Detailed information for compound 22218

Basic information

Technical information
  • TDR Targets ID: 22218
  • Name: 2-[5-(4-chlorobenzoyl)-1-methyl-4-methylsulfa nylpyrrol-2-yl]acetic acid
  • MW: 323.795 | Formula: C15H14ClNO3S
  • H donors: 1 H acceptors: 3 LogP: 2.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1cc(n(c1C(=O)c1ccc(cc1)Cl)C)CC(=O)O
  • InChi: 1S/C15H14ClNO3S/c1-17-11(8-13(18)19)7-12(21-2)14(17)15(20)9-3-5-10(16)6-4-9/h3-7H,8H2,1-2H3,(H,18,19)
  • InChiKey: CVXBSTOFIKXCPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-(4-chlorobenzoyl)-1-methyl-4-methylsulfanyl-pyrrol-2-yl]acetic acid
  • 2-[5-[(4-chlorophenyl)-oxomethyl]-1-methyl-4-(methylthio)-2-pyrrolyl]acetic acid
  • 2-[5-(4-chlorophenyl)carbonyl-1-methyl-4-methylsulfanyl-pyrrol-2-yl]ethanoic acid
  • 2-[5-(4-chlorobenzoyl)-1-methyl-4-(methylthio)pyrrol-2-yl]acetic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0137 0.0122
Brugia malayi Dihydrofolate reductase 0.0167 0.0832 0.0861
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.006 0.0063
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0149 0.0155
Schistosoma mansoni hypothetical protein 0.0048 0.0192 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.006 0.0063
Echinococcus granulosus endoplasmin 0.0042 0.0157 0.0162
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0015 0.0015
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0091 0.0094
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0167 0.0832 0.0847
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.006 0.0063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0126 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.006 0.0063
Entamoeba histolytica hypothetical protein 0.0036 0.0126 0.4367
Plasmodium vivax endoplasmin, putative 0.0044 0.0171 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.006 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.006 0.0063
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0157 0.0147
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0106 0.0077
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.006 0.0063
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0064 0.0049
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Toxoplasma gondii heat shock protein HSP90 0.0044 0.0171 0.0157
Loa Loa (eye worm) heat shock protein 90 0.0044 0.0171 0.0178
Loa Loa (eye worm) heat shock protein 75 0.003 0.0091 0.0094
Leishmania major hypothetical protein, conserved 0.0024 0.0064 0.0049
Chlamydia trachomatis dihydrofolate reductase 0.0167 0.0832 0.5
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0859 0.4558 0.455
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0078 0.008
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0015 0.0015
Schistosoma mansoni heat shock protein 0.0044 0.0171 0.0178
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0131 0.0136
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.006 0.0063
Mycobacterium tuberculosis Hypothetical protein 0.0859 0.4558 0.4712
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.187 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0075 0.0078
Mycobacterium ulcerans thymidylate synthase 0.1806 0.9656 1
Schistosoma mansoni coup transcription factor 0.0024 0.006 0.0063
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0167 0.0832 0.0711
Brugia malayi hypothetical protein 0.0024 0.0064 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.006 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.006 0.0063
Plasmodium falciparum heat shock protein 90, putative 0.0168 0.0838 0.0825
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.006 0.0063
Brugia malayi isocitrate dehydrogenase 0.0015 0.0015 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0015 0.0015
Echinococcus multilocularis musashi 0.0027 0.0078 0.008
Schistosoma mansoni heat shock protein 0.003 0.0091 0.0094
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.006 0.0063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0192 0.0199
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0064 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0237 0.1207 0.125
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.006 0.0063
Toxoplasma gondii heat shock protein 90, putative 0.0044 0.0171 0.0157
Onchocerca volvulus 0.0027 0.0078 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0192 0.0199
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0131 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0064 0.0049
Giardia lamblia Grp94/Hsp90 0.0042 0.0157 0.5748
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0015 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.006 0.0063
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0137 0.0142
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Brugia malayi nuclear hormone receptor 0.0024 0.006 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0126 0.0131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.006 0.0063
Schistosoma mansoni hypothetical protein 0.0033 0.011 0.0114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.006 0.0063
Brugia malayi Hsp90 protein 0.003 0.0091 0.0094
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0091 0.0032
Brugia malayi heat shock protein 90 0.0044 0.0171 0.0178
Echinococcus multilocularis thymidylate synthase 0.1806 0.9656 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.006 0.0063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0015 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0015 0.0015
Onchocerca volvulus 0.1806 0.9656 1
Onchocerca volvulus 0.005 0.0199 0.0144
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0171 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.006 0.0063
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0199 0.0206
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.006 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.006 0.0063
Loa Loa (eye worm) endoplasmin 0.0044 0.0171 0.0178
Loa Loa (eye worm) dihydrofolate reductase 0.0167 0.0832 0.0861
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Schistosoma mansoni hypothetical protein 0.0334 0.173 0.1791
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0137 0.0146
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1806 0.9656 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Schistosoma mansoni hypothetical protein 0.0036 0.0126 0.0131
Brugia malayi hypothetical protein 0.0016 0.0017 0.0018
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0091 0.0077
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0015
Brugia malayi nuclear receptor NHR-88 0.0024 0.006 0.0063
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0064 0.0049
Echinococcus multilocularis geminin 0.0334 0.173 0.1791
Schistosoma mansoni thyroid hormone receptor 0.0024 0.006 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.4558 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.006 0.0063
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.006 0.0063
Onchocerca volvulus 0.0048 0.0192 0.0137
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0171 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.006 0.0063
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.187 1 1
Schistosoma mansoni heat shock protein 0.0044 0.0171 0.0178
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.006 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.006 0.0063
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.187 1 1
Brugia malayi ecdysteroid receptor 0.0024 0.006 0.0063
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.006 0.0063
Echinococcus multilocularis tumor protein p63 0.0338 0.1753 0.1816
Brugia malayi hypothetical protein 0.0036 0.0126 0.0131
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.006 0.0063
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0118 0.0104
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.006 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.006 0.0063
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.001 0.0011
Plasmodium vivax heat shock protein, putative 0.0168 0.0838 0.0825
Entamoeba histolytica hypothetical protein 0.0036 0.0126 0.4367
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0149 0.0155
Plasmodium falciparum heat shock protein 90 0.0044 0.0171 0.0157
Echinococcus granulosus tumor protein p63 0.0338 0.1753 0.1816
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.006 0.0063
Entamoeba histolytica hypothetical protein 0.0036 0.0126 0.4367
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Echinococcus granulosus heat shock protein 0.0044 0.0171 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0024 0.006 0.0063
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0157 0.019
Echinococcus multilocularis lamin dm0 0.0027 0.0078 0.008
Treponema pallidum heat shock protein 90 0.0042 0.0157 0.5
Schistosoma mansoni dihydrofolate reductase 0.0167 0.0832 0.0861
Echinococcus granulosus lamin 0.0027 0.0078 0.008
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0064 0.0049
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0015 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0064 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1207 0.125
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.006 0.0063
Trypanosoma brucei Heat shock protein 83, putative 0.0044 0.0171 0.0157
Onchocerca volvulus 0.0027 0.0078 0.0018
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.187 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0126 0.4367
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0071 0.0057
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0171 0.0223
Schistosoma mansoni lamin 0.0027 0.0078 0.008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.006 0.0063
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.006 0.0063
Echinococcus granulosus intermediate filament protein 0.0027 0.0078 0.008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Echinococcus multilocularis heat shock protein 0.0044 0.0171 0.0178
Schistosoma mansoni endoplasmin 0.0044 0.0171 0.0178
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0131 0.0136
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0131 0.0136
Echinococcus granulosus heat shock protein 90 0.0038 0.0137 0.0142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.1193 0.1236
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0157 0.5
Schistosoma mansoni thyroid hormone receptor 0.0024 0.006 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.006 0.0063
Echinococcus multilocularis dihydrofolate reductase 0.0167 0.0832 0.0861
Toxoplasma gondii Hsp90 domain-containing protein 0.0168 0.0838 0.0825
Echinococcus multilocularis heat shock protein 90 0.0038 0.0137 0.0142
Echinococcus multilocularis GPCR, family 2 0.0015 0.0015 0.0015
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0078 0.008
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0091 0.0077
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0171 0.0157
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0157 0.019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Loa Loa (eye worm) thymidylate synthase 0.1806 0.9656 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0192 0.0199
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.006 0.0063
Echinococcus multilocularis heat shock protein 90 0.0044 0.0171 0.0178
Brugia malayi thymidylate synthase 0.1806 0.9656 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0118 0.0104
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0064 0.0049
Trypanosoma cruzi heat shock protein, putative 0.003 0.0091 0.0077
Echinococcus granulosus geminin 0.0334 0.173 0.1791
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.006 0.0063
Brugia malayi hypothetical protein 0.0237 0.1207 0.125
Echinococcus granulosus thymidylate synthase 0.1806 0.9656 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0078 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.006 0.0063
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0171 0.0157
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0171 0.0157
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0171 0.0157
Plasmodium vivax heat shock protein 90, putative 0.003 0.0091 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.006 0.0063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.006 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.006 0.0063
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0167 0.0832 0.0711
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.011 0.0114
Echinococcus granulosus dihydrofolate reductase 0.0167 0.0832 0.0861
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.006 0.0063
Brugia malayi Endoplasmin precursor 0.0044 0.0171 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0032 0.0018
Echinococcus granulosus GPCR family 2 0.0015 0.0015 0.0015
Echinococcus granulosus lamin dm0 0.0027 0.0078 0.008
Schistosoma mansoni lamin 0.0027 0.0078 0.008
Echinococcus granulosus heat shock protein 90 0.0044 0.0171 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.008
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0106 0.0077
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0015 0.0015
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0137 0.0122
Brugia malayi follicle stimulating hormone receptor 0.0234 0.1193 0.1236
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0192 0.0199
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi steroid hormone receptor 0.0024 0.006 0.0063
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.006 0.0063
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.187 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi Heat shock protein 83, putative 0.0044 0.0171 0.0157
Brugia malayi dihydrofolate reductase family protein 0.0167 0.0832 0.0861
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0171 1
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0171 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0015 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.006 0.0063
Schistosoma mansoni endoplasmin 0.0044 0.0171 0.0178
Trypanosoma brucei heat shock protein, putative 0.0044 0.0171 0.0157
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1806 0.9656 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.006 0.0063
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0171 0.0157
Leishmania major heat shock protein, putative 0.003 0.0091 0.0077
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.006 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0192 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.006 0.0063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0015 0.0015
Echinococcus multilocularis endoplasmin 0.0042 0.0157 0.0162
Loa Loa (eye worm) hypothetical protein 0.005 0.0199 0.0206
Brugia malayi intermediate filament protein 0.0027 0.0078 0.008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0015 0.0015
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1207 0.125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.006 0.0063
Echinococcus multilocularis lamin 0.0027 0.0078 0.008
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.006 0.0063
Plasmodium falciparum endoplasmin, putative 0.0032 0.0106 0.0091
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0126 0.0131
Leishmania major heat shock protein 83-1 0.0044 0.0171 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0063
Brugia malayi hypothetical protein 0.0859 0.4558 0.4721
Schistosoma mansoni nuclear hormone receptor 0.0024 0.006 0.0063
Schistosoma mansoni intermediate filament proteins 0.0027 0.0078 0.008
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Schistosoma mansoni survival motor neuron protein 0.0048 0.0192 0.0199
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0091 0.0094
Plasmodium vivax heat shock protein 86, putative 0.0044 0.0171 0.0157
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0334 0.173 0.1791
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1806 0.9656 1

Activities

Activity type Activity value Assay description Source Reference
ED30 (functional) = 1.5 mg kg-1 Antiinflammatory activity assessed by inhibition of carrageenan-induced edema in rats at a dose of 15 mg/kg ChEMBL. 2724294
ED50 (functional) = 56 mg kg-1 Analgesic activity of the compound was assessed from the ability of the compound to inhibit phenylquinone-induced writhing in mouse at a dose of 70 mg/kg ChEMBL. 2724294
ED50 (functional) = 56 mg kg-1 Analgesic activity of the compound was assessed from the ability of the compound to inhibit phenylquinone-induced writhing in mouse at a dose of 70 mg/kg ChEMBL. 2724294

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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