Detailed information for compound 222159

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.303 | Formula: C14H18N2O5
  • H donors: 3 H acceptors: 3 LogP: 0.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1Nc2cc(O)c(cc2C(=O)N2[C@H]1CC(C2)O)OC
  • InChi: 1S/C14H18N2O5/c1-20-12-4-8-9(5-11(12)18)15-13(21-2)10-3-7(17)6-16(10)14(8)19/h4-5,7,10,13,15,17-18H,3,6H2,1-2H3/t7?,10-,13+/m0/s1
  • InChiKey: FDZKMDGYTVIWIB-GLWCPXLYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0587 0.0665
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Brugia malayi Inositol-1 0.0038 0.0295 0.0339
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0424 0.05
Echinococcus granulosus S formylglutathione hydrolase 0.0031 0.0208 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0347 0.0398
Brugia malayi larval opioid receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0129 0.1405 0.1612
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0255 0.2091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.027 0.2214
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0101 0.0101
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0347 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.4282
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0243
Brugia malayi hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0334
Loa Loa (eye worm) hypothetical protein 0.0061 0.0568 0.0652
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0031 0.0208 0.0236
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1048 0.1202
Loa Loa (eye worm) hypothetical protein 0.0048 0.0409 0.0469
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0355 0.0408
Brugia malayi hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0424 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0118 0.0139
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0347 0.0398
Echinococcus multilocularis protein dispatched 1 0.0049 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Loa Loa (eye worm) hypothetical protein 0.0053 0.0475 0.0544
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0246 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis lamin 0.0028 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Schistosoma mansoni intermediate filament proteins 0.0028 0.0173 0.0204
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0118 0.0118
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0129 0.1405 0.1612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0347 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0662 0.1158
Onchocerca volvulus 0.0024 0.0118 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0071 0.0084
Schistosoma mansoni hypothetical protein 0.0148 0.1639 0.1932
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni nuclear hormone receptor 0.002 0.0071 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Mycobacterium ulcerans pyruvate kinase 0.0068 0.0662 0.075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0402 0.0461
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0118 0.0118
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0347 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0101 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.6051 0.694
Loa Loa (eye worm) hypothetical protein 0.0187 0.2113 0.2423
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1048 0.1202
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0347 0.0347
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0212 0.0243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.1639 0.188
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1591 0.1824
Schistosoma mansoni inositol monophosphatase 0.0038 0.0295 0.0348
Leishmania major hypothetical protein, conserved 0.0037 0.0284 0.4282
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0347 0.0409
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0568 0.8576
Onchocerca volvulus 0.002 0.0071 0.0125
Onchocerca volvulus 0.0028 0.0173 0.0303
Onchocerca volvulus 0.0037 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) MBCTL1 0.0056 0.0507 0.0581
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0101 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0068 0.0662 0.075
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.042 0.0476
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi putative neuropeptide receptor 0.0024 0.0118 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Trichomonas vaginalis esterase, putative 0.0037 0.0284 0.0496
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Echinococcus granulosus lamin dm0 0.0028 0.0173 0.0198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2753 0.3116
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.042 0.0476
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0347 0.0347
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor protein 1 0.0024 0.0118 0.0136
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Echinococcus multilocularis somatostatin receptor 0.0024 0.0118 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0347 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0283 0.0325
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0118 0.0136
Brugia malayi AKH receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0118 0.0118
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0031 0.0208 0.0236
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.108 0.1273
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3493 1
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Onchocerca volvulus 0.0024 0.0118 0.0207
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0284 0.0321
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0284 0.0325
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0071 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0118 0.0136
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0118 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0355 0.0408
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0071 0.0071
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0295 0.0517
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0568 0.067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi G protein-coupled receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0283 0.0283
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Mycobacterium leprae Probable pyruvate kinase PykA 0.0068 0.0662 0.075
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi steroid hormone receptor 0.0043 0.0347 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni nuclear hormone receptor 0.002 0.0071 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Schistosoma mansoni adenoreceptor 0.0024 0.0118 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0347 0.0398
Loa Loa (eye worm) inositol-1 0.0038 0.0295 0.0339
Echinococcus multilocularis protein patched 0.0043 0.0355 0.0355
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0284 0.0321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.042 0.0476
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0347 0.0398
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0118 0.0118
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0355 0.0408
Onchocerca volvulus 0.0148 0.1639 0.2866
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0295 0.0846
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0031 0.0208 0.0236
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Onchocerca volvulus 0.0028 0.0173 0.0303
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0737 0.8835 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni patched 1 0.0043 0.0355 0.0419
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0071 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0347 0.0398
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0118 0.0118
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Echinococcus multilocularis serotonin receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0118 0.0136
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0325
Brugia malayi hypothetical protein 0.0129 0.1405 0.1612
Brugia malayi mbt repeat family protein 0.0049 0.0424 0.0486
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Brugia malayi Pyruvate kinase, muscle isozyme 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi nuclear receptor RXR 0.002 0.0071 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0347 0.0398
Brugia malayi neuropeptide F receptor 0.0024 0.0118 0.0136
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0284 0.2326
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Echinococcus granulosus neuropeptide receptor 0.0024 0.0118 0.0136
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0118 0.0136
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0079 0.009
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0587 0.8864
Brugia malayi pyruvate kinase 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0118 0.0139
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0212 0.0243
Plasmodium vivax vivapain-1 0.0114 0.1219 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2184 0.2505
Echinococcus granulosus orexin receptor type 2 0.0024 0.0118 0.0136
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0347 0.0398
Echinococcus multilocularis geminin 0.0347 0.4073 0.4073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0424 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.01 0.1048 0.1202
Echinococcus granulosus microtubule associated protein 2 0.0708 0.8484 0.973
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0071 0.0082
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1591 0.1591
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor protein 2 0.0024 0.0118 0.0136
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0118 0.0136
Brugia malayi nuclear hormone receptor 0.002 0.0071 0.0082
Chlamydia trachomatis pyruvate kinase 0.0068 0.0662 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0295 0.4461
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0118 0.0139
Brugia malayi conserved hypotetical protein 0.002 0.0071 0.0082
Echinococcus granulosus serotonin receptor 0.0024 0.0118 0.0136
Schistosoma mansoni coup transcription factor 0.0043 0.0347 0.0409
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.8484 0.8484
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0347 0.0398
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Echinococcus granulosus pyruvate kinase 0.0068 0.0662 0.076
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0284 0.4282
Brugia malayi intermediate filament protein 0.0028 0.0173 0.0198
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0284 0.0321
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0118 0.0136
Brugia malayi MH2 domain containing protein 0.0126 0.1365 0.1565
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0118 0.0136
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0347 0.0606
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0118 0.0136
Brugia malayi nuclear receptor NHR-88 0.0043 0.0347 0.0398
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0118 0.0139
Schistosoma mansoni hypothetical protein 0.0037 0.0283 0.0334
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0408
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0002 0.0002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0507 0.0581
Loa Loa (eye worm) hypothetical protein 0.0101 0.1061 0.1216
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni nuclear receptor 0.002 0.0071 0.0084
Schistosoma mansoni hypothetical protein 0.0347 0.4073 0.48
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0347 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0347 0.0409
Loa Loa (eye worm) DR-78 0.002 0.0071 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0482 0.5719 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0173 0.0198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0347 0.0409
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0118 0.0136
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0071 0.0082
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi Melatonin receptor type 1A 0.0024 0.0118 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.042 0.1203
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0118 0.0118
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0295 0.0517
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0284 0.0321
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.1061 0.1216
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0037 0.0283 0.0325
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0037 0.0284 0.0496
Echinococcus multilocularis musashi 0.0028 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0056 0.0507 0.0581
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0118 0.0136
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0071 0.0082
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.027 0.0305
Onchocerca volvulus 0.0024 0.0118 0.0207
Schistosoma mansoni myosin xvIII 0.0024 0.0118 0.0139
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0118 0.0136
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0347 0.0409
Brugia malayi follicle stimulating hormone receptor 0.0726 0.8704 0.9983
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0424 0.0741
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0568 0.0568
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0031 0.0208 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0402 0.0461
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.6051 0.6051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0071 0.0084
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Echinococcus granulosus sex peptide receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0071 0.0071
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2184 0.2184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Onchocerca volvulus 0.0024 0.0118 0.0207
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0118 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Echinococcus granulosus somatostatin receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0347 0.4073 0.48
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0118 0.0136
Echinococcus granulosus neuropeptide s receptor 0.0509 0.6051 0.694
Schistosoma mansoni hypothetical protein 0.0068 0.0661 0.078
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0424 0.0424
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Mycobacterium ulcerans hypothetical protein 0.0037 0.0284 0.0321
Brugia malayi RE15519p 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0727 0.8719 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0101 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0118 0.0118
Onchocerca volvulus 0.002 0.0071 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Brugia malayi CHE-14 protein 0.0043 0.0355 0.0408
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3493 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0068 0.0662 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0424 0.0486
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.027 0.2214
Brugia malayi beta-lactamase 0.0037 0.0284 0.0325
Brugia malayi neuropeptide F receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1617 0.183
Brugia malayi sulfakinin receptor protein 0.0024 0.0118 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0284 0.0325
Onchocerca volvulus Huntingtin homolog 0.0129 0.1405 0.2457
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.042 0.0476
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0662 1
Echinococcus multilocularis serotonin receptor 0.0024 0.0118 0.0118
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0212 0.0243
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.5004 0.5739
Echinococcus granulosus allatostatin A receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi Serotonin receptor 0.0024 0.0118 0.0136
Brugia malayi tailless protein 0.002 0.0071 0.0082
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0726 0.8704 0.9983
Schistosoma mansoni nuclear receptor 0.002 0.0071 0.0084
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0118 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0347 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0347 0.0398
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0071 0.0082
Echinococcus multilocularis lamin dm0 0.0028 0.0173 0.0173
Brugia malayi hypothetical protein 0.0727 0.8719 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0347 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0071 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0402 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0587 0.0692
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0283 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi nuclear receptor NHR-67 0.002 0.0071 0.0082
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0347 0.0347
Trypanosoma brucei pyruvate kinase 1 0.0068 0.0662 1
Schistosoma mansoni pyruvate kinase 0.0035 0.0255 0.0301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi hypothetical protein 0.0155 0.1721 0.1974
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.3493 1
Onchocerca volvulus 0.0482 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Plasmodium falciparum cysteine proteinase falcipain 1 0.0114 0.1219 1
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0031 0.0208 0.0596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0402 0.0402
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0071 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0347 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1365 0.1565
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0118 0.0136
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0118 0.0139
Onchocerca volvulus 0.0024 0.0118 0.0207
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0118 0.0118
Brugia malayi ORL1-like opioid receptor 0.0024 0.0118 0.0136
Brugia malayi G-protein coupled receptor 0.0024 0.0118 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0031 0.0208 0.0236
Plasmodium vivax SET domain protein, putative 0.0061 0.0568 0.466
Echinococcus multilocularis sex peptide receptor 0.0024 0.0118 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0295 0.0517
Mycobacterium tuberculosis Probable conserved exported protein 0.0031 0.0208 0.0236
Onchocerca volvulus 0.0155 0.1721 0.301
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0347 0.0409
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0118 0.0118
Brugia malayi G-protein coupled receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0049 0.042 0.0735
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0347 0.0398
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0187 0.2113 0.2423
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor 0.0024 0.0118 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0071 0.0071
Brugia malayi Pre-SET motif family protein 0.0061 0.0568 0.0652
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0118 0.0136
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0347 0.0398
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi hypothetical protein 0.002 0.0071 0.0082
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0173 0.0198
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0118 0.0136
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0507 0.0581
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0071 0.0082
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0507 0.0507
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0347 0.0347
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0295 0.0295
Brugia malayi nuclear receptor RXR 0.0023 0.0101 0.0116
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0284 0.0321
Mycobacterium tuberculosis Conserved protein 0.0031 0.0208 0.0236
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0507 0.0581
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0347 0.0409
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0118 0.0136
Brugia malayi Esterase D 0.0031 0.0208 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0347 0.0398
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0118 0.0207
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor E75 0.002 0.0071 0.0082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Loa Loa (eye worm) hypothetical protein 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0568 0.0652
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Brugia malayi Pyruvate kinase, M2 isozyme 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.0068 0.0661 0.0759
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0347 0.0606
Brugia malayi hypothetical protein 0.0023 0.0101 0.0116
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0424 0.05
Toxoplasma gondii pyruvate kinase PyK1 0.0068 0.0662 1
Brugia malayi Serotonin receptor 0.0024 0.0118 0.0136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.027 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Echinococcus multilocularis S formylglutathione hydrolase 0.0031 0.0208 0.0208
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.042 0.1203
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.205 0.3584
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0061 0.0568 0.0993
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0118 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.1061 0.3037
Echinococcus multilocularis GPCR, family 2 0.0032 0.0212 0.0212
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0662 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0347 0.0347
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1617 0.183
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0424 0.0486
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0737 0.8835 1
Echinococcus multilocularis survival motor neuron protein 1 0.0727 0.8719 0.8719
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0071 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0118 0.0139
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.042 0.1203
Brugia malayi ecdysteroid receptor 0.0043 0.0347 0.0398
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0347 0.0398
Leishmania major pyruvate kinase 0.0068 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1721 0.1974
Brugia malayi nuclear hormone receptor 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0118 0.0118
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0071 0.0071
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0118 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0118 0.0139
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0118 0.0139
Onchocerca volvulus 0.0043 0.0347 0.0606
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor E75 0.002 0.0071 0.0082
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.042 0.0476
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0507 0.0597
Schistosoma mansoni zinc finger protein 0.002 0.0071 0.0084
Onchocerca volvulus 0.0037 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0587 0.0673
Onchocerca volvulus 0.0049 0.0424 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0347 0.0398
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.8484 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0409 0.0469
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0212 0.0212
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0173 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.042 0.0476
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0118 0.0136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Echinococcus granulosus fmrfamide receptor 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0347 0.0398
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.1061 0.1216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0071 0.0082
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0662 0.1158
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0246 0.0279
Schistosoma mansoni histamine h1 receptor 0.0024 0.0118 0.0139
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0325
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0118 0.0136
Echinococcus granulosus GPCR family 2 0.0032 0.0212 0.0243
Echinococcus granulosus expressed conserved protein 0.0095 0.0986 0.1131
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0118 0.0118
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0297 0.3464 0.4083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0402 0.0402
Brugia malayi GnHR receptor homolog 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.0424 0.0486
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Mycobacterium ulcerans lipase LipD 0.0037 0.0284 0.0321
Brugia malayi mbt repeat family protein 0.0049 0.0424 0.0486
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0347 0.0347
Plasmodium vivax unspecified product 0.0106 0.1127 0.924
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0071 0.0125
Echinococcus granulosus geminin 0.0347 0.4073 0.4671
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0118 0.0118
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0284 0.0321
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0031 0.0208 0.0236
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0347 0.0398
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Mycobacterium ulcerans beta-lactamase 0.0037 0.0284 0.0321
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0071 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0587 0.0692
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0212 0.0243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0347 0.0398
Giardia lamblia Pyruvate kinase 0.0068 0.0662 0.1259
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0118 0.0139
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.6051 0.6051
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0347 0.0398
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0347 0.0398
Echinococcus granulosus survival motor neuron protein 1 0.0727 0.8719 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0587 0.8864
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis pyruvate kinase 0.0068 0.0662 0.0662
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0031 0.0208 0.0236
Echinococcus multilocularis pyruvate kinase 0.0054 0.0486 0.0486
Leishmania major pyruvate kinase 0.0068 0.0662 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0424 0.05
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0409 0.1171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0212 0.0212
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0118 0.0139
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0071 0.0125
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.042 0.0476
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0295 0.0339
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0347 0.0398
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Brugia malayi ecdysone receptor 0.002 0.0071 0.0082
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus lamin 0.0028 0.0173 0.0198
Schistosoma mansoni lamin 0.0028 0.0173 0.0204
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0568 0.0568
Mycobacterium leprae Probable lipase LipE 0.0037 0.0284 0.0321
Brugia malayi Pre-SET motif family protein 0.0423 0.5004 0.5739
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0347 0.0409
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0118 0.0118
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0031 0.0208 0.0236
Loa Loa (eye worm) esterase D 0.0031 0.0208 0.0239
Schistosoma mansoni pyruvate kinase 0.0068 0.0662 0.0781
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0295 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0284 0.0325
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0661 0.0759
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.042 0.0476
Echinococcus multilocularis pyruvate kinase 0.0068 0.0662 0.0662
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0071 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0347 0.0398
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0255 0.2091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1048 0.1202
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0118 0.0136
Plasmodium vivax pyruvate kinase, putative 0.0068 0.0662 0.5434
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0173 0.0198
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0737 0.8835 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Echinococcus granulosus neuropeptide receptor 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0031 0.0208 0.0236
Plasmodium vivax unspecified product 0.0114 0.1219 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Plasmodium falciparum pyruvate kinase 0.0068 0.0662 0.5434
Schistosoma mansoni pyruvate kinase 0.0068 0.0662 0.0781
Schistosoma mansoni lamin 0.0028 0.0173 0.0204
Schistosoma mansoni inositol monophosphatase 0.0038 0.0295 0.0348
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0347 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0334
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Mycobacterium tuberculosis Possible conserved membrane protein 0.0031 0.0208 0.0236
Toxoplasma gondii ABC1 family protein 0.0037 0.0284 0.4282
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0347 0.0398
Onchocerca volvulus Huntingtin homolog 0.0129 0.1405 0.2457
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Echinococcus multilocularis expressed conserved protein 0.0095 0.0986 0.0986
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0191
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0347 0.0409
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0255 0.3849
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0347 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0355 0.0621
Echinococcus granulosus hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus pyruvate kinase 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0295 0.0334
Mycobacterium ulcerans hypothetical protein 0.0049 0.042 0.0476
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0355 0.0355
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0212 0.0243
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Onchocerca volvulus 0.0024 0.0118 0.0207
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0347 0.0398
Brugia malayi nuclear receptor NHR-88 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.3493 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) beta-lactamase 0.0037 0.0284 0.0325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0541 0.062
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0118 0.0207
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni survival motor neuron protein 0.0148 0.1639 0.1932
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0284 0.0284
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1365 0.1565
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.1061 0.1061
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1617 0.183
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0587 0.0587
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0347 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.4282
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0118 0.0118
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0402 0.0461
Onchocerca volvulus 0.0024 0.0118 0.0207

Activities

Activity type Activity value Assay description Source Reference
Max T/C (functional) = 100 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported. T/C >=125 is considered active ChEMBL. 3973905
Max T/C (functional) = 144 In vivo activity against P388 lymphocytic leukemia, and the maximum T/C values were reported. T/C >=125 is considered active ChEMBL. 3973905
OD (functional) = 6.4 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia. ChEMBL. 3973905
OD (functional) = 6.4 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia. ChEMBL. 3973905
OD (functional) = 16 mg kg-1 Optimal dose required for activity against P388 lymphocytic leukemia. ChEMBL. 3973905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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