Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.3086 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0103 | 0.1852 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0103 | 0.1852 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0103 | 0.1852 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0103 | 0.1852 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.3086 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.3086 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0103 | 0.1852 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.3086 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0354 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0103 | 0.1852 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.3086 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0103 | 0.1852 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0094 | 0.1563 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.3086 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.3086 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.3086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3086 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0103 | 0.1852 | 0.1278 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0169 | 0.3985 | 0.5 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0354 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0103 | 0.1852 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.3086 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0103 | 0.1852 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.3086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3086 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0103 | 0.1852 | 0.6002 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0354 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0354 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0354 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0354 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0186 | 0.4547 | 0.3308 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0186 | 0.4547 | 0.3308 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.3086 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0354 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 10 uM | Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma. | ChEMBL. | 8289199 |
EC50 (functional) | = 10 uM | Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma. | ChEMBL. | 8289199 |
IC50 (binding) | = 0.005 uM | Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets. | ChEMBL. | 8289199 |
IC50 (binding) | = 0.005 uM | Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets. | ChEMBL. | 8289199 |
IC50 (binding) | = 0.052 uM | Displacement of the high affinity radiolabeled ligand [3H]- SQ-29,548 from the PGH-2/TXA-2 receptor in human gel-filtered platelets. | ChEMBL. | 8289199 |
IC50 (binding) | = 0.052 uM | Displacement of the high affinity radiolabeled ligand [3H]- SQ-29,548 from the PGH-2/TXA-2 receptor in human gel-filtered platelets. | ChEMBL. | 8289199 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8289199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.