Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3968 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1934 | 0.4844 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.3968 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1934 | 0.4844 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3968 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1934 | 0.4844 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0333 | 0.0786 | 0.0786 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3968 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0158 | 0.0344 | 0.0344 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3968 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0333 | 0.0786 | 0.0786 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1934 | 0.4844 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0333 | 0.0786 | 0.0786 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.0344 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3968 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0333 | 0.0786 | 0.0458 |
Loa Loa (eye worm) | thymidylate synthase | 0.0333 | 0.0786 | 0.0786 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3968 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3968 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3968 | 1 | 1 |
Onchocerca volvulus | 0.0333 | 0.0786 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1934 | 0.4844 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1934 | 0.4844 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0333 | 0.0786 | 0.0786 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1900 nM | Binding affinity against nicotinic receptors from rat brain using [3H]-cystine as radioligand | ChEMBL. | 11689081 |
Ki (binding) | = 1900 nM | Binding affinity against nicotinic receptors from rat brain using [3H]-cystine as radioligand | ChEMBL. | 11689081 |
Log Ki (binding) | = 5.72 | Compound was evaluated for pKi | ChEMBL. | 11689081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.