Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0291 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0291 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0291 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0291 | 1 | 0.5 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0291 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0291 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0291 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0291 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0291 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0291 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0291 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Onchocerca volvulus | 0.0291 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0291 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0291 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0291 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0291 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0291 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = -4.5 % | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedb at 100 microM | ChEMBL. | 8254620 |
Inhibition (binding) | = -4.5 % | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedb at 100 microM | ChEMBL. | 8254620 |
Inhibition (binding) | = 8.6 % | Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined | ChEMBL. | 8254620 |
Inhibition (binding) | = 8.6 % | Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined | ChEMBL. | 8254620 |
Inhibition (functional) | = 11 % | Inhibition of lipid peroxidation in rat liver microsomes at 1 microM | ChEMBL. | 8254620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.