Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin II receptor, type 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline O-acetyltransferase | 0.0158 | 0.7663 | 0.7663 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0158 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.7663 | 0.7663 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0196 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0196 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0196 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0196 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0158 | 0.7663 | 0.7663 |
Brugia malayi | Choline O-acetyltransferase | 0.0158 | 0.7663 | 0.7663 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0158 | 0.7663 | 0.7663 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0158 | 0.7663 | 0.7663 |
Brugia malayi | Carboxylesterase family protein | 0.0196 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0196 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0196 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0196 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0033 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | <= 5 | Tested for the antagonism of AII-induced contraction in rabbit endothelium-denuded aorta strips | ChEMBL. | 7966154 |
Ki (binding) | > 10 uM | Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex) | ChEMBL. | 7966154 |
Ki (binding) | > 10 uM | Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex) | ChEMBL. | 7966154 |
pA2 (functional) | <= 5 | Tested for the antagonism of AII-induced contraction in rabbit endothelium-denuded aorta strips | ChEMBL. | 7966154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.