Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin (5-HT) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1176 | 0.1176 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0114 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0114 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0114 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0114 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0027 | 0.1176 | 0.1176 |
Schistosoma mansoni | immunophilin | 0.0114 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0027 | 0.1176 | 0.1176 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.1176 | 0.1176 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1176 | 0.1176 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0114 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0027 | 0.1176 | 0.1176 |
Onchocerca volvulus | Arrow homolog | 0.0027 | 0.1176 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0114 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0114 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0114 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0027 | 0.1176 | 0.1176 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0027 | 0.1176 | 0.1176 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0027 | 0.1176 | 0.1176 |
Schistosoma mansoni | immunophilin | 0.0098 | 0.8404 | 0.8404 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1176 | 0.1176 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0098 | 0.8404 | 0.8404 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0114 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0114 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0114 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0114 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0114 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0114 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0027 | 0.1176 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0027 | 0.1176 | 0.1176 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1176 | 0.1176 |
Echinococcus multilocularis | laminin | 0.0027 | 0.1176 | 0.1176 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0114 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0016 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0114 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.1176 | 0.1176 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0114 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0114 | 1 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0016 | 0 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1176 | 0.1176 |
Echinococcus granulosus | laminin | 0.0027 | 0.1176 | 0.1176 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0114 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0114 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0114 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0027 | 0.1176 | 0.1176 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0027 | 0.1176 | 0.1176 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0027 | 0.1176 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0098 | 0.8404 | 0.8404 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0114 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.8404 | 0.8404 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0114 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 6.14 | Affinity for 5-hydroxytryptamine receptor was determined using male Dawley rat fundus preparation | ChEMBL. | 7069716 |
pA2 (binding) | = 6.14 | Affinity for 5-hydroxytryptamine receptor was determined using male Dawley rat fundus preparation | ChEMBL. | 7069716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.