Detailed information for compound 222513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.124 | Formula: C33H37ClN4O5
  • H donors: 3 H acceptors: 4 LogP: 3.81 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@](C(=O)N1C[C@@H](C[C@@H]1C(=O)O)c1ccc(cc1)Cl)(Cc1c[nH]c2c1cccc2)C)ON1[C@@H]2C[C@@H]3C[C@H]1C[C@H](C2)C3
  • InChi: 1S/C33H37ClN4O5/c1-33(16-23-17-35-28-5-3-2-4-27(23)28,36-32(42)43-38-25-11-19-10-20(13-25)14-26(38)12-19)31(41)37-18-22(15-29(37)30(39)40)21-6-8-24(34)9-7-21/h2-9,17,19-20,22,25-26,29,35H,10-16,18H2,1H3,(H,36,42)(H,39,40)/t19-,20+,22-,25-,26+,29-,33-/m1/s1
  • InChiKey: FCOZCLZQROEVPT-ONFOHCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholecystokinin B receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 0.0271 0.6401 0.9133
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0193 0.0143
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2462 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0206 0.0241
Echinococcus granulosus zinc finger protein 0.0021 0.0241 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0471 0.3872
Schistosoma mansoni lamin 0.0027 0.039 0.0294
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2462 1
Onchocerca volvulus 0.0029 0.0455 0.0816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0597 0.0504
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0706 0.0614
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0155 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0156 0.0106
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0193 0.0275
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.014 0.009
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0706 0.0659
Echinococcus multilocularis zinc finger protein 0.0021 0.0241 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0706 0.0614
Toxoplasma gondii hypothetical protein 0.0026 0.0384 0.1769
Onchocerca volvulus 0.0035 0.0597 0.1259
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0955 0.557
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0471 0.2352
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0156 0.0106
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0248 0.0151
Brugia malayi nuclear hormone receptor 0.0019 0.0193 0.0275
Brugia malayi RNA recognition motif domain containing protein 0.0188 0.4358 0.6222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0206 0.0458
Brugia malayi nuclear receptor NHR-88 0.0019 0.0193 0.0275
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Loa Loa (eye worm) hypothetical protein 0.0013 0.0051 0.0017
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2462 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0206 0.0295
Trichomonas vaginalis esterase, putative 0.0035 0.0597 0.0651
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0193 0.0402
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.1452 0.1409
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0206 0.0157
Brugia malayi hypothetical protein 0.0032 0.0522 0.0746
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0206 0.0458
Schistosoma mansoni hypothetical protein 0.0168 0.3867 0.3806
Loa Loa (eye worm) hypothetical protein 0.0026 0.0378 0.0487
Mycobacterium ulcerans lipase LipD 0.0035 0.0597 0.0651
Brugia malayi MAP kinase sur-1 0.005 0.0977 0.1395
Brugia malayi hypothetical protein 0.0149 0.3406 0.4863
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0706 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Mycobacterium ulcerans beta-lactamase 0.0035 0.0597 0.0651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0282 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0706 0.0659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0193 0.0402
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0977 0.0931
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0706 0.0659
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0152 0.0224
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2462 0.2424
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Trichomonas vaginalis rotamase, putative 0.0034 0.0573 0.0611
Schistosoma mansoni tar DNA-binding protein 0.0188 0.4358 0.4302
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.03
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0156 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0295 0.7005 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0977 0.1262
Echinococcus multilocularis lamin dm0 0.0027 0.039 0.0341
Loa Loa (eye worm) latrophilin receptor protein 2 0.0093 0.2035 0.2865
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0706 0.0659
Schistosoma mansoni zinc finger protein 0.0019 0.0193 0.0096
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0206 0.0157
Onchocerca volvulus 0.0039 0.0706 0.1598
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0706 0.0659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0977 0.0931
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0977 0.3717
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0548 0.2861
Schistosoma mansoni tar DNA-binding protein 0.0188 0.4358 0.4302
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0471 0.2352
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0597 0.0853
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0471 0.1175
Brugia malayi beta-lactamase family protein 0.0035 0.0597 0.0853
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0471 0.0448
Schistosoma mansoni hypothetical protein 0.0093 0.2035 0.1956
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0597 0.0549
Schistosoma mansoni bromodomain containing protein 0.0063 0.128 0.1194
Schistosoma mansoni tar DNA-binding protein 0.0188 0.4358 0.4302
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0977 0.3717
Schistosoma mansoni hypothetical protein 0.0168 0.3867 0.3806
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0597 0.0934
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0977 0.3717
Schistosoma mansoni rotamase 0.0034 0.0573 0.0479
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0193 0.0096
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0193 0.0591
Echinococcus multilocularis pyruvate kinase 0.0033 0.0548 0.05
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.1195 0.115
Loa Loa (eye worm) hypothetical protein 0.0077 0.162 0.227
Loa Loa (eye worm) hypothetical protein 0.0039 0.0703 0.0954
Brugia malayi hypothetical protein 0.005 0.0955 0.1363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0706 0.0659
Brugia malayi nuclear receptor RXR 0.0021 0.0248 0.0354
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0548 0.1105
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0548 0.0837
Loa Loa (eye worm) TAR-binding protein 0.0188 0.4358 0.6201
Brugia malayi steroid hormone receptor 0.0039 0.0706 0.1008
Brugia malayi hypothetical protein 0.0021 0.0248 0.0354
Schistosoma mansoni DNA polymerase eta 0.0019 0.0193 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0706 0.1008
Brugia malayi latrophilin 2 splice variant baaae 0.0202 0.4704 0.6716
Brugia malayi PHD-finger family protein 0.0026 0.0368 0.0525
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0597 0.0549
Schistosoma mansoni nuclear receptor 0.0019 0.0193 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0193 0.0143
Leishmania major hypothetical protein, conserved 0.005 0.0955 0.3622
Schistosoma mansoni transcription factor LCR-F1 0.007 0.1452 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0573 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0706 0.1008
Schistosoma mansoni hypothetical protein 0.0202 0.4704 0.4652
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0193 0.0591
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0248 0.0198
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0206 0.066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Trypanosoma brucei protein kinase, putative 0.005 0.0977 0.384
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0193 0.0276
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0118 0.0085
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2462 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0553 0.1585
Echinococcus multilocularis pyruvate kinase 0.0017 0.0152 0.0102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0206 0.0021
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0553 0.2895
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0206 0.0587
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0706 0.0659
Echinococcus granulosus dna polymerase kappa 0.0019 0.0193 0.0143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0206 0.0587
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0597 0.0802
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0706 0.0659
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0193 0.0143
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0193 0.0096
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0553 0.1923
Loa Loa (eye worm) hypothetical protein 0.0033 0.0548 0.0731
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0548 0.2061
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0206 0.0458
Onchocerca volvulus 0.0149 0.3406 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0193 0.0143
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0977 0.3717
Loa Loa (eye worm) hypothetical protein 0.0233 0.5481 0.7813
Entamoeba histolytica hypothetical protein 0.007 0.1452 0.5548
Schistosoma mansoni cpg binding protein 0.0033 0.0542 0.0448
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0193 0.0143
Toxoplasma gondii exonuclease III APE 0.0019 0.0206 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0706 0.1008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0471 0.2352
Schistosoma mansoni hypothetical protein 0.0048 0.0907 0.0816
Toxoplasma gondii ABC1 family protein 0.0035 0.0597 0.319
Mycobacterium ulcerans hypothetical protein 0.0035 0.0597 0.0651
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0193 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0188 0.4358 0.4302
Mycobacterium tuberculosis Conserved protein 0.0035 0.0597 0.0934
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0302 0.0378
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0548 0.2061
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0597 0.0651
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0977 0.3717
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0706 0.1008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0706 0.1008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0118 0.0068
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0193 0.0143
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2462 0.3656
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0706 0.1008
Echinococcus granulosus lamin 0.0027 0.039 0.0341
Trypanosoma brucei unspecified product 0.0019 0.0193 0.0591
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0206 0.0057
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2462 0.2388
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0193 0.0275
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0193 0.0275
Schistosoma mansoni pyruvate kinase 0.0017 0.0152 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0193 0.0402
Brugia malayi intermediate filament protein 0.0027 0.039 0.0556
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0193 0.0143
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Entamoeba histolytica hypothetical protein 0.007 0.1452 0.5548
Echinococcus multilocularis pyruvate kinase 0.0033 0.0548 0.05
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0977 0.1262
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0312 0.0216
Loa Loa (eye worm) hypothetical protein 0.005 0.0955 0.1315
Leishmania major DNA polymerase kappa, putative 0.0019 0.0193 0.0402
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0548 0.0571
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0706 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0548 0.1105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Echinococcus granulosus pyruvate kinase 0.0033 0.0548 0.05
Onchocerca volvulus 0.0048 0.0907 0.2221
Loa Loa (eye worm) hypothetical protein 0.0043 0.079 0.1078
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Brugia malayi glutaminase DH11.1 0.0271 0.6401 0.9138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0118 0.0085
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 1
Brugia malayi 6-phosphofructokinase 0.0111 0.2462 0.3516
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0597 0.319
Brugia malayi beta-lactamase family protein 0.0035 0.0597 0.0853
Brugia malayi Bromodomain containing protein 0.0037 0.0645 0.0921
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0597 0.0651
Echinococcus multilocularis lamin 0.0027 0.039 0.0341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2462 0.348
Echinococcus multilocularis GPCR, family 2 0.0093 0.2035 0.1994
Brugia malayi Bromodomain containing protein 0.0074 0.1559 0.2226
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0553 0.1923
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2462 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.039 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0597 0.2111
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0118 0.0114
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.014 0.0042
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0597 0.1026
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0977 1
Brugia malayi tailless protein 0.0019 0.0193 0.0275
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0597 0.0934
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2462 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0248 0.0354
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.014 0.0042
Chlamydia trachomatis pyruvate kinase 0.0033 0.0548 0.0666
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0706 0.1008
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2659 0.3761
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0706 0.0614
Brugia malayi Calcitonin receptor-like protein seb-1 0.0295 0.7005 1
Echinococcus granulosus tar DNA binding protein 0.0188 0.4358 0.4329
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0706 0.0958
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0597 0.2266
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0193 0.0143
Schistosoma mansoni coup transcription factor 0.0039 0.0706 0.0614
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2462 1
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0706 0.1008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0085 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0118 0.028
Echinococcus granulosus intermediate filament protein 0.0027 0.039 0.0341
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0907 0.1294
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0118 0.028
Onchocerca volvulus 0.0027 0.039 0.0613
Schistosoma mansoni hypothetical protein 0.007 0.1452 0.1367
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0206 0.0645
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0706 0.0958
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0188 0.4358 0.6201
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0589 0.0541
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0977 0.1262
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.1195 0.115
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0193 0.0143
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2462 0.2388
Leishmania major hypothetical protein, conserved 0.0035 0.0597 0.2111
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0118 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0706 0.1598
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0548 0.0789
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0193 0.0143
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0977 0.5719
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.097 0.0924
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0597 0.0651
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0312 0.0262
Onchocerca volvulus 0.0027 0.039 0.0613
Echinococcus granulosus cpg binding protein 0.0033 0.0542 0.0494
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0471 0.2352
Schistosoma mansoni pyruvate kinase 0.0033 0.0548 0.0454
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0597 0.0651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.1452 0.1409
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0548 0.0782
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0152 0.0224
Schistosoma mansoni hypothetical protein 0.0093 0.2035 0.1956
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0706 0.0659
Brugia malayi isocitrate dehydrogenase 0.0016 0.0118 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0706 0.1008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.03
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0706 0.0614
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0471 0.2352
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.162 0.1537
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0193 0.0591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0706 0.0958
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0955 0.3622
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2462 0.3656
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0597 0.0934
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0706 0.0958
Brugia malayi TAR-binding protein 0.0188 0.4358 0.6222
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0597 0.0934
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0193 0.0146
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0193 0.0143
Brugia malayi Probable ClpP-like protease 0.0077 0.162 0.2313
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0706 0.1008
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0977 0.0887
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.5481 0.5458
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Brugia malayi hypothetical protein 0.007 0.1452 0.2073
Echinococcus multilocularis pyruvate kinase 0.0026 0.0377 0.0327
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0193 0.0221
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0573 0.0818
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0706 0.0659
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0977 0.1347
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2462 0.348
Brugia malayi nuclear receptor NHR-88 0.0039 0.0706 0.1008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Schistosoma mansoni glutaminase 0.0271 0.6401 0.6365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0597 0.0504
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0706 0.0659
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0907 0.0816
Giardia lamblia DINP protein human, muc B family 0.0019 0.0193 0.0502
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0706 0.0659
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0193 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0548 0.0731
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0193 0.0275
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 0.2298
Loa Loa (eye worm) DR-78 0.0019 0.0193 0.0221
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2462 0.3656
Leishmania major pyruvate kinase 0.0033 0.0548 0.1902
Echinococcus granulosus expressed protein 0.0034 0.0573 0.0525
Schistosoma mansoni hypothetical protein 0.0093 0.2035 0.1956
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0118 0.0068
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0312 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0597 0.0651
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0193 0.0146
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0193 0.0275
Echinococcus multilocularis cpg binding protein 0.0033 0.0542 0.0494
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0225 0.0268
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0955 0.557
Schistosoma mansoni lamin 0.0027 0.039 0.0294
Trichomonas vaginalis rotamase, putative 0.0033 0.0553 0.0579
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0548 0.2861
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.162 0.5946
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0597 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0706 0.0958
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0193 0.0143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0193 0.0143
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2462 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2659 0.3761
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0384 0.1769
Mycobacterium tuberculosis Conserved protein 0.0035 0.0597 0.0934
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 0.2298
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.162 0.1577
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0597 0.0934
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0706 0.0614
Loa Loa (eye worm) hypothetical protein 0.0295 0.7005 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0548 0.05
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0706 0.0614
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0193 0.0276
Brugia malayi conserved hypotetical protein 0.0019 0.0193 0.0275
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.162 0.1577
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0248 0.0354
Brugia malayi hypothetical protein 0.0021 0.0248 0.0354
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0152 0.0224
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0548 0.0571
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0706 0.1598
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 0.6265
Brugia malayi beta-lactamase 0.0035 0.0597 0.0853
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2462 0.3656
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0093 0.2035 0.1994
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0955 0.557
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0118 0.0068
Schistosoma mansoni nuclear receptor 0.0019 0.0193 0.0096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0706 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2462 0.457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0706 0.0958
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0295 0.7005 1
Echinococcus granulosus GPCR family 2 0.0093 0.2035 0.1994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0706 0.1008
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.5481 0.5458
Trichomonas vaginalis glutaminase, putative 0.0271 0.6401 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0093 0.2035 0.1994
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0706 0.0614
Brugia malayi ecdysone receptor 0.0019 0.0193 0.0275
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0193 0.0221
Echinococcus multilocularis tar DNA binding protein 0.0188 0.4358 0.4329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0706 0.0659
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0553 0.2082
Schistosoma mansoni hypothetical protein 0.002 0.0225 0.0128
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.097 0.2821
Schistosoma mansoni hypothetical protein 0.0417 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0706 0.1008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0597 0.0651
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0118 0.0068
Plasmodium falciparum pyruvate kinase 0.0033 0.0548 0.2861
Loa Loa (eye worm) beta-lactamase 0.0035 0.0597 0.0802
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0553 0.1923
Echinococcus granulosus peptidase Clp S14 family 0.005 0.097 0.0924
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0548 0.1902
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0706 0.0614
Schistosoma mansoni cpg binding protein 0.0033 0.0542 0.0448
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Leishmania major pyruvate kinase 0.0033 0.0548 0.1902
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0193 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0188 0.4358 0.4302
Loa Loa (eye worm) hypothetical protein 0.0068 0.1416 0.1978
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0955 0.3748
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0093 0.2035 0.2905
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0248 0.03
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0384 0.0787
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0977 0.0931
Echinococcus granulosus dna polymerase eta 0.0019 0.0193 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1263 0.1177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0706 0.0659
Echinococcus multilocularis geminin 0.0168 0.3867 0.3835
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0193 0.0591
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.097 0.1661
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0118 0.0085
Brugia malayi RNA binding protein 0.0188 0.4358 0.6222
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0589 0.0541
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0248 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0206 0.0021
Brugia malayi nuclear receptor RXR 0.0019 0.0193 0.0275
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0706 0.0659
Mycobacterium tuberculosis Conserved protein 0.0035 0.0597 0.0934
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0548 0.1902
Echinococcus multilocularis dna polymerase eta 0.0019 0.0193 0.0143
Schistosoma mansoni hypothetical protein 0.0093 0.2035 0.1956
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0706 0.1008
Echinococcus granulosus pyruvate kinase 0.0017 0.0152 0.0102
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.097 0.1661
Loa Loa (eye worm) RNA binding protein 0.0188 0.4358 0.6201
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0548 0.0731
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0248 0.0151
Echinococcus multilocularis pyruvate kinase 0.0017 0.0152 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0647 0.0873
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0193 0.0402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0156 0.0058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.03
Brugia malayi CXXC zinc finger family protein 0.0029 0.0455 0.065
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.014 0.009
Loa Loa (eye worm) hypothetical protein 0.0093 0.2035 0.2865
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0455 0.0598
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.5247 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.039 0.0294
Brugia malayi phosphofructokinase 0.0111 0.2462 0.3516
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0384 0.1769
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2462 0.348
Brugia malayi nuclear receptor NHR-67 0.0019 0.0193 0.0275
Brugia malayi nuclear hormone receptor 0.0039 0.0706 0.1008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.162 1
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0193 0.0143
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0193 0.0402
Echinococcus multilocularis pyruvate kinase 0.0017 0.0152 0.0102
Schistosoma mansoni zinc finger protein 0.0021 0.0241 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0156 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Echinococcus multilocularis musashi 0.0027 0.039 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0706 0.0614
Brugia malayi 6-phosphofructokinase 0.0111 0.2462 0.3516
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0193 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0093 0.2035 0.1994
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0573 0.0767
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0977 0.1262
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0193 0.0221
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.162 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0597 0.1026
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0193 0.0096
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1156 0.6913
Brugia malayi ecdysteroid receptor 0.0039 0.0706 0.1008
Entamoeba histolytica hypothetical protein 0.007 0.1452 0.5548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0706 0.1008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0977 0.3717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0706 0.0958
Echinococcus multilocularis expressed protein 0.0034 0.0573 0.0525
Giardia lamblia Pyruvate kinase 0.0033 0.0548 0.4799
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0193 0.0096
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0193 0.0143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0706 0.0958
Mycobacterium ulcerans glutaminase 0.0271 0.6401 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0118 0.0068
Leishmania major DNA polymerase eta, putative 0.0019 0.0193 0.0402
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0282 0.0232
Loa Loa (eye worm) intermediate filament protein 0.0027 0.039 0.0504
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2462 0.3656
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0093 0.2035 0.1994
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0597 0.0934
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0706 0.0614
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0193 0.0402
Entamoeba histolytica hypothetical protein 0.007 0.1452 0.5548
Brugia malayi hypothetical protein 0.0019 0.0193 0.0275
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0706 0.0614
Brugia malayi hypothetical protein 0.0233 0.5481 0.7825
Brugia malayi MH2 domain containing protein 0.0119 0.2659 0.3796
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.03
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0955 0.557
Schistosoma mansoni ap endonuclease 0.0019 0.0206 0.0109
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0206 0.0172
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0471 0.2352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0706 0.1008
Loa Loa (eye worm) glutaminase 2 0.0271 0.6401 0.9133
Loa Loa (eye worm) hypothetical protein 0.0202 0.4704 0.6698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0118 0.0068
Echinococcus granulosus pyruvate kinase 0.0017 0.0152 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.039 0.0504
Trypanosoma brucei ISWI complex protein 0.0015 0.0098 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0597 0.2111
Onchocerca volvulus 0.0035 0.0597 0.1259
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.162 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0248 0.03
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0597 0.0934
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0548 0.0731
Schistosoma mansoni cpg binding protein 0.0029 0.0455 0.036
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0548 0.1105
Onchocerca volvulus 0.0035 0.0597 0.1259
Echinococcus granulosus geminin 0.0168 0.3867 0.3835
Loa Loa (eye worm) hypothetical protein 0.0027 0.039 0.0504
Schistosoma mansoni ap endonuclease 0.0019 0.0206 0.0109
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0471 0.1225
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0548 0.0571
Schistosoma mansoni hypothetical protein 0.0022 0.0282 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0471 0.0448
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0977 0.384
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0085 0.0122
Brugia malayi hypothetical protein 0.0019 0.0193 0.0275
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Schistosoma mansoni pyruvate kinase 0.0033 0.0548 0.0454
Loa Loa (eye worm) hypothetical protein 0.0149 0.3406 0.4835
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0706 0.1598
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0706 0.0659
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0118 0.0169
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2462 0.2424
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0706 0.1008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0193 0.0591
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0302 0.0478
Loa Loa (eye worm) hypothetical protein 0.0035 0.0597 0.0802
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0977 0.0931
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0955 0.3622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0706 0.0958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0221
Echinococcus granulosus lamin dm0 0.0027 0.039 0.0341
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0193 0.0275
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0548 0.0782
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0206 0.0021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.162 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0152 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0093 0.2035 0.2905
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0471 0.2352

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 32 nM Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex. ChEMBL. 9397175
Ki (binding) = 32 nM Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex. ChEMBL. 9397175
Ratio (binding) = 12.5 Ratio of binding affinity of CCK-A receptor of guinea pig pancreas membranes to the binding affinity of CCK-B receptor of guinea pig cortex. ChEMBL. 9397175

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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