Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0629 | 0.7093 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0629 | 0.7093 | 1 |
Schistosoma mansoni | immunophilin | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0542 | 0.5961 | 0.8404 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0629 | 0.7093 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0629 | 0.7093 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0629 | 0.7093 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0629 | 0.7093 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0629 | 0.7093 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0542 | 0.5961 | 0.8404 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0629 | 0.7093 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0629 | 0.7093 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0087 | 0 | 0.5 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1072 | 0.1512 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0629 | 0.7093 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0309 | 0.2907 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0629 | 0.7093 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.1072 | 0.1512 |
Echinococcus multilocularis | fk506 binding protein | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.1072 | 0.1512 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0542 | 0.5961 | 0.8404 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1072 | 0.1512 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0309 | 0.2907 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0542 | 0.5961 | 0.8404 |
Leishmania major | fk506-binding protein 1-like protein | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0629 | 0.7093 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.7 uM | In vitro anti-HIV activity was determined in PBM cells infected with HIV-1 | ChEMBL. | 12540238 |
IC50 (functional) | > 100 uM | Evaluated in vitro for their potential toxic effects on uninfected PHA-stimulated human PBM cells | ChEMBL. | 12540238 |
IC50 (functional) | > 100 uM | Evaluated in vitro for their potential toxic effects human CEM cells | ChEMBL. | 12540238 |
IC50 (functional) | > 100 uM | Evaluated in vitro for their potential toxic effects against Vero cells | ChEMBL. | 12540238 |
IC50 (functional) | > 100 uM | Evaluated in vitro for their potential toxic effects human CEM cells | ChEMBL. | 12540238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.