Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Acute tolerability (functional) | Acute tolerability of compound in 4 ICR female mice after intravenous administration was determined; Lethality 5/5 | ChEMBL. | 12930152 | |
Acute tolerability (functional) | 0 | Acute tolerability of compound in 4 ICR female mice after intravenous administration was determined; Lethality 5/5 | ChEMBL. | 12930152 |
Kd app (binding) | = 0.1 nM | Apperent binding affinity against DNA (5'-ACAATTAA-3') was determined using DNase I footprinting titration method | ChEMBL. | 12930152 |
MIC (functional) | = 0.062 ug ml-1 | In vitro antimicrobial activity against penicillin resistant S. pneumoniae 51422 | ChEMBL. | 12930152 |
MIC (functional) | = 0.25 ug ml-1 | In vitro antimicrobial activity against penicillin-intermediate S. pneumoniae 49619 | ChEMBL. | 12930152 |
MIC (functional) | = 0.5 ug ml-1 | In vitro antimicrobial activity against vancomycin-susceptible E. faecalis 29212 | ChEMBL. | 12930152 |
MIC (functional) | = 0.5 ug ml-1 | In vitro antimicrobial activity against vancomycin-resistant E. faecalis 51559 | ChEMBL. | 12930152 |
MIC (functional) | = 0.5 ug ml-1 | In vitro antimicrobial activity against Bacillus cereus 11778 | ChEMBL. | 12930152 |
MIC (functional) | = 2 ug ml-1 | In vitro antimicrobial activity against methicillin resistant S. aureus 27660 | ChEMBL. | 12930152 |
MIC (functional) | > 32 ug ml-1 | In vitro antimicrobial activity against Candida albicans 38247 | ChEMBL. | 12930152 |
MIC (functional) | > 32 ug ml-1 | In vitro antimicrobial activity against Candida albicans 38247 | ChEMBL. | 12930152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.