Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2028 | 0.5895 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2028 | 0.5895 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.0726 | 0.0726 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0543 | 0.0543 |
Onchocerca volvulus | 0.0543 | 0.1493 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0296 | 0.0296 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2028 | 0.5895 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0083 | 0.0128 | 0.0128 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.043 | 0.0423 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0053 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0184 | 0.0184 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2028 | 0.5895 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3413 | 1 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0713 | 0.0713 |
Echinococcus granulosus | geminin | 0.0164 | 0.0368 | 0.0368 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0053 | 0.0046 |
Echinococcus multilocularis | thymidylate synthase | 0.0543 | 0.1493 | 0.1493 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.0302 | 0.0302 |
Echinococcus granulosus | dihydrofolate reductase | 0.3413 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.001 | 0.001 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0053 | 0.0053 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0368 | 0.0368 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3413 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3413 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3413 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3413 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3413 | 1 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0043 | 0.001 | 0.001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0259 | 0.0649 | 0.5 |
Brugia malayi | hypothetical protein | 0.0259 | 0.0649 | 0.0642 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.043 | 0.043 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.1004 | 0.1004 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2028 | 0.5895 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0296 | 0.029 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.0124 | 0.0124 |
Brugia malayi | thymidylate synthase | 0.0543 | 0.1493 | 0.1487 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.0124 | 0.0117 |
Echinococcus granulosus | integrin alpha ps | 0.0083 | 0.0128 | 0.0128 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.1004 | 0.0997 |
Echinococcus granulosus | thymidylate synthase | 0.0543 | 0.1493 | 0.1493 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0259 | 0.0649 | 0.109 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0042 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0053 | 0.0053 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0543 | 0.1493 | 0.1493 |
Mycobacterium ulcerans | thymidylate synthase | 0.0543 | 0.1493 | 0.1487 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0368 | 0.0368 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0543 | 0.1493 | 0.0903 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0042 | 0.0007 | 0.0007 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | thymidylate synthase | 0.0543 | 0.1493 | 0.1493 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0312 | 0.0312 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.0302 | 0.0302 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0368 | 0.0368 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0713 | 0.0713 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0042 | 0.0007 | 0.0007 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2028 | 0.5895 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3413 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogen | ChEMBL. | 10633036 |
IC50 (binding) | = 18 nM | Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogen | ChEMBL. | 10633036 |
IC50 (functional) | = 190 nM | Inhibition of platelet aggregation in human gel-purified platelets containing fibrinogen (GPP+Fg). | ChEMBL. | 10633036 |
IC50 (functional) | = 190 nM | Inhibition of platelet aggregation in human gel-purified platelets containing fibrinogen (GPP+Fg). | ChEMBL. | 10633036 |
IC50 (functional) | = 350 nM | Inhibition of platelet aggregation in human platelet rich plasma (PRP) | ChEMBL. | 10633036 |
IC50 (functional) | = 350 nM | Inhibition of platelet aggregation in human platelet rich plasma (PRP) | ChEMBL. | 10633036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.