Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0142 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0142 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0142 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0142 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0142 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0142 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0088 | 0.4444 | 0.0589 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0142 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.4097 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0142 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0142 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0088 | 0.4444 | 0.0589 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0088 | 0.4444 | 0.0589 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0088 | 0.4444 | 0.0589 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0142 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0085 | 0.4097 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0142 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0142 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0142 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.4097 | 0.4097 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0142 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0142 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.4097 | 0.4097 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4097 | 0.3237 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0142 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
IC50 (binding) | = 32 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.