Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Androgen Receptor | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.5 | 0.5 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Biological Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.