Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Rattus norvegicus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.36 nM | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | ChEMBL. | 27309570 |
IC50 (binding) | = 2 nM | Inhibitory concentration against rat brain acetylcholinesterase AChE | ChEMBL. | 9767635 |
IC50 (binding) | = 2 nM | Inhibitory concentration against rat brain acetylcholinesterase AChE | ChEMBL. | 9767635 |
IC50 (binding) | = 13 nM | Inhibition of rat acetylcholinesterase (AChE) | ChEMBL. | 9767635 |
IC50 (binding) | = 13 nM | Inhibition of rat acetylcholinesterase (AChE) | ChEMBL. | 9767635 |
IC50 (binding) | = 28.5 nM | Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by scintillation counting method | ChEMBL. | 27309570 |
IC50 (binding) | = 37.4 nM | Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by substrate addition by Ellman's method | ChEMBL. | 27309570 |
IC50 (binding) | = 65 nM | Inhibition of isolated Butyrylcholinesterase (BuChE ) | ChEMBL. | 9767635 |
IC50 (binding) | = 65 nM | Inhibition of isolated Butyrylcholinesterase (BuChE ) | ChEMBL. | 9767635 |
IC50 (binding) | = 161.4 nM | Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting method | ChEMBL. | 27309570 |
IC50 (binding) | = 0.17 uM | Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measured after 30 mins | ChEMBL. | 24900454 |
IC50 (binding) | = 0.62 uM | Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 mins | ChEMBL. | 24900454 |
K (binding) | = 0.238 /min | Inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme carbamoylation rate constant using acetylthiocholine iodide as substrate incubated for 15 to 120 mins by stopped time assay | ChEMBL. | 27309570 |
K (binding) | = 11.1 /min | Inhibition of human serum BuChE assessed as enzyme carbamoylation rate constant using butyrylthiocholine iodide as substrate incubated for 1 to 30 mins by stopped time assay | ChEMBL. | 27309570 |
Ratio (binding) | = 5 | It is the ratio of IC50 for butyrl cholinesterase (BuChE ) to that of acetylcholinesterase (AChE) | ChEMBL. | 9767635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.