Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0078 | 0.2609 | 0.4014 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0152 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.6499 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Dopamine receptor | 0.0078 | 0.2609 | 0.4014 |
Onchocerca volvulus | 0.0117 | 0.6499 | 1 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0078 | 0.2609 | 0.4014 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0108 | 0.5625 | 0.7753 |
Brugia malayi | GnHR receptor homolog | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Melatonin receptor type 1A | 0.0078 | 0.2609 | 0.4014 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0108 | 0.5625 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0108 | 0.5625 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0078 | 0.2609 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.6499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.6499 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.6499 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.6499 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0152 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0078 | 0.2609 | 0.4014 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0152 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0152 | 1 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Mycobacterium ulcerans | thymidylate synthase | 0.0108 | 0.5625 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Dopamine receptor protein 2 | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | G protein-coupled receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | neuropeptide F receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | G-protein coupled receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | thymidylate synthase | 0.0108 | 0.5625 | 0.8655 |
Brugia malayi | RE15519p | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Serotonin receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | ORL1-like opioid receptor | 0.0078 | 0.2609 | 0.4014 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0108 | 0.5625 | 0.7753 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | neuropeptide F receptor | 0.0078 | 0.2609 | 0.4014 |
Onchocerca volvulus | 0.0106 | 0.5467 | 0.7347 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | follicle stimulating hormone receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Dopamine receptor protein 1 | 0.0078 | 0.2609 | 0.4014 |
Echinococcus multilocularis | thymidylate synthase | 0.0108 | 0.5625 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0108 | 0.5625 | 0.7753 |
Brugia malayi | putative neuropeptide receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | larval opioid receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | Serotonin receptor | 0.0078 | 0.2609 | 0.4014 |
Echinococcus granulosus | thymidylate synthase | 0.0108 | 0.5625 | 1 |
Brugia malayi | AKH receptor | 0.0078 | 0.2609 | 0.4014 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2609 | 0.4014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.1 nM | Binding affinity against Coagulation factor X in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 3.1 nM | Binding affinity against Coagulation factor X in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 69 nM | Binding affinity against trypsin in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 69 nM | Binding affinity against trypsin in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.