Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0217 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.3645 | 0.3645 |
Echinococcus multilocularis | acetylcholinesterase | 0.0217 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0217 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0217 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0217 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0217 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0217 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0217 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 nM | Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN) | ChEMBL. | 8831761 |
IC50 (functional) | = 3 nM | Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN) | ChEMBL. | 8831761 |
IC50 (functional) | = 50 nM | Compound was tested for the inhibition of LTB4 production in human whole blood (HWB) | ChEMBL. | 8831761 |
IC50 (functional) | = 50 nM | Compound was tested for the inhibition of LTB4 production in human whole blood (HWB) | ChEMBL. | 8831761 |
IC50 (binding) | = 70 nM | Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase | ChEMBL. | 8831761 |
IC50 (binding) | = 70 nM | Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase | ChEMBL. | 8831761 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8831761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.