Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.072 | 0.0453 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.072 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0689 | 0.0955 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.072 | 0.0453 |
Onchocerca volvulus | 0.0036 | 0.0748 | 0.0606 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.072 | 0.1036 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0032 | 0.0605 | 0.087 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.0467 | 0.0242 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.072 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.0467 | 1 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0037 | 0.0796 | 0.1206 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0324 | 0.0466 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.4559 | 0.8501 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.287 | 0.5145 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0467 | 0.3606 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.5313 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.5313 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0072 | 0.2107 | 0.4269 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.072 | 1 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0036 | 0.0748 | 0.1086 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0467 | 0.0295 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.287 | 0.5145 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0689 | 0.0991 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.0467 | 0.037 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.072 | 0.0674 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.4559 | 0.8501 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.072 | 0.0453 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0467 | 0.8498 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0492 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0492 | 0.0333 |
Onchocerca volvulus | 0.0072 | 0.2107 | 0.2369 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.4559 | 0.642 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0487 | 0.0325 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.028 | 0.0403 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.4823 | 0.6938 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0339 | 0.0104 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Brugia malayi | Bromodomain containing protein | 0.0028 | 0.0467 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4559 | 0.642 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0467 | 0.0436 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4559 | 0.8501 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.6951 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0467 | 0.0295 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.072 | 0.0874 |
Echinococcus granulosus | peregrin | 0.0028 | 0.0467 | 0.037 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0467 | 0.3606 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4559 | 0.6559 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0072 | 0.2107 | 0.3629 |
Echinococcus multilocularis | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.072 | 0.1028 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0492 | 0.0708 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.4823 | 0.9025 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.072 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.4491 | 0.9842 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.072 | 0.0453 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.4491 | 0.9842 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0037 | 0.0796 | 0.1206 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0467 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1221 | 0.1424 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.4823 | 0.9025 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.072 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0492 | 0.0421 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.287 | 0.4129 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.072 | 0.0453 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0037 | 0.0796 | 0.1025 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.072 | 0.0453 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0037 | 0.0796 | 0.1025 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.028 | 0.0403 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0689 | 0.0812 |
Schistosoma mansoni | transmemberane protein | 0.0072 | 0.2107 | 0.4269 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0452 | 0.0341 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.4823 | 0.9025 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4559 | 0.642 |
Onchocerca volvulus | 0.0029 | 0.0492 | 0.0274 | |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0138 | 0.4583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4823 | 0.6814 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0492 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4823 | 0.6814 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0689 | 0.0628 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0072 | 0.2107 | 0.3629 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0467 | 0.0436 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0072 | 0.2107 | 0.4269 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.088 | 0.1192 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.072 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.028 | 0.0016 |
Echinococcus multilocularis | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.072 | 0.0453 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0037 | 0.0796 | 0.0788 |
Brugia malayi | hypothetical protein | 0.0023 | 0.028 | 0.0403 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0283 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0283 | 1 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0689 | 0.0812 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.072 | 0.0874 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0689 | 0.0955 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.5313 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0467 | 0.037 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0492 | 0.0495 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.2159 | 0.4391 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.072 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0138 | 0.4583 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.028 | 0.0403 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0467 | 0.0671 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.1591 | 0.1978 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.7993 | 0.7935 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.028 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2107 | 0.275 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4559 | 0.8501 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.4559 | 0.642 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.088 | 0.1192 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2107 | 0.275 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0032 | 0.0605 | 0.0502 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.5313 | 0.7644 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0138 | 0.4583 | 1 |
Onchocerca volvulus | 0.0072 | 0.2107 | 0.2369 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0796 | 0.0788 |
Onchocerca volvulus | 0.0091 | 0.2825 | 0.3299 | |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0072 | 0.2107 | 0.4269 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.4559 | 1 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0037 | 0.0796 | 0.1146 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.028 | 0.0016 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4559 | 0.6559 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0037 | 0.0796 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0324 | 0.0081 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.5313 | 0.7549 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0072 | 0.2107 | 0.4269 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0492 | 0.0495 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0492 | 0.0421 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0492 | 0.0495 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.6951 | 1 |
Onchocerca volvulus | 0.023 | 0.7993 | 1 | |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0072 | 0.2107 | 0.3629 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4559 | 0.8501 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.028 | 0.0016 |
Echinococcus granulosus | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4559 | 0.8501 |
Echinococcus granulosus | nervana 2 | 0.0072 | 0.2107 | 0.3629 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0492 | 0.4244 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22.3 uM | Inhibition of [125I]-angiotensin II specific binding to rat mesenteric arteries | ChEMBL. | 1433195 |
IC50 (binding) | = 22.3 uM | Inhibition of [125I]-angiotensin II specific binding to rat mesenteric arteries | ChEMBL. | 1433195 |
Kb (functional) | = 0.97 uM | Inhibition of angiotensin II induced vasoconstriction of rabbit aorta | ChEMBL. | 1433195 |
Kb (functional) | = 0.97 uM | Inhibition of angiotensin II induced vasoconstriction of rabbit aorta | ChEMBL. | 1433195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.