TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.841 | Formula: C21H20ClNO3
H donors: 0 H acceptors: 1 LogP: 3.89 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C1=CCN(CC1)CCC(=O)c1ccc2c(c1)OCO2
InChi: 1S/C21H20ClNO3/c22-18-4-1-15(2-5-18)16-7-10-23(11-8-16)12-9-19(24)17-3-6-20-21(13-17)26-14-25-20/h1-7,13H,8-12,14H2
InChiKey: IPTPJVIPJMEHMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Dopamine D2 receptor	Starlite/ChEMBL	References
Homo sapiens	sigma non-opioid intracellular receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Dopamine D2 receptor	444 aa	464 aa	27.4 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Dopamine D2 receptor	444 aa	466 aa	20.2 %
Echinococcus granulosus	biogenic amine 5HT receptor	Dopamine D2 receptor	444 aa	430 aa	30.5 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D2 receptor	444 aa	464 aa	29.3 %
Schistosoma mansoni	amine GPCR	Dopamine D2 receptor	444 aa	424 aa	32.3 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Dopamine D2 receptor	444 aa	479 aa	22.8 %
Schistosoma mansoni	biogenic amine receptor	Dopamine D2 receptor	444 aa	455 aa	29.5 %
Echinococcus multilocularis	g protein coupled receptor	Dopamine D2 receptor	444 aa	465 aa	21.7 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D2 receptor	444 aa	432 aa	30.6 %
Echinococcus granulosus	g protein coupled receptor	Dopamine D2 receptor	444 aa	457 aa	21.7 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Dopamine D2 receptor	444 aa	493 aa	26.8 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D2 receptor	444 aa	438 aa	29.9 %
Echinococcus multilocularis	serotonin receptor	Dopamine D2 receptor	444 aa	446 aa	31.8 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Dopamine D2 receptor	444 aa	386 aa	19.9 %
Onchocerca volvulus		Dopamine D2 receptor	444 aa	417 aa	23.3 %
Schistosoma japonicum	Octopamine receptor, putative	Dopamine D2 receptor	444 aa	456 aa	28.7 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Dopamine D2 receptor	444 aa	489 aa	24.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0029	0.0001	0.0001
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0046	0.013	0.013
Giardia lamblia	Cathepsin L-like protease	0.0029	0.0001	0.0002
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0722
Plasmodium falciparum	serine repeat antigen 5	0.0029	0.0001	0.0002
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.035	0.1064
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.0136	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0227	0.148	0.2476
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0002	0.0002
Brugia malayi	Trypsin family protein	0.0046	0.013	0.0217
Trichomonas vaginalis	fk506-binding protein, putative	0.047	0.3292	1
Giardia lamblia	Cathepsin B precursor	0.0029	0.0001	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Onchocerca volvulus		0.0182	0.1143	0.2835
Loa Loa (eye worm)	calpain D	0.0033	0.0032	0.0054
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0058	0.0176
Echinococcus multilocularis	Mastin	0.0046	0.013	0.013
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0105	0.0572	0.0572
Brugia malayi	hypothetical protein	0.0049	0.0154	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Echinococcus granulosus	lysosomal alpha glucosidase	0.0165	0.1015	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0156
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0341	0.0341
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0064	0.0064
Onchocerca volvulus		0.0076	0.035	0.0869
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.0583	0.0975
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Plasmodium falciparum	serine repeat antigen 7	0.0029	0.0001	0.0002
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0209	0.0209
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.047	0.3292	0.5506
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0029	0.0001	0.0003
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0065	0.0268	0.5
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.0583	0.0975
Echinococcus granulosus	calpain	0.011	0.0607	0.0607
Entamoeba histolytica	hypothetical protein	0.0074	0.0341	0.1034
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Schistosoma mansoni	calpain (C02 family)	0.011	0.0607	0.0607
Brugia malayi	calpain 5	0.0033	0.0032	0.0054
Loa Loa (eye worm)	beta-lactamase	0.0076	0.035	0.0586
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.035	0.0107
Entamoeba histolytica	hypothetical protein	0.0029	0.0001	0.0002
Plasmodium falciparum	serine repeat antigen 2	0.0029	0.0001	0.0002
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.035	0.035
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0058	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0055	0.0169
Trypanosoma cruzi	centrin-3	0.0052	0.0173	0.0289
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0136	0.0136
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0062	0.0249	0.0249
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0064	0.0195
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0136	0.0136
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0065	0.0268	0.0448
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0572	0.1737
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Brugia malayi	calpain family protein 1	0.0292	0.1965	0.3287
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.3102	0.5188
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0197	0.1252	0.2094
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.0136	0.0413
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.0583	1
Loa Loa (eye worm)	calpain	0.011	0.0607	0.1016
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0065	0.0268	0.5
Echinococcus multilocularis	cathepsin b	0.083	0.5979	0.5979
Echinococcus multilocularis	calpain 5	0.011	0.0607	0.0607
Trypanosoma cruzi	kinesin, putative	0.0077	0.036	0.0602
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Schistosoma mansoni	gabp alpha	0.0073	0.0332	0.0332
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	esterase, putative	0.0076	0.035	0.1064
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0066	0.0066
Brugia malayi	fibroinase precursor	0.0029	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0001	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0003	0.001
Trypanosoma brucei	glucosidase, putative	0.0037	0.0058	0.0079
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0157	0.0157
Schistosoma mansoni	chromobox protein	0.0074	0.0335	0.0335
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Trypanosoma cruzi	cysteine proteinase, putative	0.0036	0.0055	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0064	0.0064
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Brugia malayi	beta-lactamase	0.0076	0.035	0.0586
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0001	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0003	0.001
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0064	0.0195
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Brugia malayi	Pre-SET motif family protein	0.0211	0.1356	0.2268
Loa Loa (eye worm)	hypothetical protein	0.005	0.0157	0.0263
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0064	0.0064
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.0136	0.0338
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0693	0.1718
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.047	0.3292	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0143	0.024
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1252	0.2094
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0277	0.185	0.5575
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0029	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1965	0.3287
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0055	0.0169
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0055	0.0169
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0157	0.0263
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0058	0.0176
Loa Loa (eye worm)	MBCTL1	0.0057	0.0209	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0215	0.139	0.2325
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0029	0.0001	0.0002
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.0335	0.056
Toxoplasma gondii	hypothetical protein	0.0033	0.0032	0.0174
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.1164	0.1164
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Echinococcus multilocularis	mitogen activated protein kinase	0.0105	0.0572	0.0572
Giardia lamblia	Cathepsin L-like protease	0.0029	0.0001	0.0002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0197	0.1252	0.2094
Brugia malayi	mbt repeat family protein	0.005	0.0157	0.0263
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Brugia malayi	6-phosphofructokinase	0.0107	0.0583	0.0975
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0277	0.185	0.185
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0583	0.1771
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Mycobacterium tuberculosis	Probable oxidoreductase	0.1103	0.8011	1
Plasmodium falciparum	serine repeat antigen 9	0.0029	0.0001	0.0002
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.0217
Schistosoma mansoni	hypothetical protein	0.0062	0.0249	0.0249
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0046	0.013	0.013
Trichomonas vaginalis	fk506-binding protein, putative	0.0065	0.0268	0.0813
Loa Loa (eye worm)	hypothetical protein	0.083	0.5979	1
Schistosoma mansoni	chromobox protein	0.0074	0.0335	0.0335
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.047	0.3292	1
Echinococcus granulosus	cathepsin b	0.083	0.5979	0.5979
Loa Loa (eye worm)	fibroinase	0.0047	0.0136	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Onchocerca volvulus		0.0095	0.0496	0.1231
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0277	0.185	0.3093
Echinococcus granulosus	calpain A	0.0315	0.2138	0.2138
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.035	0.0976
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0166	0.0277
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.027	0.1801	0.3013
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.1583	0.2648
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0029	0.0001	0.0001
Leishmania major	hypothetical protein, conserved	0.0076	0.035	0.0976
Onchocerca volvulus		0.0047	0.0136	0.0338
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0335	0.1017
Echinococcus granulosus	cysteine protease	0.0036	0.0055	0.0055
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0065	0.0268	0.0813
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.3102	0.5188
Echinococcus granulosus	mitogen activated protein kinase 3	0.0105	0.0572	0.0572
Giardia lamblia	Hypothetical protein	0.0029	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0062	0.0249	0.0249
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0105	0.0572	0.1655
Brugia malayi	Latrophilin receptor protein 2	0.0062	0.0249	0.0417
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0315	0.2138	0.2138
Trichomonas vaginalis	fk506-binding protein, putative	0.0065	0.0268	0.0813
Brugia malayi	Heterochromatin protein 1	0.0074	0.0335	0.056
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0065	0.0268	0.0813
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0058	0.0058
Toxoplasma gondii	cathepsin CPC1	0.0029	0.0001	0.0003
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.0081	0.0136
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.047	0.3292	0.3292
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Onchocerca volvulus		0.0065	0.0268	0.0664
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0277	0.185	0.5619
Trypanosoma cruzi	major cysteine proteinase, putative	0.0029	0.0001	0.0001
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1016
Leishmania major	hypothetical protein, conserved	0.0035	0.0045	0.0039
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0788	0.1317
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0136
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0136	0.0228
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1016
Trichomonas vaginalis	calpain, putative	0.0033	0.0032	0.0098
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0029	0.0001	0.0001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.083	0.5979	0.5979
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0065	0.0268	0.1447
Plasmodium vivax	unspecified product	0.0029	0.0001	0.0002
Schistosoma mansoni	calpain-7 (C02 family)	0.0113	0.063	0.063
Loa Loa (eye worm)	trypsin family protein	0.0046	0.013	0.0217
Trypanosoma cruzi	centrin, putative	0.0052	0.0173	0.0289
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0062	0.0249	0.0249
Echinococcus granulosus	cathepsin l1	0.0047	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0673	0.4804	0.4804
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0693	0.1159
Giardia lamblia	Hypothetical protein	0.0029	0.0001	0.0002
Echinococcus granulosus	transmembrane protease serine 3	0.0046	0.013	0.013
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0032	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0001	0.0002
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.0583	0.0583
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0136	0.0413
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0136	0.0228
Giardia lamblia	Cathepsin B precursor	0.0029	0.0001	0.0002
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD)	0.0065	0.0268	0.0811
Brugia malayi	cathepsin L-like precursor	0.004	0.0081	0.0136
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.035	0.0107
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0055	0.0093
Brugia malayi	Ets-domain containing protein	0.0073	0.0332	0.0555
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.0136	0.0413
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.035	0.1064
Schistosoma mansoni	calpain-7 (C02 family)	0.0113	0.063	0.063
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0341	0.0341
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0058	0.0176
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0029	0.0001	0.0002
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.047	0.3292	0.5506
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.047	0.3292	0.5506
Trypanosoma brucei	protein kinase, putative	0.0105	0.0572	0.1655
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0065	0.0268	0.0448
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1765
Echinococcus granulosus	cathepsin l1	0.004	0.0081	0.0081
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.0583	0.0975
Trypanosoma cruzi	cysteine protease, putative	0.0036	0.0055	0.0093
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.0332	0.0555
Schistosoma mansoni	cathepsin S (C01 family)	0.0029	0.0001	0.0001
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.035	0.1064
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.0583	0.1689
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0064	0.0107
Toxoplasma gondii	cathepsin B	0.0277	0.185	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0136
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0154	0.0467
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0774	0.5562	0.5562
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0722
Leishmania major	kinesin, putative	0.0077	0.036	0.1006
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0165	0.1015	0.1697
Echinococcus multilocularis	calpain family protein 1, d	0.0215	0.139	0.139
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0065	0.0268	0.0268
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0064	0.0064
Schistosoma mansoni	ets-related	0.0222	0.1444	0.1444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Leishmania major	fk506-binding protein 1-like protein	0.047	0.3292	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	set domain proteins, putative	0.024	0.1573	0.4778
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0064	0.0195
Entamoeba histolytica	hypothetical protein	0.0074	0.0341	0.1034
Trichomonas vaginalis	calcium binding protein, putative	0.0052	0.0173	0.0525
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.047	0.3292	1
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.0136	0.0318
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0081	0.0246
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0583	0.1771
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.035	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0405	0.2809	0.4698
Giardia lamblia	Cathepsin B precursor	0.0277	0.185	0.5619
Loa Loa (eye worm)	calpain 5	0.0077	0.036	0.0602
Mycobacterium tuberculosis	Conserved protein	0.0076	0.035	0.0107
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0065	0.0268	0.0813
Plasmodium falciparum	serine repeat antigen 6	0.0029	0.0001	0.0002
Giardia lamblia	Kinase, CMGC MAPK	0.0105	0.0572	0.1737
Schistosoma mansoni	hypothetical protein	0.0065	0.0268	0.0268
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Echinococcus granulosus	FK506 binding protein 2	0.0065	0.0268	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0001	0.0003
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0673	0.4804	0.4804
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0607	0.1765
Loa Loa (eye worm)	hypothetical protein	0.0259	0.1718	0.2873
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0185	0.1164	0.1947
Brugia malayi	hypothetical protein	0.0032	0.0023	0.0039
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.083	0.5979	0.5979
Entamoeba histolytica	calpain family cysteine protease, putative	0.0033	0.0032	0.0098
Echinococcus multilocularis	programmed cell death protein	0.0052	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0569	0.4031	0.6741
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0001	0.0002
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.3102	0.9418
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.047	0.3292	1
Entamoeba histolytica	protein kinase, putative	0.0078	0.0367	0.1116
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0315	0.2138	0.2138
Plasmodium falciparum	serine repeat antigen 8	0.0029	0.0001	0.0002
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.0583	0.0575
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0209	0.0209
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.0065	0.0268	0.0448
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0335	0.1017
Echinococcus granulosus	calpain 5	0.011	0.0607	0.0607
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.047	0.3292	1
Trypanosoma cruzi	Aph-1 protein, putative	0.0302	0.2036	0.3405
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0136	0.0228
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0029	0.0001	0.0002
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.0136	0.0136
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0065	0.0268	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0136	0.0228
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Schistosoma mansoni	bromodomain containing protein	0.0066	0.0279	0.0279
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0045	0.0075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.047	0.3292	1
Giardia lamblia	Cysteine protease	0.0029	0.0001	0.0002
Echinococcus granulosus	neuropeptide receptor A26	0.0501	0.3522	0.3522
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.1015	0.1015
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0157	0.0157
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Giardia lamblia	Cysteine protease	0.0029	0.0001	0.0002
Onchocerca volvulus		0.0042	0.01	0.0249
Plasmodium vivax	unspecified product	0.0036	0.0055	0.0169
Echinococcus granulosus	cathepsin L cysteine protease	0.0036	0.0055	0.0055
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0001	0.0002
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0117	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0058	0.0176
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0081	0.0081
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.001	0.001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0185	0.1164	0.1164
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Plasmodium vivax	vivapain-1	0.0036	0.0055	0.0169
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.011	0.0607	0.1016
Brugia malayi	cathepsin B-like cysteine proteinase	0.083	0.5979	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0055	0.0055
Brugia malayi	MH2 domain containing protein	0.012	0.068	0.1137
Onchocerca volvulus		0.0569	0.4031	1
Onchocerca volvulus		0.0029	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0843	0.0843
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0185	0.1164	0.1164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.1164	0.1164
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0046	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Schistosoma mansoni	immunophilin	0.047	0.3292	0.3292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Schistosoma mansoni	hypothetical protein	0.0134	0.0788	0.0788
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Giardia lamblia	Cathepsin B precursor	0.0029	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0103	0.0172
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0058	0.0097
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0036	0.0055	0.0169
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0001	0.0002
Toxoplasma gondii	cathepsin CPL	0.0047	0.0136	0.0736
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0136
Trypanosoma cruzi	cysteine proteinase, putative	0.0036	0.0055	0.0093
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Brugia malayi	cathepsin L-like cysteine proteinase	0.0029	0.0001	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0065	0.0268	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0143	0.0143
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0157	0.0391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0029	0.0001	0.0002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0185	0.1164	0.1164
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.047	0.3292	0.5506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.0217
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0065	0.0268	0.0448
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0062	0.0249	0.0249
Echinococcus multilocularis	calpain	0.011	0.0607	0.0607
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0058	0.0097
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0136	0.0413
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Mycobacterium tuberculosis	Conserved protein	0.0076	0.035	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0268	0.0813
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0001	0.0002
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0029	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.047	0.3292	0.5506
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.035	0.2622
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0001	0.0001
Echinococcus multilocularis	cathepsin L	0.0029	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Loa Loa (eye worm)	fli-1 protein	0.0222	0.1444	0.2416
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0029	0.0001	0.0002
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.068	0.1137
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1765
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0154	0.0257
Echinococcus granulosus	calpain A	0.011	0.0607	0.0607
Giardia lamblia	Cysteine protease	0.0029	0.0001	0.0002
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1016
Echinococcus multilocularis	cysteine protease	0.0047	0.0136	0.0136
Trypanosoma brucei	hypothetical protein, conserved	0.0065	0.0268	0.0722
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0001	0.0003
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0029	0.0001	0.0002
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0055	0.0055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1765
Toxoplasma gondii	cathepsin CPC2	0.0029	0.0001	0.0003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Brugia malayi	Cathepsin L-like precursor	0.004	0.0081	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0136	0.0413
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.035	0.1064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.1164	0.1164
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0055	0.0169
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0029	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Loa Loa (eye worm)	FKBP5 protein	0.047	0.3292	0.5506
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0065	0.0268	0.0448
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.047	0.3292	0.5506
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0185	0.1164	0.1164
Echinococcus granulosus	GPCR family 2	0.0062	0.0249	0.0249
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0058	0.0176
Schistosoma mansoni	calpain-2 (C02 family)	0.0033	0.0032	0.0032
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.0583	0.0583
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.035	0.0107
Brugia malayi	MAP kinase sur-1	0.0105	0.0572	0.0956
Plasmodium vivax	calpain, putative	0.011	0.0607	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0268	0.0448
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.035	0.035
Plasmodium vivax	serine-repeat antigen (SERA)	0.0029	0.0001	0.0002
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.0154	0.0467
Onchocerca volvulus		0.0046	0.013	0.0321
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0572	0.0572
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0197	0.1252	0.2094
Trypanosoma cruzi	centrin, putative	0.0052	0.0173	0.0289
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0335	0.0335
Echinococcus multilocularis	geminin	0.0673	0.4804	0.4804
Mycobacterium ulcerans	hypothetical protein	0.0076	0.035	0.028
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Onchocerca volvulus		0.004	0.0081	0.0201
Trichomonas vaginalis	calpain, putative	0.0033	0.0032	0.0098
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0722
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0055	0.0169
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0136	0.0228
Plasmodium falciparum	serine repeat antigen 4	0.0029	0.0001	0.0002
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0064	0.0195
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0136	0.0136
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0064	0.0107
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0209	0.0209
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0117	0.0289
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0143	0.0143
Echinococcus granulosus	programmed cell death protein	0.0052	0.0173	0.0173
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Schistosoma mansoni	calpain C (C02 family)	0.011	0.0607	0.0607
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Echinococcus granulosus	neuropeptide s receptor	0.0501	0.3522	0.3522
Schistosoma mansoni	hypothetical protein	0.0307	0.2079	0.2079
Brugia malayi	Ets-domain containing protein	0.0073	0.0332	0.0555
Echinococcus multilocularis	glycoprotein Antigen 5	0.0046	0.013	0.013
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.0572	0.0956
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0029	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0055	0.0093
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.0583	0.0975
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.047	0.3292	0.4012
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.047	0.3292	0.3292
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0029	0.0001	0.0002
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0065	0.0268	0.1447
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0055	0.0055
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0062	0.0249	0.0249
Schistosoma mansoni	hypothetical protein	0.0062	0.0249	0.0249
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0607	0.1765
Brugia malayi	gamma-secretase subunit aph-1	0.0774	0.5562	0.9302
Plasmodium falciparum	calpain	0.0033	0.0032	0.0098
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0157	0.0157
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.1179	0.3582
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.0217
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0136	0.0338
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0001	0.0001
Brugia malayi	Bromodomain containing protein	0.004	0.0084	0.0141
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0166	0.0277
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0065	0.0268	0.1447
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0033	0.0032	0.0054
Echinococcus granulosus	gamma secretase subunit aph 1	0.0774	0.5562	0.5562
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0607	0.1765
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0136	0.0338
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.035	0.0107
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0066	0.0066
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0058	0.0097
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.0583	0.1769
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0001	0.0002
Echinococcus multilocularis	neuropeptide receptor A26	0.0501	0.3522	0.3522
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.0217
Brugia malayi	cathepsin L precursor	0.0029	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0081	0.0246
Echinococcus multilocularis	microtubule associated protein 2	0.1369	1	1
Onchocerca volvulus		0.024	0.1573	0.3902
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.3102	0.9418
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0405	0.2809	0.2809
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0055	0.0071
Trichomonas vaginalis	fk506 binding protein, putative	0.0065	0.0268	0.0813
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0583	0.1771
Onchocerca volvulus		0.0047	0.0136	0.0338
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0154	0.0257
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0583	0.1771
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0055	0.0093
Brugia malayi	phosphofructokinase	0.0107	0.0583	0.0975
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0154	0.0467
Brugia malayi	Pre-SET motif family protein	0.003	0.001	0.0017
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0583	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0154	0.0257
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0001	0.0002
Echinococcus multilocularis	neuropeptide s receptor	0.0501	0.3522	0.3522
Onchocerca volvulus		0.0523	0.3686	0.9145
Onchocerca volvulus		0.0047	0.0136	0.0338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0136	0.0413
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0185	0.1164	0.1947
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0029	0.0001	0.0002
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Echinococcus granulosus	tissue type plasminogen activator	0.0035	0.0045	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0143	0.0143
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.035	0.0107
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Schistosoma mansoni	immunophilin	0.047	0.3292	0.3292
Brugia malayi	hypothetical protein	0.0046	0.013	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1143	0.1911
Onchocerca volvulus		0.0065	0.0268	0.0664
Plasmodium vivax	vivapain-2	0.0047	0.0136	0.0413
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.0572	0.0956
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0001	0.0002
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0046	0.013	0.0217
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0064	0.0064
Giardia lamblia	Cathepsin B precursor	0.0029	0.0001	0.0002
Mycobacterium leprae	Probable lipase LipE	0.0076	0.035	0.2622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0029	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0569	0.4031	0.6741
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0315	0.2138	0.2138
Trypanosoma brucei	kinesin, putative	0.0077	0.036	0.1006
Onchocerca volvulus		0.0046	0.013	0.0321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1016
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0572	0.1737
Entamoeba histolytica	cysteine proteinase 2	0.0036	0.0055	0.0169
Schistosoma mansoni	fk506 binding protein	0.0065	0.0268	0.0268
Trypanosoma brucei	antigen, putative	0.011	0.0607	0.1765
Brugia malayi	latrophilin 2 splice variant baaae	0.0134	0.0788	0.1317
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0341	0.0341
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0118	0.0197
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0058	0.0097
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0693	0.1718
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1016
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.047	0.3292	1
Brugia malayi	calpain 5	0.0077	0.036	0.0602
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0055	0.0169
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Echinococcus granulosus	calpain 7 C02 family	0.011	0.0607	0.0607
Trichomonas vaginalis	calmodulin, putative	0.0052	0.0173	0.0525
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.047	0.3292	1
Brugia malayi	beta-lactamase family protein	0.0076	0.035	0.0586
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.035	0.0586
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.0332	0.0332
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0105	0.0572	0.1655
Echinococcus granulosus	chromobox protein 1	0.0074	0.0335	0.0335
Echinococcus granulosus	geminin	0.0673	0.4804	0.4804
Trichomonas vaginalis	immunophilin, putative	0.047	0.3292	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.083	0.5979	0.5979
Brugia malayi	6-phosphofructokinase	0.0107	0.0583	0.0975
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.035	0.1064
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0143	0.0143
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0001	0.0002
Giardia lamblia	Cathepsin B precursor	0.0277	0.185	0.5619
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0033	0.0032	0.0054
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0001	0.0002
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0843	0.0843
Loa Loa (eye worm)	cathepsin B	0.0277	0.185	0.3093
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.047	0.3292	1
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0065	0.0268	0.0448
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0036	0.0055	0.0093
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0105	0.0572	0.3091
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0065	0.0268	0.1447
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0165	0.1015	0.1697
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.047	0.3292	0.3292
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0058	0.0176
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.1583	0.2648
Brugia malayi	hypothetical protein	0.0074	0.0341	0.0569
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.035	0.035
Trypanosoma brucei	Aph-1 protein, putative	0.0302	0.2036	0.6147
Brugia malayi	mbt repeat family protein	0.005	0.0157	0.0263
Echinococcus granulosus	mitogen activated protein kinase	0.0105	0.0572	0.0572
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0117	0.0354
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1765
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0251	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0029	0.0001	0.0001
Trypanosoma cruzi	kinesin, putative	0.0077	0.036	0.0602
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0064	0.0195
Mycobacterium tuberculosis	Conserved protein	0.0076	0.035	0.0107
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0774	0.5562	0.5562
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0252	0.0422
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0033	0.0032	0.0098
Entamoeba histolytica	hypothetical protein	0.0074	0.0341	0.1034
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0065	0.0268	0.0722
Schistosoma mansoni	immunophilin	0.0405	0.2809	0.2809
Schistosoma mansoni	hypothetical protein	0.0074	0.0341	0.0341
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0136	0.0228
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0105	0.0572	0.1655
Echinococcus multilocularis	GPCR, family 2	0.0062	0.0249	0.0249
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0209	0.0209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Echinococcus granulosus	cathepsin L	0.0029	0.0001	0.0001
Brugia malayi	Trypsin-like protease protein 5	0.0046	0.013	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0249	0.0417
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0583	0.1771
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Brugia malayi	calpain D	0.0033	0.0032	0.0054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.035	0.028
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Plasmodium vivax	SET domain protein, putative	0.003	0.001	0.0031
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0813
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0405	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Loa Loa (eye worm)	calpain family protein 1	0.0292	0.1965	0.3287
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.0154	0.0831
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0001	0.0002
Trypanosoma cruzi	Aph-1 protein, putative	0.0302	0.2036	0.3405
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0065	0.0268	0.0722
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0029	0.0001	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.035	0.0586
Brugia malayi	Bromodomain containing protein	0.0078	0.0371	0.062
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0093	0.0283
Echinococcus granulosus	cathepsin L	0.0036	0.0055	0.0055
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0292	0.1965	0.1965
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0569	0.4031	0.4031
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0058	0.0058
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0209	0.0209
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0105	0.0572	0.0956
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0036	0.0055	0.0169
Giardia lamblia	Cysteine protease	0.0029	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0445	0.3102	0.5188
Brugia malayi	calpain 7	0.011	0.0607	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.0583	0.0407
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0058	0.0176
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Loa Loa (eye worm)	TK/ROR protein kinase	0.0035	0.0045	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0268	0.0813
Plasmodium vivax	serine-repeat antigen (SERA)	0.0029	0.0001	0.0002
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0813
Echinococcus multilocularis	calpain A	0.0315	0.2138	0.2138
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0029	0.0001	0.0002
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.0136	0.0228
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Brugia malayi	Trypsin family protein	0.0569	0.4031	0.6741
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0448
Onchocerca volvulus		0.0046	0.013	0.0321
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0136	0.0228
Brugia malayi	Cathepsin L-like precursor	0.004	0.0081	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0209	0.0349
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0065	0.0268	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0337	0.0564
Echinococcus multilocularis	calpain 7 (C02 family)	0.011	0.0607	0.0607
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.035	0.0107
Brugia malayi	calpain family protein 1	0.0292	0.1965	0.3287
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0315	0.2138	0.2138
Entamoeba histolytica	grainin 2	0.0052	0.0173	0.0525
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.004	0.0081	0.0136
Leishmania major	peptidylprolyl isomerase-like protein	0.047	0.3292	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0029	0.0001	0.0002
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0693	0.1159
Onchocerca volvulus		0.0046	0.013	0.0321
Brugia malayi	Trypsin family protein	0.0046	0.013	0.0217
Echinococcus granulosus	chromobox protein 1	0.0074	0.0335	0.0335
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0105	0.0572	0.0956
Giardia lamblia	Hypothetical protein	0.0065	0.0268	0.0813
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0065	0.0268	0.0268
Onchocerca volvulus	Glucosylceramidase homolog	0.0177	0.1108	0.2749
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.0332	0.0332
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0029	0.0001	0.0002
Echinococcus multilocularis	transmembrane protease serine 3	0.0046	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0058	0.0176
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0046	0.013	0.013
Trypanosoma cruzi	major cysteine proteinase, putative	0.0029	0.0001	0.0001
Onchocerca volvulus		0.0047	0.0136	0.0338
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0062	0.0249	0.0417
Echinococcus granulosus	cathepsin b	0.083	0.5979	0.5979
Onchocerca volvulus		0.0046	0.013	0.0321
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0569	0.4031	0.4031
Schistosoma mansoni	alpha glucosidase	0.0037	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Brugia malayi	Kringle domain containing protein	0.0035	0.0045	0.0075
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0064	0.0107
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Plasmodium falciparum	serine repeat antigen 1	0.0029	0.0001	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Giardia lamblia	Encystation-specific protease	0.0029	0.0001	0.0002
Mycobacterium ulcerans	hypothetical protein	0.0065	0.0268	0.0175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Echinococcus multilocularis	cathepsin L	0.0036	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0029	0.0001	0.0002
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0077	0.036	0.1094
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0157	0.0157
Brugia malayi	cathepsin F-like cysteine proteinase	0.0029	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0027	0.0045
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0058	0.0176
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.1356	0.2268
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0058	0.0313
Leishmania major	hypothetical protein, conserved	0.0049	0.0154	0.0373
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0064	0.0098
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.035	0.028
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0157	0.0157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0055	0.0071
Mycobacterium ulcerans	short chain dehydrogenase	0.1103	0.8011	1
Brugia malayi	Trypsin family protein	0.0046	0.013	0.0217
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1801	0.5472
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.047	0.3292	1
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0035	0.0045	0.0137
Plasmodium falciparum	serine repeat antigen 3	0.0029	0.0001	0.0002
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.083	0.5979	0.5979
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0277	0.185	0.5575
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0064	0.0107
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0141
Entamoeba histolytica	hypothetical protein	0.0074	0.0341	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0075
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0001	0.0001
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0201	0.1282	0.1282
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0136	0.0136
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0001	0.0002
Giardia lamblia	Cathepsin B precursor	0.0029	0.0001	0.0002
Giardia lamblia	Cathepsin B precursor	0.0277	0.185	0.5619
Mycobacterium ulcerans	lipase LipD	0.0076	0.035	0.028
Loa Loa (eye worm)	hypothetical protein	0.0046	0.013	0.0217
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0033	0.0032	0.0174
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0058	0.0176
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.0583	0.0583
Schistosoma mansoni	cercarial elastase (S01 family)	0.0046	0.013	0.013
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.047	0.3292	0.5506
Mycobacterium ulcerans	beta-lactamase	0.0076	0.035	0.028
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0054
Onchocerca volvulus		0.0047	0.0136	0.0338
Echinococcus multilocularis	programmed cell death protein	0.0052	0.0173	0.0173
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.0136	0.0136
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1016
Brugia malayi	Protein kinase domain containing protein	0.0035	0.0045	0.0075
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.001	0.0056
Onchocerca volvulus		0.0047	0.0136	0.0338
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.1179	0.3582
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0001	0.0002
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.0583	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Trypanosoma brucei	calpain-like protein, putative	0.011	0.0607	0.1765
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0093	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0076	0.035	0.0586
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0001	0.0002
Brugia malayi	beta-lactamase family protein	0.0076	0.035	0.0586
Schistosoma mansoni	microtubule-associated protein tau	0.1369	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.035	0.035
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0201	0.1282	0.1282
Schistosoma mansoni	cathepsin B (C01 family)	0.0029	0.0001	0.0001
Loa Loa (eye worm)	ctsf protein	0.0047	0.0136	0.0228
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1016
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0136	0.0413
Trypanosoma brucei	caltractin, putative	0.0052	0.0173	0.0432
Plasmodium falciparum	cysteine repeat modular protein 1	0.0035	0.0045	0.0137
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0583	0.1771
Plasmodium vivax	vivapain-2	0.0047	0.0136	0.0413
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0033	0.0032	0.0054
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0001	0.0001
Trypanosoma cruzi	conserved protein	0.0033	0.0032	0.0054
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1108	0.3366
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0001	0.0002
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0065	0.0268	0.0448
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0001	0.0002
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.047	0.3292	0.3292
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1016
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.0583	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0093	0.0283
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0251	0.0251
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.035	0.0107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0572	0.1737
Onchocerca volvulus		0.0076	0.035	0.0869
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0572	0.1737
Trypanosoma brucei	centrin-3	0.0052	0.0173	0.0432
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.0154	0.0373
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.083	0.5979	1
Trichomonas vaginalis	hypothetical protein	0.0033	0.0032	0.0098
Loa Loa (eye worm)	calpain family protein 1	0.0215	0.139	0.2325
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0607	0.1016
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.068	0.1137
Brugia malayi	hypothetical protein	0.0122	0.0693	0.1159
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0029	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.01	0.01
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Echinococcus granulosus	glycoprotein Antigen 5	0.0046	0.013	0.013
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.047	0.3292	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0065	0.0268	0.0813
Schistosoma mansoni	Mername-AA248 (C02 family)	0.011	0.0607	0.0607
Leishmania major	cathepsin L-like protease	0.0047	0.0136	0.0318
Schistosoma mansoni	cathepsin C	0.0029	0.0001	0.0001
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0062	0.0249	0.0417
Loa Loa (eye worm)	cysteine protease	0.0047	0.0136	0.0228
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0209	0.0349
Schistosoma mansoni	hypothetical protein	0.0035	0.0045	0.0045
Echinococcus multilocularis	cathepsin b	0.083	0.5979	0.5979
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.1015	0.1015
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0774	0.5562	0.9302
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.027	0.1801	0.3013
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0001	0.0002
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0157	0.0157
Echinococcus multilocularis	fk506 binding protein	0.047	0.3292	0.3292
Giardia lamblia	Cathepsin L precursor	0.0029	0.0001	0.0002
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.0607	0.1765
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0064	0.0064
Onchocerca volvulus		0.0047	0.0136	0.0338
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0033	0.0032	0.0054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Echinococcus granulosus	enteropeptidase	0.0046	0.013	0.013
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0033	0.0032	0.0054
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0105	0.0572	0.0956
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0033	0.0032	0.0054
Onchocerca volvulus		0.0032	0.0027	0.0066
Brugia malayi	chromobox protein homolog 3	0.0041	0.0093	0.0156
Onchocerca volvulus		0.0076	0.035	0.0869
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.001	0.001
Toxoplasma gondii	kringle domain-containing protein	0.0035	0.0045	0.0244
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0136	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0081	0.0246
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0484	0.3396	0.404
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0157	0.0157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0136	0.0413
Toxoplasma gondii	ABC1 family protein	0.0076	0.035	0.1894
Echinococcus multilocularis	hypothetical protein	0.011	0.0607	0.0607
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0029	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.035	0.1064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0001	0.0002
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase, putative	0.0065	0.0268	0.0813
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.035	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0136	0.0413
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.0136	0.0228
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0029	0.0001	0.0002
Plasmodium vivax	vivapain-3	0.0036	0.0055	0.0169
Trichomonas vaginalis	calpain, putative	0.0033	0.0032	0.0098
Brugia malayi	Fli-1 protein	0.0222	0.1444	0.2416
Echinococcus granulosus	Mastin	0.0046	0.013	0.013
Onchocerca volvulus		0.005	0.0157	0.0391
Schistosoma mansoni	hypothetical protein	0.0062	0.0249	0.0249
Echinococcus multilocularis		0.0065	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0136	0.0318
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0064	0.0098
Echinococcus multilocularis	cysteine protease	0.0047	0.0136	0.0136
Onchocerca volvulus		0.0035	0.0045	0.0112
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0058	0.0176
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Echinococcus multilocularis	tissue type plasminogen activator	0.0035	0.0045	0.0045
Echinococcus multilocularis	enteropeptidase	0.0046	0.013	0.013
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0001	0.0002
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0065	0.0268	0.0448
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0055	0.0169
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0136	0.0136

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 281 nM	Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperone	ChEMBL.	7902869
IC50 (binding)	= 281 nM	Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperone	ChEMBL.	7902869
IC50 (binding)	> 5000 nM	Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin	ChEMBL.	7902869
IC50 (binding)	> 5000 nM	Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin	ChEMBL.	7902869

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL340532

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 222078