Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Plasmodium falciparum | adenosylhomocysteinase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.2 uM | Inhibitory activity of the compound against mammalian FM3A cell | ChEMBL. | 14592485 |
EC50 (functional) | = 7.2 uM | Inhibitory activity of the compound against mammalian FM3A cell | ChEMBL. | 14592485 |
EC50 (functional) | = 7.4 uM | Inhibitory activity of the compound against P. falciparum human malaria parasite | ChEMBL. | 14592485 |
EC50 (functional) | = 7.4 uM | Inhibitory activity of the compound against P. falciparum human malaria parasite | ChEMBL. | 14592485 |
IC50 (binding) | = 13 uM | Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
IC50 (binding) | = 13 uM | Inhibition of Plasmodium falciparum SAHH | ChEMBL. | 18295495 |
IC50 (binding) | = 13 uM | Inhibition of human recombinant SAHH | ChEMBL. | 18374570 |
IC50 (binding) | = 13 uM | Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
IC50 (binding) | = 13 uM | Inhibition of Plasmodium falciparum SAHH | ChEMBL. | 18295495 |
IC50 (binding) | = 13 uM | Inhibition of human recombinant SAHH | ChEMBL. | 18374570 |
IC50 (binding) | = 63 uM | Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
IC50 (binding) | = 63 uM | Inhibition of human SAHH | ChEMBL. | 18295495 |
IC50 (binding) | = 63 uM | Inhibition of Plasmodium falciparum recombinant SAHH | ChEMBL. | 18374570 |
IC50 (binding) | = 63 uM | Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
IC50 (binding) | = 63 uM | Inhibition of human SAHH | ChEMBL. | 18295495 |
Ki (binding) | = 0.48 uM | Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
Ki (binding) | = 0.48 uM | Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
Ki (binding) | = 7.9 uM | Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
Ki (binding) | = 7.9 uM | Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
Ratio IC50 (binding) | = 4.8 | Selectivity ratio of IC50 for human SAHH to IC50 for Plasmodium falciparum SAHH | ChEMBL. | 18295495 |
Ratio IC50 (binding) | = 4.8 | Selectivity ratio of human recombinant SAHH to Plasmodium falciparum recombinant SAHH | ChEMBL. | 18374570 |
Selectivity index (functional) | = 0.97 | Mean value of mammalian FM3A cell to that of P. falciparum. | ChEMBL. | 14592485 |
Selectivity index (binding) | = 16 | Mean value of human S-adenosyl-L-homocysteine hydrolase to that of P. falciparum S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 14592485 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 14592485 | |
Plasmodium falciparum | ChEMBL23 | 14592485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.