Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vasopressin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Onchocerca volvulus | Vasopressin receptor | 425 aa | 392 aa | 21.9 % | |
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Loa Loa (eye worm) | hypothetical protein | Vasopressin receptor | 425 aa | 370 aa | 24.3 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Vasopressin receptor | 425 aa | 355 aa | 26.2 % |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Half-maximal inhibition of binding of [3H]-Oxytocin to OT receptor in rat uterine tissue | ChEMBL. | 1331449 |
IC50 (binding) | = 0.46 uM | Half-maximal inhibition of binding of [3H]-Oxytocin to OT receptor in rat uterine tissue | ChEMBL. | 1331449 |
IC50 (binding) | = 10 uM | Half-maximal inhibition of binding of [3H]-vasopressin to vaspressin receptor 1 in rat liver | ChEMBL. | 1331449 |
IC50 (binding) | > 10 uM | Half-maximal inhibition of binding of [3H]- vasopressin to the vasopressin receptor 2 in rat kidney | ChEMBL. | 1331449 |
IC50 (binding) | = 10 uM | Half-maximal inhibition of binding of [3H]-vasopressin to vaspressin receptor 1 in rat liver | ChEMBL. | 1331449 |
IC50 (binding) | > 10 uM | Half-maximal inhibition of binding of [3H]- vasopressin to the vasopressin receptor 2 in rat kidney | ChEMBL. | 1331449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.