Detailed information for compound 22150

Basic information

Technical information
  • TDR Targets ID: 22150
  • Name: 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-m ethylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]he ptalen-7-yl]acetamide
  • MW: 469.474 | Formula: C22H22F3NO5S
  • H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc2c(cc1=O)[C@H](CCc1c2c(OC)c(c(c1)OC)OC)NC(=O)C(F)(F)F
  • InChi: 1S/C22H22F3NO5S/c1-29-16-9-11-5-7-14(26-21(28)22(23,24)25)13-10-15(27)17(32-4)8-6-12(13)18(11)20(31-3)19(16)30-2/h6,8-10,14H,5,7H2,1-4H3,(H,26,28)/t14-/m0/s1
  • InChiKey: LNELBQZKXVASLW-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-(methylthio)-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ethanamide
  • 2,2,2-trifluoro-N-[(7S)-9-keto-1,2,3-trimethoxy-10-(methylthio)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-(methylthio)-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • 2,2,2-trifluoro-N-[(7S)-9-keto-1,2,3-trimethoxy-10-(methylthio)-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • 2,2,2-trifluoro-N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide
  • 76129-16-3
  • Colchicine derivative
  • AIDS-031411
  • AIDS031411
  • Acetamide, 2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
  • Acetamide, 2,2,2-trifluoro-N-[5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, (S)-
  • COLCHICHINE DERIV.
  • COLCHICINE DERIV
  • NSC320301
  • NCI60_002767

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0038 0.0029
Schistosoma mansoni Smad4 0.0018 0.0041 0.0026
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Loa Loa (eye worm) DR-78 0.0033 0.0165 0.0156
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0658 0.0643
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.052 0.0509
Loa Loa (eye worm) histone methyltransferase 0.0025 0.0099 0.0087
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0165 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0197 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0467 0.0471
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0041 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0467 0.0487
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0015 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0009
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0025 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.1178 0.1173
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0041 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0658 0.0671
Echinococcus multilocularis protein dispatched 1 0.0234 0.1812 0.1811
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0474 0.3788 0.8316
Loa Loa (eye worm) glutathione reductase 0.005 0.0307 0.0304
Brugia malayi CCR4 0.0016 0.0025 0.0026
Schistosoma mansoni smad 0.0018 0.0041 0.0026
Plasmodium falciparum glutathione reductase 0.005 0.0307 0.075
Brugia malayi Dihydrofolate reductase 0.0137 0.1023 0.1067
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0041 0.0037
Plasmodium falciparum thioredoxin reductase 0.0017 0.0038 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0467 0.0471
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0038 0.0035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0536 0.113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.2704 0.2711
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0025 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Onchocerca volvulus 0.0038 0.0209 0.0193
Echinococcus granulosus sterol regulatory element binding protein 0.0234 0.1812 0.1811
Schistosoma mansoni ap endonuclease 0.0078 0.0536 0.0525
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0197 0.019
Echinococcus multilocularis GPCR, family 2 0.0031 0.015 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0052 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0536 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0467 0.0471
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0342 0.2704 0.2821
Trypanosoma brucei polo-like protein kinase 0.0093 0.0658 0.1399
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0096 0.0157
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0041 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0209 0.0407
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0165 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0273 0.0263
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Brugia malayi Thioredoxin reductase 0.005 0.0307 0.032
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0025 0.0014
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0041 0.0025
Schistosoma mansoni cpg binding protein 0.0065 0.0431 0.042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.019
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0209 0.0199
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0658 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0099 0.0084
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0041 0.0037
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0567 0.455 1
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0025 0.0009
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0015 0.0016 0.0017
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0041 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0041 0.0043
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0266 0.2079 0.2071
Loa Loa (eye worm) hypothetical protein 0.0156 0.1178 0.1215
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0025 0.001
Brugia malayi hypothetical protein 0.0032 0.0156 0.0163
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0197 0.0184
Toxoplasma gondii thioredoxin reductase 0.005 0.0307 0.075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.0036
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0209 0.0698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0086
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.0016 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0467 0.0456
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0015 0.0016 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0658 0.1399
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.07 0.073
Schistosoma mansoni hypothetical protein 0.1223 0.9933 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0467 0.0455
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0052 0.0036
Schistosoma mansoni hypothetical protein 0.1223 0.9933 1
Echinococcus granulosus smad 0.0018 0.0041 0.0025
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0015 0.0016 0.0017
Schistosoma mansoni cript-related 0.0016 0.0025 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0165 0.0149
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0041 0.0037
Echinococcus granulosus Smad4 0.0018 0.0041 0.0025
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0567 0.455 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Schistosoma mansoni synaptojanin 0.0016 0.0025 0.001
Onchocerca volvulus 0.007 0.0467 0.0452
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0467 0.0455
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0467 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0467 0.0487
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0038 0.0065
Schistosoma mansoni smad1 5 8 and 0.0018 0.0041 0.0026
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0467 0.0455
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0467 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0474 0.3788 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0041 0.0026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0041 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0467 0.0471
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0658 0.1399
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0536 0.0526
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0307 0.0624
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0096 0.01
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0096 0.0189
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0209 0.0179
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0009
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0165 0.015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0467 0.0456
Echinococcus multilocularis Niemann Pick C1 protein 0.0234 0.1812 0.1811
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0467 0.0455
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Leishmania major hypothetical protein, conserved 0.0038 0.0209 0.0407
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0536 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.1897 0.7105
Entamoeba histolytica hypothetical protein 0.0076 0.052 0.7861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi nuclear receptor NHR-88 0.007 0.0467 0.0487
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0197 0.0183
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0834 0.3071
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0038 0.0028
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0068 0.0053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.015 0.0135
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0165 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0467 0.0471
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.015 0.0156
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0307 0.0293
Toxoplasma gondii ABC1 family protein 0.0038 0.0209 0.0489
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0016 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0165 0.015
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0041 0.0037
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0536 0.8101
Echinococcus granulosus GPCR family 2 0.0031 0.015 0.0135
Schistosoma mansoni cpg binding protein 0.0062 0.0402 0.0391
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0165 0.0156
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0209 0.0407
Brugia malayi MH2 domain containing protein 0.0018 0.0041 0.0043
Echinococcus multilocularis smad 0.0018 0.0041 0.0025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0834 0.3071
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0467 0.0487
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0209 0.0194
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0299 0.0607
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0025 0.0135
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.0014
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0052 0.0072
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0337 0.266 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.015 0.014
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0038 0.0035
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0658 0.0647
Schistosoma mansoni synaptojanin 0.0016 0.0025 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0467 0.0456
Mycobacterium ulcerans glutaminase 0.1181 0.9586 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0041 0.0026
Onchocerca volvulus 0.0033 0.0165 0.0149
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0536 0.1358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0467 0.0455
Echinococcus multilocularis cpg binding protein 0.0065 0.0431 0.0419
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0096 0.0157
Brugia malayi CXXC zinc finger family protein 0.0062 0.0402 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0209 0.0407
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0536 0.2488
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0474 0.3788 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0467 0.0487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0068 0.0053
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0015 0.0016 0.0001
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0234 0.1812 0.1876
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0939 0.2978
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0467 0.0487
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0299 0.073
Brugia malayi Smad1 0.0018 0.0041 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0467 0.0452
Onchocerca volvulus 0.0062 0.0402 0.0387
Brugia malayi beta-lactamase family protein 0.0038 0.0209 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0165 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0009
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.2704 0.2711
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0567 0.455 0.4747
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0025 0.0009
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0137 0.1023 0.1032
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0041 0.0043
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0052 0.0103
Loa Loa (eye worm) thymidylate synthase 0.0337 0.266 0.2763
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0445 0.0465
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0038 0.0029
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Onchocerca volvulus 0.0038 0.0209 0.0193
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.1466 0.1453
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0015 0.0016 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0041 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0467 0.0455
Schistosoma mansoni glutaminase 0.1181 0.9586 0.965
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0165 0.015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0165 0.0149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0467 0.0455
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0041 0.0037
Brugia malayi G-protein alpha subunit 0.0015 0.0016 0.0017
Brugia malayi nuclear receptor NHR-88 0.0033 0.0165 0.0172
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0099 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0467 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0052 0.0037
Brugia malayi conserved hypotetical protein 0.0033 0.0165 0.0172
Mycobacterium tuberculosis Probable reductase 0.0114 0.0834 0.3071
Brugia malayi Pax transcription factor protein 2 0.0291 0.228 0.2378
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0041 0.0037
Brugia malayi MH1 domain containing protein 0.0018 0.0041 0.0043
Leishmania major hypothetical protein, conserved 0.0049 0.0299 0.0607
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0209 0.0199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.0036
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Onchocerca volvulus 0.0033 0.0165 0.0149
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0858 0.6932 0.6974
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0038 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0536 0.0559
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0041 0.0026
Schistosoma mansoni kinase 0.0047 0.0283 0.027
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.015 0.0135
Schistosoma mansoni patched 1 0.0234 0.1812 0.1812
Echinococcus multilocularis synaptojanin 1 0.0016 0.0025 0.0009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0041 0.0026
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0041 0.0026
Mycobacterium tuberculosis Conserved protein 0.0038 0.0209 0.0698
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Schistosoma mansoni hypothetical protein 0.0076 0.052 0.051
Echinococcus granulosus histone lysine methyltransferase setb 0.0156 0.1178 0.1172
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0016 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0209 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0016 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0536 0.1358
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0038 0.0029
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0567 0.455 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0165 0.015
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0025 0.0014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0052 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.07 0.0715
Trichomonas vaginalis set domain proteins, putative 0.1232 1 1
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0025 0.0009
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0041 0.0025
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0015 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0467 0.0487
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0068 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.019
Brugia malayi hypothetical protein 0.0037 0.0197 0.0206
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0077 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0467 0.0471
Brugia malayi Pre-SET motif family protein 0.0156 0.1178 0.1229
Schistosoma mansoni ap endonuclease 0.0078 0.0536 0.0525
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0299 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0567 0.455 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.052 0.0509
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.0016 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0467 0.0452
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0467 0.0455
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0041 0.0394
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.0016 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0536 0.0524
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0467 0.0455
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0467 0.0456
Onchocerca volvulus 0.0038 0.0209 0.0193
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0939 0.3468
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0197 0.0183
Trichomonas vaginalis esterase, putative 0.0038 0.0209 0.0199
Echinococcus multilocularis dihydrofolate reductase 0.0137 0.1023 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0342 0.2704 0.2711
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0165 0.015
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0234 0.1812 0.1812
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0337 0.266 0.2667
Brugia malayi hypothetical protein 0.0049 0.0299 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0209 0.0489
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0041 0.0037
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0038 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0209 0.0698
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Giardia lamblia GTOR 0.0018 0.0041 0.0081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0467 0.0455
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0209 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0049 0.0299 0.0296
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.1178 0.1173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0025 0.0135
Brugia malayi isocitrate dehydrogenase 0.0019 0.0052 0.0054
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0209 0.0698
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0209 0.0195
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0467 0.0456
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0467 0.0487
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0025 0.0135
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0038 0.0029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0052 0.0038
Brugia malayi nuclear receptor RXR 0.0037 0.0197 0.0206
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0467 0.0487
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1082 0.8775 0.9153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Giardia lamblia Kinase, PLK 0.0093 0.0658 0.3081
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0165 0.015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0834 0.3071
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0041 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0197 0.0206
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0834 0.2551
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Schistosoma mansoni cpg binding protein 0.0065 0.0431 0.042
Brugia malayi thymidylate synthase 0.0337 0.266 0.2775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0467 0.0455
Echinococcus granulosus FTZ F1 alpha 0.007 0.0467 0.0455
Loa Loa (eye worm) dihydrofolate reductase 0.0137 0.1023 0.1052
Brugia malayi MH2 domain containing protein 0.0018 0.0041 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi hypothetical protein 0.0076 0.052 0.0543
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0038 0.0029
Onchocerca volvulus 0.0291 0.228 0.2268
Echinococcus granulosus thymidylate synthase 0.0337 0.266 0.2667
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0658 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0474 0.3788 0.8316
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0567 0.455 0.4573
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0041 0.0037
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.016 0.1211 0.2621
Echinococcus multilocularis Smad4 0.0018 0.0041 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Brugia malayi nuclear hormone receptor 0.0033 0.0165 0.0172
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0041 0.0026
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.052 0.051
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0307 0.075
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0165 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Loa Loa (eye worm) hypothetical protein 0.0098 0.07 0.0715
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0038 0.0035
Loa Loa (eye worm) glutaminase 2 0.1181 0.9586 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0467 0.0471
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0536 0.194
Plasmodium falciparum glutathione reductase 0.0017 0.0038 0.0035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0165 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0041 0.0026
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.228 0.2366
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0299 0.073
Entamoeba histolytica hypothetical protein 0.0076 0.052 0.7861
Echinococcus multilocularis protein patched 0.0234 0.1812 0.1811
Loa Loa (eye worm) hypothetical protein 0.0191 0.1466 0.1516
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0536 0.0521
Echinococcus multilocularis geminin 0.1223 0.9933 1
Brugia malayi ecdysteroid receptor 0.007 0.0467 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0467 0.0471
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0025 0.001
Onchocerca volvulus 0.0016 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Brugia malayi MH1 domain containing protein 0.0018 0.0041 0.0043
Treponema pallidum NADH oxidase 0.0017 0.0038 0.026
Schistosoma mansoni nuclear receptor 0.0033 0.0165 0.0151
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0165 0.015
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0536 0.0543
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0025 0.0009
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.0136
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0299 0.0607
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0038 0.0029
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0156 0.1178 0.3066
Echinococcus multilocularis thymidylate synthase 0.0337 0.266 0.2667
Onchocerca volvulus 0.0337 0.266 0.2649
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0658 0.0647
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0939 0.3468
Echinococcus granulosus synaptojanin 1 0.0016 0.0025 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0209 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0068 0.0054
Brugia malayi glutaminase DH11.1 0.1181 0.9586 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0567 0.455 0.4572
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0658 0.1399
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.019
Brugia malayi CHE-14 protein 0.0234 0.1812 0.189
Loa Loa (eye worm) MH2 domain-containing protein 0.0261 0.2033 0.2107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0902 0.2333
Brugia malayi hypothetical protein 0.0037 0.0197 0.0206
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0137 0.1023 0.3321
Schistosoma mansoni smad1 5 8 and 0.0018 0.0041 0.0026
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0025 0.0014
Brugia malayi hypothetical protein 0.0033 0.0165 0.0172
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0038 0.0039
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0041 0.0394
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0137 0.1023 0.3787
Onchocerca volvulus 0.0016 0.0025 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0939 0.3468
Onchocerca volvulus 0.0156 0.1178 0.1164
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0068 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0299 0.073
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0041 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0536 0.113
Echinococcus granulosus dihydrofolate reductase 0.0137 0.1023 0.1015
Toxoplasma gondii exonuclease III APE 0.0078 0.0536 0.1358
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0165 0.015
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0467 0.0456
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0025 0.0009
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0038 0.0028
Schistosoma mansoni coup transcription factor 0.007 0.0467 0.0456
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0096 0.0081
Schistosoma mansoni zinc finger protein 0.0033 0.0165 0.0151
Brugia malayi Pre-SET motif family protein 0.1082 0.8775 0.9154
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0025 0.0135
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0834 0.3071
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0467 0.0487
Loa Loa (eye worm) glutaminase 0.1181 0.9586 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.0016 0.0001
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0015 0.0016 0.0017
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0567 0.455 0.4726
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0165 0.0172
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0165 0.015
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0025 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0834 0.3071
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0041 0.0025
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.0016 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0038 0.005
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.0016 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0536 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0445 0.0449
Brugia malayi nuclear receptor NHR-67 0.0033 0.0165 0.0172
Chlamydia trachomatis dihydrofolate reductase 0.0137 0.1023 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0342 0.2704 0.2711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0096 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0467 0.0455
Echinococcus granulosus geminin 0.1223 0.9933 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Schistosoma mansoni thyroid hormone receptor 0.007 0.0467 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Schistosoma mansoni thyroid hormone receptor 0.007 0.0467 0.0456
Schistosoma mansoni nuclear hormone receptor 0.007 0.0467 0.0456
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0016 0.0001
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0025 0.0014
Mycobacterium tuberculosis Conserved protein 0.0038 0.0209 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0467 0.0487
Plasmodium vivax SET domain protein, putative 0.0156 0.1178 0.3066
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0052 0.006
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0337 0.266 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.0016 0.0006
Brugia malayi beta-lactamase 0.0038 0.0209 0.0218
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0025 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0149 0.112 0.1114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0536 0.0524
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0209 0.0698
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0342 0.2704 0.2711
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0025 0.0009
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0025 0.0014
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0015 0.0016 0.0006
Brugia malayi glutathione reductase 0.005 0.0307 0.032
Leishmania major trypanothione reductase 0.005 0.0307 0.0624
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0025 0.0009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0307 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0467 0.0455
Brugia malayi tailless protein 0.0033 0.0165 0.0172
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0038 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0209 0.0199
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0015 0.0016 0.0001
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0025 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0156 0.1178 0.1172
Trichomonas vaginalis glutaminase, putative 0.1181 0.9586 0.9585
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.006
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.0016 0.0001
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0266 0.2079 0.2071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0165 0.015
Loa Loa (eye worm) beta-lactamase 0.0038 0.0209 0.0201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0467 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.1178 0.1173
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0052 0.0072
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0009
Brugia malayi beta-lactamase family protein 0.0038 0.0209 0.0218
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0022
Entamoeba histolytica hypothetical protein 0.0076 0.052 0.7861
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.0136
Brugia malayi MH2 domain containing protein 0.0261 0.2033 0.212
Brugia malayi steroid hormone receptor 0.007 0.0467 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.015 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0273 0.0263
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0025 0.0009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0165 0.015
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0015 0.0016 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0041 0.0037
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0052 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0536 0.113
Brugia malayi hypothetical protein 0.0015 0.0016 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0209 0.0201
Echinococcus multilocularis sterol regulatory element binding protein 0.0234 0.1812 0.1811
Mycobacterium ulcerans lipase LipD 0.0038 0.0209 0.0179
Loa Loa (eye worm) hypothetical protein 0.0567 0.455 0.4738
Brugia malayi N-terminal motif family protein 0.0191 0.1466 0.153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0342 0.2704 0.2711
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0536 0.0526
Trypanosoma brucei trypanothione reductase 0.005 0.0307 0.0624
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0467 0.0455
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0041 0.0037
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0026
Brugia malayi hypothetical protein 0.0033 0.0165 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0467 0.0487
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0165 0.0172
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0474 0.3788 0.8316
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0015 0.0016 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0307 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.1812 0.1803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0156 0.1178 0.1173
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0209 0.0698
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0156 0.1178 0.1172
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Schistosoma mansoni dihydrofolate reductase 0.0137 0.1023 0.1016
Plasmodium falciparum thioredoxin reductase 0.005 0.0307 0.075
Brugia malayi Latrophilin receptor protein 2 0.0031 0.015 0.0156
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0041 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0467 0.0456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.1017 0.1011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.2704 0.2711
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0467 0.0487
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0467 0.0455
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.0036
Schistosoma mansoni hypothetical protein 0.0067 0.0445 0.0434
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0197 0.0206
Schistosoma mansoni hypothetical protein 0.0022 0.0077 0.0062
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0097 0.0101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0209 0.0179
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0307 0.0293
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0052 0.006
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0467 0.0487
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0299 0.0607
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0025 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0658 0.0648
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0209 0.0698
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0266 0.2079 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0209 0.0698
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.0136
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0096 0.0081
Loa Loa (eye worm) hypothetical protein 0.0234 0.1812 0.1876
Echinococcus granulosus cpg binding protein 0.0065 0.0431 0.0419
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0077 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0016 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0209 0.0195
Brugia malayi dihydrofolate reductase family protein 0.0137 0.1023 0.1067
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0068 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0467 0.0452
Loa Loa (eye worm) Smad1 0.0018 0.0041 0.0026
Schistosoma mansoni smad1 5 8 and 0.0018 0.0041 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0467 0.0487
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0041 0.0027
Brugia malayi nuclear hormone receptor 0.007 0.0467 0.0487
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0165 0.0156
Loa Loa (eye worm) transcription factor SMAD2 0.0261 0.2033 0.2107
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.0016 0.0001
Entamoeba histolytica hypothetical protein 0.0024 0.0096 0.1244
Mycobacterium ulcerans beta-lactamase 0.0038 0.0209 0.0179
Mycobacterium ulcerans thymidylate synthase 0.0337 0.266 0.2747
Schistosoma mansoni nocturnin 0.0016 0.0025 0.001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0052 0.0072
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0474 0.3788 1
Brugia malayi nuclear receptor RXR 0.0033 0.0165 0.0172
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Echinococcus granulosus Niemann Pick C1 protein 0.0234 0.1812 0.1811
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0402 0.0404
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0041 0.0026
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.0016 0.0001
Brugia malayi hypothetical protein 0.016 0.1211 0.1263
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0567 0.455 0.4572
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0471
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0038 0.0035
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0025 0.0135
Brugia malayi ecdysone receptor 0.0033 0.0165 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.016 0.1211 0.1202
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.0016 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.015 0.0135
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0658 0.0686
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0025 0.0014
Schistosoma mansoni nuclear receptor 0.0033 0.0165 0.0151
Entamoeba histolytica hypothetical protein 0.0076 0.052 0.7861
Mycobacterium tuberculosis Hypothetical protein 0.016 0.1211 0.45
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0342 0.2704 0.2809
Echinococcus granulosus Protein patched homolog 1 0.0234 0.1812 0.1811
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0165 0.0172
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0209 0.0194
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0165 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0156
Mycobacterium ulcerans hypothetical protein 0.0038 0.0209 0.0179
Mycobacterium tuberculosis Conserved protein 0.0038 0.0209 0.0698
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0467 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0165 0.0151
Plasmodium vivax glutathione reductase, putative 0.005 0.0307 0.075
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0041 0.0037
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0266 0.2079 0.2071
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0165 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0041 0.0031
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0165 0.0172
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0467 0.0487
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.07 0.073

Activities

Activity type Activity value Assay description Source Reference
Binding (binding) = 81 % Binding affinity towards tubulin protein measured by their ability to displace [3H]-colchicine from rat brain at the dose 2.5 M ChEMBL. 4032423
Binding (binding) = 81 % Binding affinity towards tubulin protein measured by their ability to displace [3H]-colchicine from rat brain at the dose 2.5 M ChEMBL. 4032423
Binding (binding) = 98 % Binding affinity towards tubulin protein measured by their ability to displace [3H]-colchicine from rat brain at the dose 25 uM ChEMBL. 4032423
Binding (binding) = 98 % Binding affinity towards tubulin protein measured by their ability to displace [3H]-colchicine from rat brain at the dose 25 uM ChEMBL. 4032423
Dose (functional) = 0.62 mg kg-1 Antitumor activity against P388 lymphocytic leukemia in mice ChEMBL. 4032423
Dose (functional) = 0.62 mg kg-1 Antitumor activity against P388 lymphocytic leukemia in mice ChEMBL. 4032423
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.837 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 1.3 nM Anti tumor activity of the compound on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment ChEMBL. 10602712
IC50 (functional) = 1.3 nM Anti tumor activity of the compound on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment ChEMBL. 10602712
IC50 (functional) = 35 nM Anti tumor activity of the compound on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment ChEMBL. 10602712
IC50 (functional) = 35 nM Anti tumor activity of the compound on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment ChEMBL. 10602712
LD50 (ADMET) = 0.9 mg kg-1 Leathel dose of the compound was determined after the intraperitoneall injection in a group of 10 mice ChEMBL. 4032423
LD50 (ADMET) = 0.9 mg kg-1 Leathel dose of the compound was determined after the intraperitoneall injection in a group of 10 mice ChEMBL. 4032423
LD50 (ADMET) = 1.4 mg kg-1 Compound was tested for toxicity in P388 tumored mice ChEMBL. 7241524
LD50 (ADMET) = 3.5 mg kg-1 Compound was tested for toxicity in nontumored mice ChEMBL. 7241524
Log 1/C (functional) = 6.23 Antitumor activity against murine lymphocytic leukemia P388 cells ChEMBL. 7265111
logP (ADMET) = 2.99 Partition coefficient (logP) ChEMBL. 7265111
MED (functional) = 0.32 MED(minimum effective dose) against P388 lymphocytic leukemia in mice; this dose produced T/C greater than the threshold value of 125 ChEMBL. 4032423
T/C (functional) = 148 Compound was evaluated for the antitumor activity against P388 lymphocytic leukemia in mice ChEMBL. 4032423

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10602712

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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