Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0423 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3541 | 0.6201 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1439 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.3541 | 0.4757 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0423 | 0.0569 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0423 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0198 | 0.0096 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.3541 | 0.4757 |
Onchocerca volvulus | 0.0047 | 0.062 | 1 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0131 | 0.3689 | 0.341 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0709 | 0.0794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3541 | 0.6201 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.3541 | 0.4665 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0198 | 0.0127 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0423 | 0.0404 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0198 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0131 | 0.3689 | 0.4819 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0423 | 0.0995 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0437 | 0.0014 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.3541 | 0.4614 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.7443 | 1 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1439 | 0.2383 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0423 | 0.0404 |
Onchocerca volvulus | 0.0042 | 0.0423 | 0.6823 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.1439 | 0.1793 |
Onchocerca volvulus | 0.0042 | 0.0423 | 0.6823 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0423 | 0.0311 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0311 | 0.0251 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0423 | 0.0995 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0437 | 0.0014 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1439 | 0.1713 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.647 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0423 | 0.0569 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0198 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0311 | 0.5013 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.3541 | 0.4665 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.042 | 0.0969 |
Echinococcus granulosus | geminin | 0.0183 | 0.5632 | 0.75 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0269 | 0.8783 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1439 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1439 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0128 | 0.0171 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.7577 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0423 | 0.0995 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.4138 | 0.3879 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.4733 | 0.5156 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0423 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0198 | 0.0127 |
Onchocerca volvulus | 0.0042 | 0.0423 | 0.6823 | |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0667 | 0.0746 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.3541 | 0.4757 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.062 | 0.0895 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.042 | 0.6774 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0423 | 0.0311 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0301 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.5632 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0423 | 0.0404 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.647 |
Brugia malayi | hypothetical protein | 0.0232 | 0.7443 | 1 |
Brugia malayi | RNA binding protein | 0.0126 | 0.3541 | 0.4665 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.5632 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.1439 | 0.1933 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.3541 | 0.4614 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0131 | 0.3689 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.7577 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0423 | 0.0537 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0423 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0423 | 0.0995 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.062 | 0.0895 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0709 | 0.0794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3541 | 0.6201 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1439 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0311 | 0.0418 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1439 | 0.1713 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0423 | 0.0995 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0423 | 0.0404 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0198 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.4138 | 0.3879 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.4138 | 0.3879 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3541 | 0.6201 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.042 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0709 | 0.0952 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.7577 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0131 | 0.3689 | 0.3907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3541 | 0.6201 |
Echinococcus multilocularis | geminin | 0.0183 | 0.5632 | 0.75 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0131 | 0.3689 | 0.4819 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0198 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.7443 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0437 | 0.0014 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.4733 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.062 | 0.0673 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0301 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0779 | 0.0371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0709 | 0.0952 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0423 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0423 | 0.0569 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0437 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.7443 | 1 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1439 | 0.2383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.