Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhi | Dihydrofolate reductase | Starlite/ChEMBL | References |
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Gallus gallus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 6.23 | Inhibitory activity against dihydrofolate reductase | ChEMBL. | 11495588 |
Activity (binding) | = 6.23 | Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 | ChEMBL. | 1507206 |
Activity (binding) | = 4.84 % | Binding affinity for dihydrofolate reductase from Lactobacillus casei | ChEMBL. | 9379435 |
Activity (binding) | = 4.84 % | Binding affinity for dihydrofolate reductase from Lactobacillus casei | ChEMBL. | 9379435 |
Ki (binding) | = 4.7 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 5.38 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 6.23 | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Ki (binding) | = 6.23 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Log (binding) | = 6.23 1/Ki | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Log 1/C (binding) | = 4.7 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver Dihydrofolate reductase. | ChEMBL. | 7277386 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver dihydrofolate reductase. | ChEMBL. | 6345782 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver dehydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/C (functional) | = 3.61 | Inhibitory activity against murine tumor cells (L5178Y/R) | ChEMBL. | 7086836 |
Log 1/C (binding) | = 4.7 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/C (functional) | = 5.27 | Inhibitory activity against murine tumor cells (L5178Y/S) | ChEMBL. | 7086836 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver dihydrofolate reductase. | ChEMBL. | 6345782 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver Dihydrofolate reductase. | ChEMBL. | 7277386 |
Log 1/C (binding) | = 5.33 | Inhibition of bovine liver dehydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/C (binding) | = 6.23 | Inhibition of dihydrofolate reductase (DHFR) from E. coli. | ChEMBL. | 3882967 |
Log 1/C (binding) | = 6.23 | In vitro inhibition of E. Coli dihydrofolate reductase. | ChEMBL. | 7005446 |
Log 1/Ki (binding) | = 4.7 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki (binding) | = 5.38 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki app (binding) | = 4.7 | Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 5.38 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 5.67 | Inhibition of dihydrofolate reductase from bovine liver | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 5.67 | Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 4.7 | Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 5.38 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 5.67 | Inhibition of dihydrofolate reductase from bovine liver | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 5.67 | Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 6.23 | Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli | ChEMBL. | 7017146 |
Log 1/Ki app (binding) | = 6.23 | Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase | ChEMBL. | 3276891 |
Log 1/Ki app (binding) | = 6.23 | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log Ki (binding) | = 6.23 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
log(1/I50) (binding) | = 5.33 | Inhibition of bovine liver dihydrofolate reductase using dihydrofolic acid as substrate | ChEMBL. | 458817 |
logD (ADMET) | = -0.8 | Partition coefficient (logD) (aqueous phase 0.1 N HCl) | ChEMBL. | 3701780 |
logD | = -0.8 | Compound was evaluated for the partition coefficients probably at the pH >> 7.2 at the aqueous phase 0.1 N HCl | ChEMBL. | 7005446 |
logD (ADMET) | = -0.8 | Partition coefficient (logD) (aqueous phase 0.1 N HCl) | ChEMBL. | 2502631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
16 literature references were collected for this gene.