Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FKBP5 protein | 0.018 | 0.4862 | 0.4862 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.018 | 0.4862 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0296 | 1 | 1 |
Onchocerca volvulus | 0.0263 | 0.8539 | 0.8539 | |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.018 | 0.4862 | 0.4862 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0296 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.018 | 0.4862 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.018 | 0.4862 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.018 | 0.4862 | 0.5 |
Schistosoma mansoni | immunophilin | 0.018 | 0.4862 | 0.4862 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.018 | 0.4862 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.018 | 0.4862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.3765 | 0.3765 |
Schistosoma mansoni | immunophilin | 0.018 | 0.4862 | 0.4862 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.018 | 0.4862 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.018 | 0.4862 | 0.4862 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.018 | 0.4862 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0155 | 0.3765 | 0.7745 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.018 | 0.4862 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0155 | 0.3765 | 0.7745 |
Echinococcus multilocularis | fk506 binding protein | 0.018 | 0.4862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.018 | 0.4862 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.018 | 0.4862 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.018 | 0.4862 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.018 | 0.4862 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.018 | 0.4862 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.007 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.018 | 0.4862 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.018 | 0.4862 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.018 | 0.4862 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0155 | 0.3765 | 0.3765 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.018 | 0.4862 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.018 | 0.4862 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.018 | 0.4862 | 0.4862 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.018 | 0.4862 | 1 |
Onchocerca volvulus | 0.0296 | 1 | 1 | |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.018 | 0.4862 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.018 | 0.4862 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.018 | 0.4862 | 0.4862 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.018 | 0.4862 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.6 uM | Effective concentration of compound with DFMO tested in vitro for ability to inhibit polyamine transport and growth of MDA-MB-231 breast carcinoma cell line | ChEMBL. | 11738568 |
EC50 (functional) | = 1.6 uM | Effective concentration of compound with DFMO tested in vitro for ability to inhibit polyamine transport and growth of MDA-MB-231 breast carcinoma cell line | ChEMBL. | 11738568 |
Ki (binding) | = 0.06 uM | Inhibition of SPD uptake by polyamine transporter of MDA-MB-231 breast carcinoma cells | ChEMBL. | 11738568 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11738568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.