Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0546 | 0.5981 | 0.8404 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0633 | 0.7116 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0633 | 0.7116 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0633 | 0.7116 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0633 | 0.7116 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0633 | 0.7116 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0633 | 0.7116 | 1 |
Schistosoma mansoni | immunophilin | 0.0546 | 0.5981 | 0.8404 |
Schistosoma mansoni | immunophilin | 0.0633 | 0.7116 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0633 | 0.7116 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0633 | 0.7116 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0633 | 0.7116 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0633 | 0.7116 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0087 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0633 | 0.7116 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0633 | 0.7116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5981 | 0.8404 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0633 | 0.7116 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0633 | 0.7116 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0546 | 0.5981 | 0.8404 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0633 | 0.7116 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0087 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0308 | 0.2884 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0633 | 0.7116 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0633 | 0.7116 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0633 | 0.7116 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0633 | 0.7116 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0633 | 0.7116 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0633 | 0.7116 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0633 | 0.7116 | 1 |
Schistosoma mansoni | immunophilin | 0.0633 | 0.7116 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0308 | 0.2884 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.09 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 2-cyclinE | ChEMBL. | 12190313 |
IC50 (binding) | = 0.09 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 2-cyclinE | ChEMBL. | 12190313 |
IC50 (binding) | = 5.16 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 4-cyclinD1 | ChEMBL. | 12190313 |
IC50 (binding) | = 5.16 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 4-cyclinD1 | ChEMBL. | 12190313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.