Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0007 | 0.0007 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0049 | 0.0049 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0049 | 0.0049 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.183 | 0.4931 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.37 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.37 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.37 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.37 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.37 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0049 | 0.0049 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.0315 | 0.0315 |
Echinococcus granulosus | thymidylate synthase | 0.0332 | 0.087 | 0.087 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0013 | 0.0013 |
Echinococcus granulosus | lamin | 0.0029 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | thymidylate synthase | 0.0332 | 0.087 | 0.087 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.0399 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.37 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0013 | 0.0013 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.0315 | 0.0315 |
Echinococcus multilocularis | thymidylate synthase | 0.0332 | 0.087 | 0.087 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0077 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0332 | 0.087 | 0.0855 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0735 | 0.1963 | 0.1963 |
Onchocerca volvulus | 0.0029 | 0.0049 | 0.0559 | |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0049 | 0.0049 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0735 | 0.1963 | 0.1963 |
Onchocerca volvulus | 0.0029 | 0.0049 | 0.0559 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.37 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0158 | 0.0399 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0007 | 0.0007 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.183 | 0.4931 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.0325 | 0.3729 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0049 | 0.0049 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0077 | 0.0077 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0008 | 0.0008 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0735 | 0.1963 | 0.1963 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Schistosoma mansoni | lamin | 0.0029 | 0.0049 | 0.0049 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.183 | 0.4931 | 1 |
Brugia malayi | thymidylate synthase | 0.0332 | 0.087 | 0.087 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.183 | 0.4931 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.0315 | 0.0315 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0049 | 0.0049 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0077 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0066 | 0.005 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.37 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0049 | 0.0049 |
Schistosoma mansoni | dihydrofolate reductase | 0.37 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0008 | 0.0008 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0077 | 0.0124 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0077 | 0.0124 |
Mycobacterium ulcerans | thymidylate synthase | 0.0332 | 0.087 | 0.0799 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0077 | 0.0077 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0077 | 0.0124 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Brugia malayi | hypothetical protein | 0.013 | 0.0325 | 0.0325 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.183 | 0.4931 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.0399 | 0.0399 |
Schistosoma mansoni | lamin | 0.0029 | 0.0049 | 0.0049 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.183 | 0.4931 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0077 | 0.0077 |
Onchocerca volvulus | 0.0332 | 0.087 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0049 | 0.0049 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0077 | 0.0124 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0049 | 0.0049 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.0325 | 0.3729 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0332 | 0.087 | 0.087 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0158 | 0.0399 | 0.0778 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0049 | 0.0049 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0008 | 0.0008 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0332 | 0.087 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0047 | 0.0047 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0016 | 0.0016 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0077 | 0.0124 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 2.51 uM | Antiproliferative activity against human melanoma UACC-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 2.51 uM | Antiproliferative activity against human melanoma UACC-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 6.51 uM | Antiproliferative activity against human ovarian OVCAR-3 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 6.51 uM | Antiproliferative activity against human ovarian OVCAR-3 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 11.5 uM | Antiproliferative activity against human lung HOP-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 11.5 uM | Antiproliferative activity against human lung HOP-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 11.6 uM | Antiproliferative activity against human breast MDA-MB-435 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 11.6 uM | Antiproliferative activity against human breast MDA-MB-435 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 12.9 uM | Antiproliferative activity against human colon HCT-116 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 12.9 uM | Antiproliferative activity against human colon HCT-116 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 26.7 uM | Antiproliferative activity against human renal SN12C cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 26.7 uM | Antiproliferative activity against human renal SN12C cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 31.9 uM | Antiproliferative activity against human prostate DU-145 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 31.9 uM | Antiproliferative activity against human prostate DU-145 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human CNS SF-539 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human CNS SF-539 cancer cell line | ChEMBL. | 11689077 |
MGM (functional) | = 10.3 uM | Mean graph midpoint value for cytotoxic activity against human cancer cell lines | ChEMBL. | 11689077 |
MGM (functional) | = 10.3 uM | Mean graph midpoint value for cytotoxic activity against human cancer cell lines | ChEMBL. | 11689077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.