0.0145 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.1252 0.1252
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0136 0.0136
Toxoplasma gondii exonuclease III APE 0.0056 0.0108 0.0108
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0743 0.3696 0.3696
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0042 0.0114
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0743 0.3696 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0168 0.0694 0.0694
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0068 0.0174 0.0222
Loa Loa (eye worm) hypothetical protein 0.0104 0.0358 0.0372
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0769 0.3834 0.3976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0136 0.0141
Trypanosoma brucei carbonic anhydrase-like protein 0.163 0.8331 0.8331
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0068 0.0174 0.0174
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.1614
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0068 0.0174 0.0174
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0743 0.3696 1
Brugia malayi CHE-14 protein 0.0085 0.0259 0.0268
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0847 0.541
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0264 0.1197 0.1437
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0042 0.0114
Entamoeba histolytica acyl-coA synthetase, putative 0.0147 0.0583 0.3699
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0032 0.0115
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.163 0.8331 0.8331
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.195 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.0583 0.3699
Plasmodium falciparum carbonic anhydrase 0.0769 0.3834 0.5326
Leishmania major carbonic anhydrase-like protein 0.163 0.8331 0.8331
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0168 0.0694 0.0833
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0136 0.0141
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0548 0.0568
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0059 0.0059
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0068 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0068 0.0174 0.047
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0068 0.0174 0.047
Schistosoma mansoni hypothetical protein 0.0165 0.0679 0.0679
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0042 0.0042
Schistosoma mansoni ap endonuclease 0.0056 0.0108 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0854 0.0885
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0068 0.0174 0.047
Brugia malayi hypothetical protein 0.0149 0.0596 0.0618
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0168 0.0694 0.1877
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0168 0.0694 0.0694
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0145 0.015
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.1454
Brugia malayi Carboxyl transferase domain containing protein 0.1882 0.9643 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0068 0.0174 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Onchocerca volvulus 0.0043 0.0042 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0583 0.1579
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0068 0.0174 0.018
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.163 0.8331 0.8639
Echinococcus multilocularis carbonic anhydrase 0.0769 0.3834 0.3834
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0769 0.3834 0.3976
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.0404
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0743 0.3696 1
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0136 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0136 0.0136
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.1746
Schistosoma mansoni glutaminase 0.0567 0.2778 0.2778
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.0404
Brugia malayi nuclear receptor NHR-88 0.0061 0.0136 0.0141
Leishmania major hypothetical protein, conserved 0.0103 0.0356 0.0356
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0743 0.3696 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0166 0.0684 0.0684
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0108 0.0112
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0744 0.3701 0.3701
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0068 0.0174 0.0174
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0032 0.0032
Trichomonas vaginalis glutaminase, putative 0.0567 0.2778 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0042 0.0114
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0108 0.0129
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0264 0.1197 0.1197
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0356 0.0476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0108 0.0129
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0264 0.1197 0.1197
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0136 0.0141
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0068 0.0174 0.0174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0108 0.0292
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.0583 0.1579
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0136 0.0141
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.1289 0.1289
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0264 0.1197 0.1197
Brugia malayi hypothetical protein 0.0067 0.0165 0.0171
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0548 0.0548
Loa Loa (eye worm) thymidylate synthase 0.0314 0.1454 0.1508
Brugia malayi MH2 domain containing protein 0.0232 0.1026 0.1064
Echinococcus multilocularis carbonic anhydrase II 0.163 0.8331 0.8331
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0136 0.0136
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0109 0.0386 0.1043
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0136 0.0136
Loa Loa (eye worm) glutaminase 2 0.0567 0.2778 0.2881
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0068 0.0174 0.0174
Brugia malayi hypothetical protein 0.0152 0.0609 0.0632
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0854 0.0885
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0042 0.0044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.0583 0.1579
Schistosoma mansoni hypothetical protein 0.0769 0.3834 0.3834
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0743 0.3696 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0136 0.0141
Trypanosoma brucei acetyl-CoA carboxylase 0.195 1 1
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0743 0.3696 1
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0526 0.0545
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0583 0.0583
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0314 0.1454 0.3935
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0042 0.0114
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0136 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0136 0.0136
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0136 0.0136
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0042 0.005
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0042 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0108 0.0388
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0108 0.0388
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0743 0.3696 0.3696
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0145 0.0145
Onchocerca volvulus 0.0043 0.0042 0.0289
Loa Loa (eye worm) hypothetical protein 0.0769 0.3834 0.3976
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0068 0.0174 0.047
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0057 0.0116 0.0313
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0068 0.0174 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.1252 0.1252
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0042 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Echinococcus granulosus muscleblind protein 0.1543 0.7873 0.7873
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0068 0.0174 0.0174
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0264 0.1197 0.3238
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.163 0.8331 0.8331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0583 0.0605
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0264 0.1197 0.3238
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0108 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0259 0.0259
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0068 0.0174 0.0208
Toxoplasma gondii carbamoylphosphate synthetase 0.0168 0.0694 0.0694
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.011 0.039 0.1054
Loa Loa (eye worm) hypothetical protein 0.0063 0.0145 0.015
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0068 0.0174 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0583 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0136 0.0141
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0136 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0136 0.0136
Brugia malayi Muscleblind-like protein 0.1543 0.7873 0.8164
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0042 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0136 0.0136
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.011 0.039 0.0683
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0032 0.0044
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0264 0.1197 0.1437
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0136 0.0141
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0743 0.3696 0.3696
Mycobacterium ulcerans hypothetical protein 0.0068 0.0174 0.047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0136 0.0136
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0743 0.3696 0.4436
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0042 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0356 0.0427
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0275 0.1252 0.1298
Loa Loa (eye worm) hypothetical protein 0.0166 0.0684 0.071
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0068 0.0174 0.0242
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0042 0.0114
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0042 0.0114
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0264 0.1197 0.3238
Echinococcus multilocularis carbonic anhydrase 0.0769 0.3834 0.3834
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0042 0.0182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 1
Schistosoma mansoni hypothetical protein 0.0136 0.0526 0.0526
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0068 0.0174 0.0174
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0043 0.0042 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0152 0.0609 0.0632
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1411 0.7186 1
Echinococcus multilocularis protein patched 0.0085 0.0259 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0136 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0042 0.0114
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.1852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0136 0.0141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0136 0.0136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0145 0.0145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0358 0.097
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.195 1 1
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0264 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0103 0.0356 0.0369
Loa Loa (eye worm) hypothetical protein 0.0147 0.0583 0.0605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0358 0.097
Echinococcus granulosus Biotin lipoyl attachment 0.0068 0.0174 0.0174
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.163 0.8331 0.8639
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0068 0.0174 0.0222
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0264 0.1197 0.1437
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0042 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.1252 0.1252
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0068 0.0174 0.0208
Onchocerca volvulus 0.0152 0.0609 0.4188
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0068 0.0174 0.018
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0356 0.0356
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0042 0.005
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0042 0.0044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0987 0.267
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0109 0.0386 0.1043
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0147 0.0583 0.1579
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0068 0.0174 0.0174
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0136 0.0934
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0264 0.1197 0.3035
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0769 0.3834 0.3976
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Schistosoma mansoni hypothetical protein 0.0046 0.0059 0.0059
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0264 0.1197 0.3238
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0042 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.1252 0.1252
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0147 0.0583 0.1579
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.163 0.8331 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0136 0.0136
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0116 0.0138
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0042 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0042 0.0114
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0068 0.0174 0.0174
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0168 0.0694 0.0965
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0847 0.0847
Onchocerca volvulus 0.0043 0.0042 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0259 0.0932
Loa Loa (eye worm) hypothetical protein 0.0068 0.0174 0.018
Onchocerca volvulus 0.0314 0.1454 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.1454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0275 0.1252 0.1298
Treponema pallidum pyruvate carboxylase subunit B 0.0068 0.0174 0.114
Schistosoma mansoni ap endonuclease 0.0056 0.0108 0.0108
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0042 0.0042
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0108 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0596 0.2145
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0068 0.0174 0.0208
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0136 0.0136
Echinococcus multilocularis Biotin lipoyl attachment 0.0068 0.0174 0.0174
Brugia malayi Putative carbonic anhydrase 5 precursor 0.163 0.8331 0.8639
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0769 0.3834 0.3976
Mycobacterium ulcerans hypothetical protein 0.0147 0.0583 0.1579
Chlamydia trachomatis biotin carboxylase 0.0675 0.3339 1
Schistosoma mansoni acetyl-CoA carboxylase 0.195 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0526 0.0545
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0863 0.0863
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0583 0.1579
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0042 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.1543 0.7873 0.8164
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0042 0.0151
Plasmodium vivax acyl-CoA synthetase, putative 0.011 0.039 0.0542
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0168 0.0694 0.0694
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0108 0.0108
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1411 0.7186 1
Loa Loa (eye worm) oxidoreductase 0.0043 0.0042 0.0044
Loa Loa (eye worm) carbonic anhydrase 3 0.163 0.8331 0.8639
Plasmodium falciparum carbamoyl phosphate synthetase 0.0168 0.0694 0.0948
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.0583 0.3699
Mycobacterium ulcerans glutaminase 0.0567 0.2778 0.7516
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.1454
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0042 0.0042
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0042 0.0114
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0063 0.0145 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0264 0.1197 0.3238
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0166 0.0684 0.0952
Leishmania major acetyl-CoA carboxylase, putative 0.195 1 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0743 0.3696 1
Brugia malayi Probable ClpP-like protease 0.0166 0.0684 0.071
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0042 0.0044
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.1852
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0136 0.0136
Mycobacterium tuberculosis Hypothetical protein 0.0149 0.0596 0.1612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0136 0.0141
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0166 0.0684 0.0684
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.0935
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0166 0.0684 0.1852
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0068 0.0174 0.0174
Echinococcus granulosus neuropeptide s receptor 0.0473 0.2289 0.2289
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0068 0.0174 0.0208
Schistosoma mansoni pyruvate carboxylase 0.0743 0.3696 0.3696
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.2289 0.2289
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0264 0.1197 0.1197
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0068 0.0174 0.047
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0264 0.1197 0.3233
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0264 0.1197 0.3238
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0068 0.0174 0.047
Trypanosoma cruzi acetyl-CoA carboxylase 0.1207 0.6121 0.7348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.1252 0.1252
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0548 0.0548
Echinococcus multilocularis peptidase Clp (S14 family) 0.0109 0.0386 0.0386
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0108 0.0108
Echinococcus granulosus carbonic anhydrase 0.0769 0.3834 0.3834
Echinococcus multilocularis carbonic anhydrase 0.0769 0.3834 0.3834
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0264 0.1197 0.1197
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0068 0.0174 0.047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0136 0.0136
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0145 0.0145
Trypanosoma brucei unspecified product 0.0488 0.2367 0.2367
Onchocerca volvulus 0.0043 0.0042 0.0289
Loa Loa (eye worm) hypothetical protein 0.0085 0.0259 0.0268
Brugia malayi steroid hormone receptor 0.0061 0.0136 0.0141
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0264 0.1197 0.1197
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.3941 0.3941
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0136 0.0136
Echinococcus granulosus GPCR family 2 0.0063 0.0145 0.0145
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0042 0.0042
Toxoplasma gondii hypothetical protein 0.0769 0.3834 0.3834
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0068 0.0174 0.0208
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0068 0.0174 0.018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0116 0.0142
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0108 0.015
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0109 0.0386 0.1043
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0314 0.1454 0.2024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0136 0.0141
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0068 0.0174 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0583 0.0605
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.195 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0259 0.0268
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0032 0.0115
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.2289 0.2289
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0769 0.3834 0.3976
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0136 0.0141
Leishmania major carboxylase, putative 0.0743 0.3696 0.3696
Echinococcus granulosus thymidylate synthase 0.0314 0.1454 0.1454
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0259 0.0259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0145 0.0145
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0333 0.1554 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0042 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.1289 0.1289
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0108 0.0112
Echinococcus multilocularis expressed conserved protein 0.0185 0.0784 0.0784
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0042 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0147 0.0583 0.1579
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0108 0.0292
Brugia malayi hypothetical protein 0.0103 0.0356 0.0369
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0136 0.0136
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0769 0.3834 0.3976
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0356 0.0495
Loa Loa (eye worm) hypothetical protein 0.0199 0.0854 0.0885
Schistosoma mansoni carbonic anhydrase-related 0.0769 0.3834 0.3834
Loa Loa (eye worm) hypothetical protein 0.0043 0.0042 0.0044
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0528 0.0528
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0116 0.0161
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0042 0.0151
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0068 0.0174 0.018
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0314 0.1454 0.3935
Echinococcus multilocularis protein dispatched 1 0.0097 0.0321 0.0321
Leishmania major carbamoyl-phosphate synthase, putative 0.0168 0.0694 0.0694
Brugia malayi nuclear hormone receptor 0.0061 0.0136 0.0141
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0068 0.0174 0.0222
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0042 0.0042
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0042 0.0044
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0042 0.0114
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0042 0.0114
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0166 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.0063 0.0145 0.0145
Toxoplasma gondii pyruvate carboxylase 0.0743 0.3696 0.3696
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.1607
Brugia malayi glutaminase DH11.1 0.0567 0.2778 0.2881
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0854 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0136 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0136 0.0141
Schistosoma mansoni peptidase Clp (S14 family) 0.0166 0.0684 0.0684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0583 0.1579
Echinococcus multilocularis thymidylate synthase 0.0314 0.1454 0.1454
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0136 0.0141
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0068 0.0174 0.0174
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0042 0.0042
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0136 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0358 0.097
Schistosoma mansoni coup transcription factor 0.0061 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0197 0.0847 0.0878
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0042 0.0114
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.1026 0.1064
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0042 0.0114
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.163 0.8331 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0314 0.1454 0.2008
Schistosoma mansoni hypothetical protein 0.0165 0.0679 0.0679
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0583 0.0583
Schistosoma mansoni hypothetical protein 0.0063 0.0145 0.0145
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0168 0.0694 0.1633
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0068 0.0174 0.0174
Echinococcus granulosus carbonic anhydrase 0.0769 0.3834 0.3834
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0847 0.0878
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0042 0.0058
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0743 0.3696 0.3696
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0032 0.0032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0042 0.0114
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0068 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0136 0.0141
Echinococcus multilocularis muscleblind protein 1 0.1543 0.7873 0.7873
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1882 0.9643 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0042 0.0114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0108 0.0609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0108 0.0108
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0147 0.0583 0.1579
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0136 0.0141
Mycobacterium ulcerans pyruvate carboxylase 0.0743 0.3696 1
Loa Loa (eye worm) glutaminase 0.0567 0.2778 0.2881
Echinococcus granulosus carbonic anhydrase II 0.163 0.8331 0.8331
Echinococcus multilocularis geminin 0.0165 0.0679 0.0679
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0145 0.015
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0356 0.0356
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.2289 0.2289
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0168 0.0694 0.0833
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0042 0.0042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0136 0.0136
Brugia malayi ecdysteroid receptor 0.0061 0.0136 0.0141
Loa Loa (eye worm) acetyltransferase 0.014 0.0548 0.0568
Loa Loa (eye worm) hypothetical protein 0.0769 0.3834 0.3976
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0583 0.0583
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0042 0.0114
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0259 0.0259
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0136 0.0934
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0264 0.1197 0.3238
Loa Loa (eye worm) hypothetical protein 0.0769 0.3834 0.3976
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0166 0.0684 0.1614
Loa Loa (eye worm) hypothetical protein 0.0061 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.1543 0.7873 0.8164
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0068 0.0174 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0136 0.0136

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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